2023
Long-term opioid therapy trajectories and overdose in patients with and without cancer.
Merlin J, Black A, Midboe A, Troszak L, Asch S, Bohnert A, Fenton B, Giannitrapani K, Glassman P, Kerns R, Silveira M, Lorenz K, Abel E, Becker W. Long-term opioid therapy trajectories and overdose in patients with and without cancer. BMJ Oncology 2023, 2: e000023. PMID: 38259328, PMCID: PMC10802123, DOI: 10.1136/bmjonc-2022-000023.Peer-Reviewed Original ResearchLong-term opioid therapyVeterans Health Administration databaseRetrospective cohort studyCornerstone of managementOpioid overdose riskHealth Administration databaseOpioid-related overdosesPresence of cancerRole of cancerOpioid receiptOpioid therapyCohort studyConclusions PatientsMost patientsObjective painOpioid risksDose/Opioid overdoseOverdose riskInternational ClassificationLower riskPatientsEffect of trajectoriesCancerAdministration database
2020
Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones
Simonov M, Abel EA, Skanderson M, Masoud A, Hauser RG, Brandt CA, Wilson FP, Laine L. Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones. Clinical Gastroenterology And Hepatology 2020, 19: 72-79.e21. PMID: 32147588, PMCID: PMC7483196, DOI: 10.1016/j.cgh.2020.02.053.Peer-Reviewed Original ResearchConceptsProton pump inhibitorsPPI useKidney stonesCohort studyLevothyroxine useTime-varying Cox proportional hazardsHistamine-2 receptor antagonistsPropensity score-matched subsetIncident kidney stonesUrinary ion concentrationsLarge cohort studyCox proportional hazardsPropensity matching analysisDose-dependent increaseNegative control exposureH2RA usePPI usersMost patientsPPI usageAcid suppressionAdjusted analysisMedication usageRetrospective studyPump inhibitorsUnadjusted analyses