1985
Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children.
Kovatch A, Wald E, Albo V, Prin W, Orlando S, Wollman M, Phebus C, Shapiro E. Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children. Pediatrics 1985, 76: 754-60. PMID: 3903647, DOI: 10.1542/peds.76.5.754.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Infective AgentsAntineoplastic AgentsBacterial InfectionsChildChild, PreschoolClinical Trials as TopicDouble-Blind MethodDrug CombinationsDrug Therapy, CombinationFemaleHumansInfantLeukemia, LymphoidLeukemia, Myeloid, AcuteMaleMicrobial Sensitivity TestsRandom AllocationSulfamethoxazoleTrimethoprimTrimethoprim, Sulfamethoxazole Drug CombinationConceptsTrimethoprim/sulfamethoxazoleOral trimethoprim/sulfamethoxazoleTrimethoprim/sulfamethoxazole groupFebrile episodesBacterial infectionsAcute leukemiaSolid tumorsPlacebo-controlled studyFrequency of bacteremiaInduction phaseInvasive fungal infectionsLife-table analysisGranulocytopenic childrenInduction chemotherapyReceiving placeboIntensive chemotherapyPlacebo groupOral thrushMean durationChemotherapyBacteremiaFungal infectionsOverall riskCancer chemotherapyInfection
1984
Resolving the Pneumococcal Vaccine Controversy: Are There Alternatives to Randomized Clinical Trials?
Clemens J, Shapiro E. Resolving the Pneumococcal Vaccine Controversy: Are There Alternatives to Randomized Clinical Trials? Clinical Infectious Diseases 1984, 6: 589-600. PMID: 6390636, DOI: 10.1093/clinids/6.5.589.Peer-Reviewed Original Research