2018
Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism
Heipertz EL, Harper J, Lopez CA, Fikrig E, Hughes ME, Walker WE. Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism. The Journal Of Immunology 2018, 201: ji1701677. PMID: 29760192, PMCID: PMC9351006, DOI: 10.4049/jimmunol.1701677.Peer-Reviewed Original ResearchConceptsImmune cellsZT 19C57BL/6 miceWorse outcomesTLR2 agonist lipoteichoic acidCircadian rhythmTLR2 knockout miceFemale C57BL/6 miceMale C57BL/6 miceSeverity of sepsisBone marrow chimerasTLR2-dependent mechanismIL-6 productionTLR2-DependentSepsis severityCecal ligationSepsis phenotypesSepsisC57BL/6 cellsSimilar outcomesMiceMouse cecumLipoteichoic acidMurine macrophagesCLPDaily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells
Silver AC, Buckley SM, Hughes ME, Hastings AK, Nitabach MN, Fikrig E. Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells. Heliyon 2018, 4: e00579. PMID: 29862343, PMCID: PMC5968137, DOI: 10.1016/j.heliyon.2018.e00579.Peer-Reviewed Original ResearchAdherent splenocytesToll-like receptor expressionMRNA levelsProtein levelsSplenic immune cellsToll-like receptorsDependent immune responsesZeitgeber time (ZT) 1Adherent cell populationDendritic cellsTLR3 ligandTLR ligandsCytokine expressionSplenocyte populationImmune cellsReceptor expressionImmune responseSplenic macrophagesB cellsRhythmic expressionCell populationsTLRSplenocytesDaily light-dark cycleCircadian rhythm
2012
The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity
Silver AC, Arjona A, Walker WE, Fikrig E. The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity. Immunity 2012, 36: 251-261. PMID: 22342842, PMCID: PMC3315694, DOI: 10.1016/j.immuni.2011.12.017.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Receptor 9Adaptive immune responsesInnate immune systemCircadian molecular clockSepsis inductionTLR9 expressionTLR9 ligandsImmune responseVaccination modelAdaptive immunityMouse modelImmune systemDisease severityHomeostatic processesCircadian rhythmBiologic processesDirect molecular linkMolecular linkRhythmSepsisImmunotherapyImmunoprophylaxisExpressionInnate
2011
Circadian rhythms influence disease severity in a mouse model of sepsis (110.9)
Walker W, Bozzi A, Fikrig E. Circadian rhythms influence disease severity in a mouse model of sepsis (110.9). The Journal Of Immunology 2011, 186: 110.9-110.9. DOI: 10.4049/jimmunol.186.supp.110.9.Peer-Reviewed Original ResearchInflammatory responseMouse modelCircadian rhythmSerum proinflammatory cytokinesPuncture (CLP) mouse modelRisk of mortalitySeptic patientsSepsis inductionCecal ligationSepsis phenotypesEarly mortalityProinflammatory cytokinesSevere hypothermiaDisease scoreCLP modelDisease severitySepsisCreatine kinaseMortalityPatientsMiceRhythmSeverityTime 19Mammalian physiology