2023
Regulatory T cells in the face of the intestinal microbiota
Ramanan D, Pratama A, Zhu Y, Venezia O, Sassone-Corsi M, Chowdhary K, Galván-Peña S, Sefik E, Brown C, Gélineau A, Mathis D, Benoist C. Regulatory T cells in the face of the intestinal microbiota. Nature Reviews Immunology 2023, 23: 749-762. PMID: 37316560, DOI: 10.1038/s41577-023-00890-w.Peer-Reviewed Original ResearchMeSH KeywordsAntigensForkhead Transcription FactorsGastrointestinal MicrobiomeHumansIntestinesReceptors, Antigen, T-CellT-Lymphocytes, Regulatory
2022
EBVerified TCRs and multiple sclerosis.
Sefik E, O'Connor KC. EBVerified TCRs and multiple sclerosis. Science Immunology 2022, 7: eadf0763. PMID: 36206354, DOI: 10.1126/sciimmunol.adf0763.Peer-Reviewed Original Research
2013
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn D, Kuswanto W, Kolodin D, Shadrach J, Cerletti M, Jang Y, Sefik E, Tan T, Wagers A, Benoist C, Mathis D. A Special Population of Regulatory T Cells Potentiates Muscle Repair. Cell 2013, 155: 1282-1295. PMID: 24315098, PMCID: PMC3894749, DOI: 10.1016/j.cell.2013.10.054.Peer-Reviewed Original ResearchConceptsTreg cellsMuscle repairDepletion of Treg cellsPopulation of Treg cellsSuppressors of immune responsesMuscle repair in vivoMyeloid lineage cellsGrowth factor amphiregulinSatellite cells in vitroImpaired muscle repairCells in vitroGenetically dystrophic miceProinflammatory infiltratesSkeletal muscle of miceMuscle of miceTreg activityTreg populationDystrophic miceImmune responseMuscular dystrophyTherapeutic opportunitiesNonimmunologic processesTregsWound repairMuscle damage