1995
Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis
Dunne M, al-Ramadi BK, Barthold SW, Flavell RA, Fikrig E. Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis. Infection And Immunity 1995, 63: 1611-1614. PMID: 7890431, PMCID: PMC173199, DOI: 10.1128/iai.63.4.1611-1614.1995.Peer-Reviewed Original ResearchConceptsAnti-OspA antibodyMurine Lyme borreliosisDevelopment of antibodiesMajor outer surface proteinsSalmonella typhimurium strainsOral vaccinationIntradermal challengeMouse modelAttenuated strainOuter surface proteinsHigh titersLyme borreliosisLyme diseaseBorrelia burgdorferiTyphimurium strainsCausative agentDiseaseAntibodiesSurface proteinsSalmonella typhimuriumGavageVaccinationMiceTitersBorreliosis
1993
Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice.
Bockenstedt LK, Fikrig E, Barthold SW, Kantor FS, Flavell RA. Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice. The Journal Of Immunology 1993, 151: 900-6. PMID: 8335917, DOI: 10.4049/jimmunol.151.2.900.Peer-Reviewed Original ResearchConceptsA antibodiesOsp AProtective immunityMurine immune responseBorrelia burgdorferiElicit protective immunityGroups of miceDevelopment of antibodiesOuter surface protein A.Vaccine AgsChallenge infectionPassive immunizationActive immunizationImmune responseEtiologic agentIndirect immunofluorescenceLyme diseaseMiceVaccinationA antiseraAntibodiesImmunityConformational epitopesA proteinImmunization