2021
Editorial: Regulatory T Cell Heterogeneity: Canonical and Non-Canonical Functions
Sefik E, Hori S, Vasanthakumar A. Editorial: Regulatory T Cell Heterogeneity: Canonical and Non-Canonical Functions. Frontiers In Immunology 2021, 12: 722563. PMID: 34630397, PMCID: PMC8492903, DOI: 10.3389/fimmu.2021.722563.Peer-Reviewed Original Research
2020
An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint
Ramanan D, Sefik E, Galván-Peña S, Wu M, Yang L, Yang Z, Kostic A, Golovkina T, Kasper D, Mathis D, Benoist C. An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint. Cell 2020, 181: 1276-1290.e13. PMID: 32402238, PMCID: PMC7393667, DOI: 10.1016/j.cell.2020.04.030.Peer-Reviewed Original ResearchConceptsDouble-negative feedback loopTreg proportionImmunological modeGut immune responseGut commensalsControlling gut inflammationSpecies levelInbred mouse strainsMulti-generational transmissionTreg-dependent mannerCellular perturbationsRegulatory T cellsDisease susceptibilityNon-epigeneticMaternal transmissionInflammatory disease susceptibilityNon-geneticGut inflammationT cellsGenetic tuningMouse strainsImmune responseMultiple generationsImmune systemFeedback loop