2014
Use and duration of chemotherapy in patients with metastatic breast cancer according to tumor subtype and line of therapy.
Seah DS, Luis IV, Macrae E, Sohl J, Litsas G, Winer EP, Lin NU, Burstein HJ. Use and duration of chemotherapy in patients with metastatic breast cancer according to tumor subtype and line of therapy. Journal Of The National Comprehensive Cancer Network 2014, 12: 71-80. PMID: 24453294, DOI: 10.6004/jnccn.2014.0008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansMiddle AgedNeoplasm MetastasisNeoplasm StagingReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneTriple Negative Breast NeoplasmsConceptsMetastatic breast cancerDuration of chemotherapyLines of therapyBreast cancerTumor subtypesDana-Farber Cancer InstituteSixth-line therapyMedian overall survivalBenefit of chemotherapyResult of progressionWarrants further studyChemotherapy linesChemotherapy regimenProlonged therapyMBC diagnosisMedian durationOverall survivalClinicopathologic characteristicsConsecutive patientsMedian ageClinical benefitMedical recordsChemotherapyCancer InstitutePatients
2005
Adjuvant Chemotherapy in Older and Younger Women With Lymph Node–Positive Breast Cancer
Muss HB, Woolf S, Berry D, Cirrincione C, Weiss RB, Budman D, Wood WC, Henderson IC, Hudis C, Winer E, Cohen H, Wheeler J, Norton L, B F. Adjuvant Chemotherapy in Older and Younger Women With Lymph Node–Positive Breast Cancer. JAMA 2005, 293: 1073-1081. PMID: 15741529, DOI: 10.1001/jama.293.9.1073.Peer-Reviewed Original ResearchConceptsLymph node-positive breast cancerNode-positive breast cancerTreatment-related mortalityDisease-free survivalAdjuvant chemotherapyBreast cancerOverall survivalOlder womenMore chemotherapyOlder patientsHigh treatment-related mortalityAge groupsYoung womenPositive lymph nodesHealthy older patientsDuration of chemotherapyGood general healthSmaller tumor sizeBreast cancer mortalityBreast cancer patientsCommunity medical centerDifferent age groupsTamoxifen useLymph nodesRetrospective review