Pneumococcal vaccines: history, current status, and future directions
Butler J, Shapiro E, Carlone G. Pneumococcal vaccines: history, current status, and future directions. The American Journal Of Medicine 1999, 107: 69-76. PMID: 10451012, DOI: 10.1016/s0002-9343(99)00105-9.Peer-Reviewed Original ResearchConceptsPneumococcal polysaccharide vaccinePolysaccharide vaccinePneumococcal infectionCertain underlying medical conditionsSerious pneumococcal diseaseCommunity-acquired pneumoniaPneumococcal conjugate vaccineUnderlying medical conditionsAnti-pneumococcal antibodiesLarger efficacy trialPrevention of infectionDrug-resistant strainsImmunocompetent childrenPneumococcal diseasePneumococcal vaccineBacterial meningitisConjugate vaccineCase fatalityDNA vaccineInvasive infectionsPneumococcal polysaccharideEfficacy trialsImmune responseMedical conditionsHigh risk