2022
The Phase II MutHER Study of Neratinib Alone and in Combination with Fulvestrant in HER2-Mutated, Non-amplified Metastatic Breast CancerNeratinib and Fulvestrant in HER2-Mutated Breast Cancer
X. C, Luo J, Freedman RA, Pluard TJ, Nangia JR, Lu J, Valdez-Albini F, Cobleigh M, Jones JM, Lin NU, Winer EP, Marcom PK, Thomas S, Anderson J, Haas B, Bucheit L, Bryce R, Lalani AS, Carey LA, Goetz MP, Gao F, Kimmick G, Pegram MD, Ellis MJ, Bose R. The Phase II MutHER Study of Neratinib Alone and in Combination with Fulvestrant in HER2-Mutated, Non-amplified Metastatic Breast CancerNeratinib and Fulvestrant in HER2-Mutated Breast Cancer. Clinical Cancer Research 2022, 28: 1258-1267. PMID: 35046057, DOI: 10.1158/1078-0432.ccr-21-3418.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerBreast cancerER cohortEstrogen receptor-positive breast cancerReceptor-positive breast cancerClinical benefit rateDual HER2 blockadePhase II trialEfficacy of neratinibHER2 blockadeNeratinib monotherapyStable diseaseII trialHER2 mutationsLobular histologyPartial responseEndocrine resistanceBenefit ratePatientsFurther evaluationCancerFulvestrantHER2NeratinibProgression
2008
Perceptions and Management Approaches of Physicians Who Care for Women with Ductal Carcinoma In Situ
Partridge A, Winer JP, Golshan M, Bellon JR, Blood E, Dees EC, Sampson E, Emmons KM, Winer E. Perceptions and Management Approaches of Physicians Who Care for Women with Ductal Carcinoma In Situ. Clinical Breast Cancer 2008, 8: 275-280. PMID: 18650159, DOI: 10.3816/cbc.2008.n.032.Peer-Reviewed Original ResearchConceptsDuctal carcinomaBreast cancerOverall healthPatient's overall healthLongitudinal cohort studyCohort studyMedian ageMedical oncologistsEligible physiciansPatient outcomesMultivariable modelPhysicians' perceptionsDCISNew patientsPatientsResponse rateFurther evaluationTheoretical patientsPhysiciansWomenMore womenCarcinomaCancerRisky diseaseRisk