2020
An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint
Ramanan D, Sefik E, Galván-Peña S, Wu M, Yang L, Yang Z, Kostic A, Golovkina T, Kasper D, Mathis D, Benoist C. An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint. Cell 2020, 181: 1276-1290.e13. PMID: 32402238, PMCID: PMC7393667, DOI: 10.1016/j.cell.2020.04.030.Peer-Reviewed Original ResearchConceptsDouble-negative feedback loopTreg proportionImmunological modeGut immune responseGut commensalsControlling gut inflammationSpecies levelInbred mouse strainsMulti-generational transmissionTreg-dependent mannerCellular perturbationsRegulatory T cellsDisease susceptibilityNon-epigeneticMaternal transmissionInflammatory disease susceptibilityNon-geneticGut inflammationT cellsGenetic tuningMouse strainsImmune responseMultiple generationsImmune systemFeedback loop
2014
Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut
Morton A, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D. Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 6696-6701. PMID: 24753589, PMCID: PMC4020091, DOI: 10.1073/pnas.1405634111.Peer-Reviewed Original ResearchConceptsIntestinal microbiotaKaede transgenic miceFluorescent reportersIntestinal leukocytesFilamentous bacteriaGutMyeloid populationsK/BxN miceTh17 cellsEndoscopic approachImmune cellsLeukocyte subsetsAutoinflammatory diseasesImmune homeostasisDescending colonTransgenic miceLeukocyte movementLeukocytesMounting evidenceCellsMiceMicrobiotaTraffickingBacteria