2019
Local–regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial)
Bellon JR, Guo H, Barry WT, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis M, Wolff AC, Carey LA, Overmoyer BA, Partridge AH, Hudis CA, Krop I, Burstein HJ, Winer EP, Tolaney SM. Local–regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial). Breast Cancer Research And Treatment 2019, 176: 303-310. PMID: 31004299, DOI: 10.1007/s10549-019-05238-4.Peer-Reviewed Original ResearchConceptsHER2-positive breast cancerLocal-regional recurrenceDisease-free survivalEffective anti-HER2 therapyLRR-free survivalAnti-HER2 therapyBreast-conserving surgeryBreast cancerRadiation therapySystemic therapyHormone receptor-positive tumorsProspective multi-institutional studyHER2-negative diseaseHER2-positive diseaseNegative axillary nodesEffective systemic therapyProspective multicenter trialEarly-stage patientsKaplan-Meier methodReceptor-positive tumorsHER2-positive tumorsMulti-institutional studyFuture investigational effortsAdjuvant trastuzumabProtocol therapy
2008
Tangential Radiotherapy Without Axillary Surgery in Early-Stage Breast Cancer: Results of a Prospective Trial
Wong JS, Taghian AG, Bellon JR, Keshaviah A, Smith BL, Winer EP, Silver B, Harris JR. Tangential Radiotherapy Without Axillary Surgery in Early-Stage Breast Cancer: Results of a Prospective Trial. International Journal Of Radiation Oncology • Biology • Physics 2008, 72: 866-870. PMID: 18394815, DOI: 10.1016/j.ijrobp.2008.01.031.Peer-Reviewed Original ResearchConceptsNegative axillary nodesAxillary surgeryHormonal therapyBreast cancerAxillary nodesBreast radiotherapyLow regional recurrence ratesMedian pathologic tumor sizeHormone-responsive breast cancerMulti-institutional prospective studyEarly-stage breast cancerIpsilateral breast recurrencePathologic tumor sizeRegional nodal failureBreast-conserving surgeryInvasive breast cancerRegional nodal recurrenceWhole breast radiotherapyPositive breast cancerRegional recurrence rateLymphatic vessel invasionYears of ageAxillary treatmentBreast recurrenceMetastatic disease
2005
American Society of Clinical Oncology Guideline Recommendations for Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer
Lyman GH, Giuliano AE, Somerfield MR, Benson AB, Bodurka DC, Burstein HJ, Cochran AJ, Cody HS, Edge SB, Galper S, Hayman JA, Kim TY, Perkins CL, Podoloff DA, Sivasubramaniam VH, Turner RR, Wahl R, Weaver DL, Wolff AC, Winer EP. American Society of Clinical Oncology Guideline Recommendations for Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer. Journal Of Clinical Oncology 2005, 23: 7703-7720. PMID: 16157938, DOI: 10.1200/jco.2005.08.001.Peer-Reviewed Original ResearchConceptsAxillary lymph node dissectionEarly-stage breast cancerSentinel node biopsyCompletion axillary lymph node dissectionBreast cancerNode biopsyUse of SNBSentinel lymph node biopsyNegative axillary nodesLymph node dissectionAxillary lymph nodesLymph node biopsyStage breast cancerHealth Services CommitteeLong-term survivalAmerican SocietyUnknown clinical significanceIsolated cancer cellsAxillary metastasesNode dissectionSLN biopsyAxillary nodesSentinel lymphSLN evaluationLymph nodes