2023
1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. 1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma. 2023, a1133-a1133. DOI: 10.1136/jitc-2023-sitc2023.1025.Peer-Reviewed Original Research
2020
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses
Low JS, Farsakoglu Y, Vesely M, Sefik E, Kelly JB, Harman CCD, Jackson R, Shyer JA, Jiang X, Cauley LS, Flavell RA, Kaech SM. Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. Journal Of Experimental Medicine 2020, 217: e20192291. PMID: 32525985, PMCID: PMC7398161, DOI: 10.1084/jem.20192291.Peer-Reviewed Original ResearchConceptsMemory T cellsT cellsLung CD8TRM cellsTissue-resident memory T cellsLong-term protective immunityT cell reactivationCell reactivationPortal of infectionCell functional responsesMemory CD8Protective immunityEffector responsesLymphoid organsCD8Distinct functional responsesFunctional responseReactivationCellsAPCActivation kineticsCritical roleResponseInfectionImmunity
2019
Indiscriminate nature of lung resident CD8+ TRM cells reactivation and their varied reactivation profiles
LOW J, Amezcua C, Sefik E, Harman C, Jackson R, Jiang X, Kelly J, Cauley L, Flavell R, Kaech S. Indiscriminate nature of lung resident CD8+ TRM cells reactivation and their varied reactivation profiles. The Journal Of Immunology 2019, 202: 129.9-129.9. DOI: 10.4049/jimmunol.202.supp.129.9.Peer-Reviewed Original ResearchAntigen-presenting cellsTRM cellsCell reactivationTissue-resident memory cellsLong-term protective immunityLung-resident CD8Resident memory cellsKinetics of CD8Portal of infectionAbstract CD8Memory CD8Bystander activationInfluenza infectionProtective immunityResident CD8Heterologous immunityCD8T cellsPeripheral tissuesAnatomical locationReactivation profileInfectionReactivation kineticsImmediate protectionImmunity