2020
Phase II Single-Arm Study of Preoperative Letrozole for Estrogen Receptor-Positive Postmenopausal Ductal Carcinoma In Situ: CALGB 40903 (Alliance).
Hwang ES, Hyslop T, Hendrix LH, Duong S, Bedrosian I, Price E, Caudle A, Hieken T, Guenther J, Hudis CA, Winer E, Lyss AP, Dickson-Witmer D, Hoefer R, Ollila DW, Hardman T, Marks J, Chen YY, Krings G, Esserman L, Hylton N. Phase II Single-Arm Study of Preoperative Letrozole for Estrogen Receptor-Positive Postmenopausal Ductal Carcinoma In Situ: CALGB 40903 (Alliance). Journal Of Clinical Oncology 2020, 38: 1284-1292. PMID: 32125937, PMCID: PMC7164489, DOI: 10.1200/jco.19.00510.Peer-Reviewed Original ResearchConceptsER-positive DCISMagnetic resonance imagingPreoperative letrozoleEndocrine therapyDuctal carcinomaInvasive cancerH-scorePhase II single-arm studyExtended endocrine therapyMonths of letrozolePrimary endocrine therapyPrimary nonoperative treatmentPrimary end pointBreast magnetic resonance imagingCooperative group trialsSingle-arm studyER H-scoreShort-term coursePositive DCISNonoperative treatmentPostmenopausal patientsPostmenopausal womenFuture trialsStudy protocolBiomarker changes
2016
Time trends in incidence rates and survival of newly diagnosed stage IV breast cancer by tumor histology: a population-based analysis
Di Meglio A, Freedman RA, Lin NU, Barry WT, Metzger-Filho O, Keating NL, King TA, Sertoli MR, Boccardo F, Winer EP, Vaz-Luis I. Time trends in incidence rates and survival of newly diagnosed stage IV breast cancer by tumor histology: a population-based analysis. Breast Cancer Research And Treatment 2016, 157: 587-596. PMID: 27271765, DOI: 10.1007/s10549-016-3845-5.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerMedian overall survivalOverall survivalPopulation-based analysisDuctal carcinomaLobular carcinomaAnnual percent changeBreast cancerIncidence rateDe novo metastatic breast cancerEnd Results 9 registriesHormone receptor-positive tumorsNovo metastatic breast cancerMultivariable Cox regression modelsStage IV breast cancerAnnual age-adjusted incidence ratesAge-adjusted incidence ratesAdjusted hazard ratioBetter overall survivalDate of diagnosisReceptor-positive tumorsBreast cancer incidenceCox regression modelHazard ratioTumor histology
2015
Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial
Metzger Filho O, Giobbie-Hurder A, Mallon E, Gusterson B, Viale G, Winer EP, Thürlimann B, Gelber RD, Colleoni M, Ejlertsen B, Debled M, Price KN, Regan MM, Coates AS, Goldhirsch A. Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial. Journal Of Clinical Oncology 2015, 33: 2772-2779. PMID: 26215945, PMCID: PMC4550691, DOI: 10.1200/jco.2015.60.8133.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic Agents, HormonalAntineoplastic Combined Chemotherapy ProtocolsAromatase InhibitorsBiomarkers, TumorBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansKi-67 AntigenLetrozoleMiddle AgedNitrilesReceptor, ErbB-2TamoxifenTreatment OutcomeTriazolesConceptsInvasive ductal carcinomaInvasive lobular carcinomaDisease-free survivalLobular carcinomaDFS eventsDuctal carcinomaLA subtypeBreast International Group (BIG) 1Early-stage invasive ductal carcinomaClassic invasive lobular carcinomaHER2-negative invasive ductal carcinomaKi-67 labeling indexLow proliferative activityMagnitude of benefitAdjuvant letrozoleMedian followBIG 1ILC subsetsMultivariable modelCox modelGroup 1LetrozoleCarcinomaLabeling indexPatients
2013
Long‐Term Risk Perceptions of Women With Ductal Carcinoma In Situ
Ruddy KJ, Meyer ME, Giobbie‐Hurder A, Emmons KM, Weeks JC, Winer EP, Partridge AH. Long‐Term Risk Perceptions of Women With Ductal Carcinoma In Situ. The Oncologist 2013, 18: 362-368. PMID: 23568001, PMCID: PMC3639521, DOI: 10.1634/theoncologist.2012-0376.Peer-Reviewed Original ResearchConceptsInvasive breast cancerBreast cancerDuctal carcinomaLifetime riskFuture breast cancer eventsHistory of DCISBreast cancer eventsTime of diagnosisLong-term followLongitudinal cohort studyFuture breast cancerWorse financial statusCohort studyMedian timeCancer eventsDCISOnly predictorModerate riskMultivariate modelCancerWomenDiagnosisRisk perceptionCarcinomaRecurrencePsychosexual Functioning and Body Image Following a Diagnosis of Ductal Carcinoma In Situ
Bober SL, Giobbie‐Hurder A, Emmons KM, Winer E, Partridge A. Psychosexual Functioning and Body Image Following a Diagnosis of Ductal Carcinoma In Situ. The Journal Of Sexual Medicine 2013, 10: 370-377. PMID: 22812628, DOI: 10.1111/j.1743-6109.2012.02852.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Agents, HormonalArousalBody ImageBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCohort StudiesCombined Modality TherapyDepressive DisorderFemaleFollow-Up StudiesHumansMassachusettsMastectomyMiddle AgedPersonal SatisfactionSexual BehaviorSurveys and QuestionnairesConceptsDiagnosis of DCISSexual functionHormonal therapyDuctal carcinomaPsychosexual functioningSexual functioningLarge-scale prospective studiesBody imageInvasive breast cancerProspective studyTreatment modalitiesTreatment optionsProspective surveySitu cancerBreast cancerDCISGeneral populationPsychosexual functionPatientsPsychosocial challengesDiagnosisTime pointsWomenMastectomySexual satisfaction
2010
The role of socioeconomic status in adjustment after ductal carcinoma in situ
de Moor JS, Partridge AH, Winer EP, Ligibel J, Emmons KM. The role of socioeconomic status in adjustment after ductal carcinoma in situ. Cancer 2010, 116: 1218-1225. PMID: 20143325, PMCID: PMC3072709, DOI: 10.1002/cncr.24832.Peer-Reviewed Original ResearchConceptsLow socioeconomic statusSocioeconomic statusDuctal carcinomaSocial supportTime of enrollmentImpact of SESDCIS diagnosisClinical characteristicsLow financial statusClinical depressionPhysical healthStudy periodFinancial statusWomenDepressionLow SESCarcinomaDistressAnxietyDiagnosisHigher financial statusStatusCurrent studyAssociation
2009
Physical Activity Behaviors in Women with Newly Diagnosed Ductal Carcinoma-In-Situ
Ligibel JA, Partridge A, Giobbie-Hurder A, Golshan M, Emmons K, Winer EP. Physical Activity Behaviors in Women with Newly Diagnosed Ductal Carcinoma-In-Situ. Annals Of Surgical Oncology 2009, 16: 106-112. PMID: 18953612, PMCID: PMC5842912, DOI: 10.1245/s10434-008-0174-x.Peer-Reviewed Original ResearchConceptsPhysical activityDuctal carcinomaTreatment-related variablesLongitudinal cohort studyStrenuous physical activityBreast cancer riskLogistic regression modelingPhysical activity behaviorType of exerciseTamoxifen useCohort studyBilateral mastectomyEpidemiological evidenceSitu cancerReconstructive surgeryCancer riskDepressive symptomsExercise levelsMost womenExercise frequencyHealth outcomesActivity behaviorWomenExercise behaviorNonsignificant variables
2008
Perceptions and Management Approaches of Physicians Who Care for Women with Ductal Carcinoma In Situ
Partridge A, Winer JP, Golshan M, Bellon JR, Blood E, Dees EC, Sampson E, Emmons KM, Winer E. Perceptions and Management Approaches of Physicians Who Care for Women with Ductal Carcinoma In Situ. Clinical Breast Cancer 2008, 8: 275-280. PMID: 18650159, DOI: 10.3816/cbc.2008.n.032.Peer-Reviewed Original ResearchConceptsDuctal carcinomaBreast cancerOverall healthPatient's overall healthLongitudinal cohort studyCohort studyMedian ageMedical oncologistsEligible physiciansPatient outcomesMultivariable modelPhysicians' perceptionsDCISNew patientsPatientsResponse rateFurther evaluationTheoretical patientsPhysiciansWomenMore womenCarcinomaCancerRisky diseaseRiskRisk Perceptions and Psychosocial Outcomes of Women With Ductal Carcinoma In Situ: Longitudinal Results From a Cohort Study
Partridge A, Adloff K, Blood E, Dees EC, Kaelin C, Golshan M, Ligibel J, de Moor JS, Weeks J, Emmons K, Winer E. Risk Perceptions and Psychosocial Outcomes of Women With Ductal Carcinoma In Situ: Longitudinal Results From a Cohort Study. Journal Of The National Cancer Institute 2008, 100: 243-251. PMID: 18270338, DOI: 10.1093/jnci/djn010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnxietyBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCohort StudiesDepressionFemaleHumansLogistic ModelsLongitudinal StudiesMammographyMass ScreeningMassachusettsMiddle AgedNeoplasm Recurrence, LocalOdds RatioPredictive Value of TestsPrognosisQuality of LifeRisk AssessmentRisk FactorsConceptsLocal recurrence rateRecurrence ratePsychosocial outcomesDuctal carcinomaModerate riskCancer-related risksFavorable overall prognosisSystemic recurrence ratesBreast-conserving treatmentBreast cancer riskDCIS diagnosisCohort studyDCIS recurrenceOverall prognosisDisease recurrenceInvasive cancerDCISCancer riskPsychosocial concernsHealth behaviorsEnrollment surveySubstantial anxietyWomenInaccurate perceptionsModerate likelihood
2007
Follow-up care of patients with breast cancer
Tolaney SM, Winer EP. Follow-up care of patients with breast cancer. The Breast 2007, 16: 45-50. PMID: 17697780, DOI: 10.1016/j.breast.2007.07.005.Peer-Reviewed Original ResearchConceptsBreast cancerEarly detectionNew primary cancerInvasive breast cancerBreast cancer survivorsLong-term complicationsRoutine imaging studiesCare of patientsLocoregional recurrenceDistant metastasisPrimary cancerCancer survivorsDuctal carcinomaNew casesSurveillance strategiesImaging studiesCancerFurther studiesRecurrenceCareWomenComplicationsPatientsCarcinomaMetastasis
2005
Standards for follow-up care of patients with breast cancer
Peppercorn J, Partridge A, Burstein HJ, Winer EP. Standards for follow-up care of patients with breast cancer. The Breast 2005, 14: 500-508. PMID: 16288876, DOI: 10.1016/j.breast.2005.09.001.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsCancer survivorsBreast cancerEarly identificationNew primary cancerInvasive breast cancerCare of patientsCost-effective followLocoregional recurrenceLate complicationsDistant metastasisPrimary cancerRandomized trialsDuctal carcinomaComprehensive carePET scansSuch carePsychosocial problemsCareCancerSurvivorsRecurrenceFollowMore yearsBreast diagnosisOffering participants results of a clinical trial: sharing results of a negative study
Partridge AH, Wong JS, Knudsen K, Gelman R, Sampson E, Gadd M, Bishop KL, Harris JR, Winer EP. Offering participants results of a clinical trial: sharing results of a negative study. The Lancet 2005, 365: 963-964. PMID: 15766998, DOI: 10.1016/s0140-6736(05)71085-0.Peer-Reviewed Original ResearchConceptsClinical trialsNegative studiesPhase II trialClinical trial resultsClinical trial participantsII trialLocal recurrenceDuctal carcinomaBreast excisionTrial participantsResults of trialsTrial resultsTrialsMost participantsHigh ratePreliminary findingsWomenParticipantsPatientsCarcinomaRecurrenceExcisionEarly high rate
2001
Knowledge, Satisfaction, and Perceived Cancer Risk among Women Diagnosed with Ductal Carcinoma In Situ
Bluman L, Borstelmann N, Rimer B, Iglehart J, Winer E. Knowledge, Satisfaction, and Perceived Cancer Risk among Women Diagnosed with Ductal Carcinoma In Situ. Journal Of Women's Health 2001, 10: 589-598. PMID: 11559456, DOI: 10.1089/15246090152543175.Peer-Reviewed Original ResearchConceptsDuctal carcinomaBreast cancerInvasive breast cancerSelf-administered questionnaireDCIS diagnosisTumor RegistryDCISCancer riskFuture healthKnowledge deficitsPsychological distressWomenCarcinomaCancerRisk perceptionCareFuture studiesFuture investigationsAreas of concernPrognosisRecurrenceWidespread useMetastasisRegistryPrevalence