2020
Prevention of cardiovascular disease for historically marginalized racial and ethnic groups living with HIV: A narrative review of the literature
Muiruri C, Longenecker CT, Meissner EG, Okeke NL, Pettit AC, Thomas K, Velazquez E, Bloomfield GS. Prevention of cardiovascular disease for historically marginalized racial and ethnic groups living with HIV: A narrative review of the literature. Progress In Cardiovascular Diseases 2020, 63: 142-148. PMID: 32057785, PMCID: PMC7237291, DOI: 10.1016/j.pcad.2020.02.006.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCardiovascular DiseasesComorbidityHealth Status DisparitiesHealthcare DisparitiesHIV InfectionsHIV Long-Term SurvivorsHumansPreventive Health ServicesPrognosisProtective FactorsRace FactorsRisk AssessmentRisk FactorsSocial Determinants of HealthSocial MarginalizationSocioeconomic FactorsViral LoadVulnerable PopulationsConceptsHuman immunodeficiency virusCardiovascular diseaseComorbid human immunodeficiency virusNarrative reviewSocial determinantsRacial disparitiesCommon social determinantsEthnic disparities persistEthnic groupsCVD morbidityImmunodeficiency virusClinical practiceTranslation of researchClinical researchDisparities persistDiseaseHealthDisparitiesGroupMorbidityReviewPersonsPrevention
2019
Community Health Workers Improve Linkage to Hypertension Care in Western Kenya
Vedanthan R, Kamano JH, DeLong AK, Naanyu V, Binanay CA, Bloomfield GS, Chrysanthopoulou SA, Finkelstein EA, Hogan JW, Horowitz CR, Inui TS, Menya D, Orango V, Velazquez EJ, Were MC, Kimaiyo S, Fuster V. Community Health Workers Improve Linkage to Hypertension Care in Western Kenya. Journal Of The American College Of Cardiology 2019, 74: 1897-1906. PMID: 31487546, PMCID: PMC6788970, DOI: 10.1016/j.jacc.2019.08.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntihypertensive AgentsBlood PressureBlood Pressure DeterminationCluster AnalysisCommunicationCommunity Health ServicesCommunity Health WorkersFemaleHealth BehaviorHealth PromotionHealth Services AccessibilityHealth Services ResearchHumansHypertensionKenyaMaleMedication AdherenceMiddle AgedRisk FactorsSmartphoneSystoleTelemedicineConceptsCommunity health workersElevated blood pressureBlood pressureSystolic BPUsual careHealth workersHypertension careCovariate-adjusted mixed effects modelAverage overall followBaseline systolic BPHypertension care programCo-primary outcomesSystolic blood pressureSBP reductionHypertension controlOverall followSBP changeRisk factorsCare programLinkage of individualsCareMixed effects modelsGreater reductionMobile healthMortality
2018
Society of Thoracic Surgeons Risk Score and EuroSCORE-2 Appropriately Assess 30-Day Postoperative Mortality in the STICH Trial and a Contemporary Cohort of Patients With Left Ventricular Dysfunction Undergoing Surgical Revascularization
Bouabdallaoui N, Stevens SR, Doenst T, Petrie MC, Al-Attar N, Ali IS, Ambrosy AP, Barton AK, Cartier R, Cherniavsky A, Demondion P, Desvigne-Nickens P, Favaloro RR, Gradinac S, Heinisch P, Jain A, Jasinski M, Jouan J, Kalil RAK, Menicanti L, Michler RE, Rao V, Smith PK, Zembala M, Velazquez EJ, Al-Khalidi HR, Rouleau JL, Investigators F. Society of Thoracic Surgeons Risk Score and EuroSCORE-2 Appropriately Assess 30-Day Postoperative Mortality in the STICH Trial and a Contemporary Cohort of Patients With Left Ventricular Dysfunction Undergoing Surgical Revascularization. Circulation Heart Failure 2018, 11: e005531. PMID: 30571194, PMCID: PMC6309904, DOI: 10.1161/circheartfailure.118.005531.Peer-Reviewed Original ResearchConceptsPostoperative mortality riskCoronary artery bypassThoracic Surgeons risk scoreEuroScore 2Left ventricular dysfunctionContemporary cohortVentricular dysfunctionArtery bypassSTS scoreMortality riskRisk scoreSTICH patientsSTICH trialPostoperative mortalityUndergoing coronary artery bypassLeft ventricle ejection fractionVentricle ejection fractionGood c-statisticLow-risk scoresSurgical revascularizationSurvival benefitCardiac surgeryConsecutive patientsEjection fractionCC patientsThe relationship between baseline and follow-up left ventricular ejection fraction with adverse events among primary prevention ICD patients
Friedman DJ, Fudim M, Overton R, Shaw LK, Patel D, Pokorney SD, Velazquez EJ, Al-Khatib SM. The relationship between baseline and follow-up left ventricular ejection fraction with adverse events among primary prevention ICD patients. American Heart Journal 2018, 201: 17-24. PMID: 29910051, PMCID: PMC6309220, DOI: 10.1016/j.ahj.2018.03.017.Peer-Reviewed Original ResearchConceptsLeft ventricular assist devicePrimary prevention ICD patientsAppropriate ICD therapyVentricular ejection fractionImplantable cardioverter defibrillatorICD therapyICD implantationEjection fractionICD patientsMultivariable Cox proportional hazards modelsPrimary prevention implantable cardioverter defibrillatorsCo-primary study endpointsPrimary prevention ICD recipientsFollow-up left ventricular ejection fractionLeft ventricular ejection fractionCox proportional hazards modelComposite of timeLong-term followProportional hazards modelVentricular assist deviceLong-term riskBaseline LVEFLVEF improvementAdverse eventsComposite endpointSex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization
Piña IL, Zheng Q, She L, Szwed H, Lang IM, Farsky PS, Castelvecchio S, Biernat J, Paraforos A, Kosevic D, Favaloro LE, Nicolau JC, Varadarajan P, Velazquez EJ, Pai RG, Cyrille N, Lee KL, Desvigne-Nickens P. Sex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization. Circulation 2018, 137: 771-780. PMID: 29459462, PMCID: PMC5896331, DOI: 10.1161/circulationaha.117.030526.Peer-Reviewed Original ResearchConceptsIschemic left ventricular dysfunctionLeft ventricular dysfunctionCause mortalityCardiovascular mortalitySTICH trialSurgical deathsVentricular dysfunctionCardiovascular hospitalizationRisk factorsKansas City Cardiomyopathy Questionnaire overall summary scoreHigher New York Heart Association classCardiac Operative Risk Evaluation scoreCoronary artery disease risk factorsNew York Heart Association classHigher body mass indexComposite of deathCoronary artery bypassIschemic heart failureDisease risk factorsPoor prognostic factorVentricular ejection fractionCoronary artery diseaseBody mass indexLong-term outcomesOverall summary scorePrior Medications and the Cardiovascular Benefits From Combination Angiotensin‐Converting Enzyme Inhibition Plus Calcium Channel Blockade Among High‐Risk Hypertensive Patients
Brook RD, Kaciroti N, Bakris G, Dahlöf B, Pitt B, Velazquez E, Weber M, Zappe DH, Hau T, Jamerson KA. Prior Medications and the Cardiovascular Benefits From Combination Angiotensin‐Converting Enzyme Inhibition Plus Calcium Channel Blockade Among High‐Risk Hypertensive Patients. Journal Of The American Heart Association 2018, 7: e006940. PMID: 29301757, PMCID: PMC5778960, DOI: 10.1161/jaha.117.006940.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmlodipineAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBenzazepinesBlood PressureCalcium Channel BlockersCause of DeathDrug Therapy, CombinationFemaleHumansHydrochlorothiazideHypertensionMaleMiddle AgedRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsSodium Chloride Symporter InhibitorsTime FactorsTreatment OutcomeConceptsHigh-risk hypertensive patientsCardiovascular risk reductionHypertensive patientsAntihypertensive regimenCombination therapyBlood pressure control statusGreater cardiovascular risk reductionRenin-angiotensin system blockadeAngiotensin-converting enzyme inhibitorPrimary composite eventsPrior antihypertensive therapyPrimary composite outcomeCalcium channel blockadeLipid-lowering medicationsPrior medication useCalcium channel blockersRisk reductionACCOMPLISH trialAntihypertensive therapySystem blockadeCardiovascular benefitsCombination regimenComposite outcomeDrug regimensMedication use
2017
Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND‐HF
Pokorney SD, Al‐Khatib S, Sun J, Schulte P, O'Connor CM, Teerlink JR, Armstrong PW, Ezekowitz JA, Starling RC, Voors AA, Velazquez EJ, Hernandez AF, Mentz RJ. Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND‐HF. European Journal Of Heart Failure 2017, 20: 525-532. PMID: 29266564, DOI: 10.1002/ejhf.1078.Peer-Reviewed Original ResearchConceptsSudden cardiac deathVT/VFHeart failure hospital admissionsAcute HFCardiac deathHospital admissionVentricular tachycardia/ventricular fibrillationDecompensated Heart Failure (ASCEND-HF) trialChronic obstructive pulmonary diseaseVT/VF eventsEvent ratesComposite event rateMeier event ratesHeart Failure TrialCause mortality ratesDay of admissionObstructive pulmonary diseaseLonger QRS durationCause mortalityBaseline characteristicsComposite endpointEjection fractionPulmonary diseaseASCEND-HFFailure TrialPrevalence and Outcomes of Left‐Sided Valvular Heart Disease Associated With Chronic Kidney Disease
Samad Z, Sivak JA, Phelan M, Schulte PJ, Patel U, Velazquez EJ. Prevalence and Outcomes of Left‐Sided Valvular Heart Disease Associated With Chronic Kidney Disease. Journal Of The American Heart Association 2017, 6: e006044. PMID: 29021274, PMCID: PMC5721834, DOI: 10.1161/jaha.117.006044.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAortic ValveAortic Valve StenosisComorbidityDatabases, FactualEchocardiographyFemaleGlomerular Filtration RateHumansKaplan-Meier EstimateKidneyMaleMiddle AgedMitral ValveMitral Valve InsufficiencyNorth CarolinaPrevalencePrognosisProportional Hazards ModelsRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsConceptsChronic kidney diseaseFive-year survival estimatesNon-CKD patientsCKD patientsMitral regurgitationMR severityKidney diseaseSurvival estimatesCoronary artery bypassGlomerular filtration ratePercutaneous coronary interventionSevere mitral regurgitationValvular heart diseaseSerum creatinine valuesAdverse prognostic markerRegurgitant valve lesionsIndex echocardiogramSevere ASArtery bypassIntervention patientsValve lesionsValve surgeryCoronary interventionHazard ratioHeart failureClinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya
Temu TM, Lane KA, Shen C, Ng'ang'a L, Akwanalo CO, Chen PS, Emonyi W, Heckbert SR, Koech MM, Manji I, Vatta M, Velazquez EJ, Wessel J, Kimaiyo S, Inui TS, Bloomfield GS. Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya. PLOS ONE 2017, 12: e0185204. PMID: 28934312, PMCID: PMC5608343, DOI: 10.1371/journal.pone.0185204.Peer-Reviewed Original ResearchConceptsValvular AFValvular heart diseaseAtrial fibrillationNVAF patientsAF patientsHeart diseaseNon-valvular atrial fibrillationGlobal cardiovascular disease burdenValvular atrial fibrillationRates of hypertensionCardiovascular disease burdenLong-term outcomesProspective data collectionAnticoagulation therapyClinical characteristicsCohort studyClinical profileHeart failureOverall mortalityClinical featuresComorbid conditionsFatal outcomeMean ageFemale sexDisease burdenSafety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose
Lu MT, Douglas PS, Udelson JE, Adami E, Ghoshhajra BB, Picard MH, Roberts R, Lee KL, Einstein AJ, Mark DB, Velazquez EJ, Carter W, Ridner M, Al-Khalidi HR, Hoffmann U. Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose. Journal Of Cardiovascular Computed Tomography 2017, 11: 373-382. PMID: 28838846, PMCID: PMC6201309, DOI: 10.1016/j.jcct.2017.08.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina PectorisComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEchocardiography, StressFemaleHumansIncidental FindingsMaleMiddle AgedMultidetector Computed TomographyNorth AmericaPredictive Value of TestsProspective StudiesRadiation DosageRadiation ExposureRadionuclide ImagingRisk AssessmentRisk FactorsConceptsStable chest painMore incidental findingsIncidental findingLow radiation doseChest painPatient characteristicsRadiation doseNuclear stress testingCoronary CT angiographyRadiation dose variesCumulative radiation doseAdvanced CT scannersMinor complicationsPROMISE trialRandomized comparisonTomography angiographyFunctional testingTest choiceFunctional testing strategyCT angiographyNuclear stressPulmonary nodulesSimilar outcomesComplicationsDoseLeft ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: outcomes following an acute heart failure hospitalization
Buggey J, Alenezi F, Yoon HJ, Phelan M, DeVore AD, Khouri MG, Schulte PJ, Velazquez EJ. Left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: outcomes following an acute heart failure hospitalization. ESC Heart Failure 2017, 4: 432-439. PMID: 29154416, PMCID: PMC5695196, DOI: 10.1002/ehf2.12159.Peer-Reviewed Original ResearchConceptsAcute heart failure hospitalizationVentricular global longitudinal strainAbnormal LV-GLSLV-GLSHeart failure hospitalizationGlobal longitudinal strainAcute HFpEFFailure hospitalizationEjection fractionHeart failureLongitudinal strainCox proportional hazards modelDuke University Medical CenterComposite of mortalityMedian LV-GLSWorse LV-GLSChronic heart failureWorse clinical outcomesMyocardial systolic dysfunctionSpeckle-tracking analysisProportional hazards modelUniversity Medical CenterMultivariable adjustmentSystolic dysfunctionBaseline characteristicsComparison of Clinical Characteristics and Outcomes of Patients With Versus Without Diabetes Mellitus and With Versus Without Angina Pectoris (from the Duke Databank for Cardiovascular Disease)
Banks A, Broderick S, Chiswell K, Shaw L, Devore A, Fiuzat M, O'Connor C, Felker GM, Velazquez E, Mentz R. Comparison of Clinical Characteristics and Outcomes of Patients With Versus Without Diabetes Mellitus and With Versus Without Angina Pectoris (from the Duke Databank for Cardiovascular Disease). The American Journal Of Cardiology 2017, 119: 1703-1709. PMID: 28395884, DOI: 10.1016/j.amjcard.2017.02.053.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseAngina pectorisDiabetes mellitusDM statusCause mortalityMultivariable Cox regressionOutcomes of patientsDifferent prognostic implicationsSeverity of diseaseAP statusCV hospitalizationClinical characteristicsArtery diseaseCoronary angiographyDM patientsClinical outcomesCox regressionPrognostic implicationsPrognostic utilityRevascularizationSimilar riskPatientsRisk adjustmentMortalityPectorisSudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting
Rao MP, Al-Khatib SM, Pokorney SD, She L, Romanov A, Nicolau JC, Lee KL, Carson P, Selzman CH, Stepinska J, Cleland JG, Tungsubutra W, Desvigne-Nickens PM, Sueta CA, Siepe M, Lang I, Feldman AM, Yii M, Rouleau JL, Velazquez EJ. Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting. Circulation 2017, 135: 1136-1144. PMID: 28154006, PMCID: PMC5516272, DOI: 10.1161/circulationaha.116.026075.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationCoronary Artery BypassDeath, Sudden, CardiacFemaleFollow-Up StudiesHeart FailureHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainPostoperative PeriodProportional Hazards ModelsReceptors, Tumor Necrosis FactorRisk FactorsStroke VolumeVentricular Function, LeftConceptsCoronary artery bypass graft surgerySudden cardiac deathEnd-systolic volume indexB-type natriuretic peptideVentricular ejection fractionSurgical ventricular reconstructionCardiac deathEjection fractionHeart failureNatriuretic peptideVentricular reconstructionPreoperative end-systolic volume indexLow left ventricular ejection fractionIncidence of SCDPredictors of SCDArtery bypass graft surgeryCoronary Artery Bypass GraftingLeft ventricular ejection fractionVolume indexArtery Bypass GraftingBypass graft surgeryIschemic heart failureContemporary clinical trialsBlinded committeeSTICH trialMental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients
Sun JL, Boyle SH, Samad Z, Babyak MA, Wilson JL, Kuhn C, Becker RC, Ortel TL, Williams RB, Rogers JG, O’Connor C, Velazquez EJ, Jiang W. Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients. European Journal Of Preventive Cardiology 2017, 24: 591-599. PMID: 28067532, PMCID: PMC6093615, DOI: 10.1177/2047487316686435.Peer-Reviewed Original ResearchMeSH KeywordsAgedCitalopramDisease-Free SurvivalFemaleHumansMaleMental HealthMiddle AgedMultivariate AnalysisMyocardial IschemiaProportional Hazards ModelsRisk AssessmentRisk FactorsSelective Serotonin Reuptake InhibitorsStress, PsychologicalStroke VolumeTime FactorsTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsMental stress-induced myocardial ischemiaMajor adverse cardiovascular eventsAdverse cardiovascular eventsLeft ventricular ejection fraction changeVentricular ejection fraction changeStable ischemic heart diseaseIschemic heart disease patientsLeft ventricular ejection fractionStress-induced myocardial ischemiaEjection fraction changesVentricular ejection fractionIschemic heart diseaseCardiovascular eventsHeart disease patientsMyocardial ischemiaEjection fractionStudy endpointDisease patientsHeart diseaseMental Stress–Induced Myocardial IschemiaStress-induced left ventricular dysfunctionFuture adverse cardiovascular eventsLeft ventricular dysfunctionHeart failure statusAssociation of indices
2016
Cardiovascular Outcomes According to Systolic Blood Pressure in Patients With and Without Diabetes: An ACCOMPLISH Substudy
Weber MA, Bloch M, Bakris GL, Weir MR, Zappe DH, Dahlof B, Velazquez EJ, Pitt B, Basile JN, Jamerson K, Hua TA. Cardiovascular Outcomes According to Systolic Blood Pressure in Patients With and Without Diabetes: An ACCOMPLISH Substudy. Journal Of Clinical Hypertension 2016, 18: 299-307. PMID: 27060568, PMCID: PMC8032014, DOI: 10.1111/jch.12816.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureBlood Pressure DeterminationDiabetes Mellitus, Type 2Double-Blind MethodDrug Therapy, CombinationFemaleFollow-Up StudiesHumansHypertensionIncidenceMaleMyocardial InfarctionProspective StudiesRisk AssessmentRisk FactorsStrokeSurvival RateSystoleTreatment OutcomeUnited StatesConceptsSystolic blood pressureNondiabetic cohortCardiovascular outcomesPrimary endpointBlood pressurePrimary endpoint event rateTreatment systolic blood pressureEvent ratesAvoiding Cardiovascular EventsBlood pressure targetsDifferent SBP targetsFurther SBP reductionSystolic Hypertension (ACCOMPLISH) trialAdverse renal eventsComposite primary endpointTotal stroke ratesCV protectionNondiabetic patientsRenal considerationsRenal eventsSBP categoriesSBP reductionCardiovascular eventsHypertension trialsPressure targetsMarkers of Atherosclerosis, Clinical Characteristics, and Treatment Patterns in Heart Failure A Case-Control Study of Middle-Aged Adult Heart Failure Patients in Rural Kenya
Bloomfield GS, DeLong AK, Akwanalo CO, Hogan JW, Carter EJ, Aswa DF, Binanay C, Koech M, Kimaiyo S, Velazquez EJ. Markers of Atherosclerosis, Clinical Characteristics, and Treatment Patterns in Heart Failure A Case-Control Study of Middle-Aged Adult Heart Failure Patients in Rural Kenya. Global Heart 2016, 11: 97-107. PMID: 27102027, PMCID: PMC4843836, DOI: 10.1016/j.gheart.2015.12.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAtherosclerosisBiomarkersCardiomyopathy, DilatedCase-Control StudiesDyslipidemiasEchocardiographyElectrocardiographyFemaleGuideline AdherenceHeart FailureHumansHypertensionKenyaLogistic ModelsMaleMiddle AgedMyocardial IschemiaOdds RatioPractice Guidelines as TopicRisk FactorsRural PopulationConceptsAnkle-brachial indexAtherosclerotic risk factorsIschemic heart failureHeart failureCase-control studyWall motion abnormalitiesRisk factorsMotion abnormalitiesAdult heart failure patientsHuman immunodeficiency virus (HIV) infectionA Case-Control StudyContribution of atherosclerosisImmunodeficiency virus infectionMarker of atherosclerosisHeart failure patientsMultivariable logistic regressionPhysical examination findingsConfidence intervalsRural KenyaIschemic patternLipid testingClinical characteristicsFailure patientsMost patientsExamination findings
2015
Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization
Bonow RO, Castelvecchio S, Panza JA, Berman DS, Velazquez EJ, Michler RE, She L, Holly TA, Desvigne-Nickens P, Kosevic D, Rajda M, Chrzanowski L, Deja M, Lee KL, White H, Oh JK, Doenst T, Hill JA, Rouleau JL, Menicanti L, Investigators S. Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization. JACC Cardiovascular Imaging 2015, 8: 1121-1129. PMID: 26363840, PMCID: PMC4633018, DOI: 10.1016/j.jcmg.2015.03.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassCoronary Artery DiseaseEchocardiography, StressFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardiumPredictive Value of TestsProportional Hazards ModelsProspective StudiesRecovery of FunctionRisk FactorsStroke VolumeTime FactorsTissue SurvivalTomography, Emission-Computed, Single-PhotonTreatment OutcomeUnited StatesVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingConceptsEnd-systolic volume indexEnd-systolic volumeEffect of CABGIschemic LV dysfunctionMedical therapyMyocardial viabilityLV dysfunctionViable myocardiumLV end-systolic volume indexMedian end-systolic volume indexSmaller end-systolic volumeCoronary artery bypassLV systolic dysfunctionMarker of severityCoronary artery diseaseLeft ventricular remodelingPre-specified criteriaSingle photon emissionSTICH trialSurgical revascularizationArtery bypassDobutamine echocardiographySystolic dysfunctionArtery diseaseIschemic cardiomyopathyHuman Immunodeficiency Virus and Heart Failure in Low- and Middle-Income Countries
Bloomfield GS, Alenezi F, Barasa FA, Lumsden R, Mayosi BM, Velazquez EJ. Human Immunodeficiency Virus and Heart Failure in Low- and Middle-Income Countries. JACC Heart Failure 2015, 3: 579-590. PMID: 26251085, PMCID: PMC4530470, DOI: 10.1016/j.jchf.2015.05.003.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHeart failureMiddle-income countriesImmunodeficiency virusChronic diseasesBurden of HIVTraditional cardiovascular risk factorsCommon cardiac diagnosesCardiovascular risk factorsLarge observational studiesLife expectancySuccessful combination therapyCare of peopleAntiretroviral therapyClinical characteristicsTreatment patternsSociety guidelinesCombination therapyRisk factorsClinical studiesObservational studyDiagnostic criteriaCardiac diagnosisHigh mortalityCardiac glycosidesGenetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL)
Bloomfield GS, Temu TM, Akwanalo CO, Chen PS, Emonyi W, Heckbert SR, Koech MM, Manji I, Shen C, Vatta M, Velazquez EJ, Wessel J, Kimaiyo S, Inui TS. Genetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL). American Heart Journal 2015, 170: 455-464.e5. PMID: 26385028, PMCID: PMC4575772, DOI: 10.1016/j.ahj.2015.06.008.Peer-Reviewed Original ResearchConceptsValvular atrial fibrillationNonvalvular atrial fibrillationValvular heart diseaseAtrial fibrillationHeart diseaseCurrent tobacco smokingHistory of strokeCase-control studyGroup morbidityGenetic associationTobacco smokingSaharan AfricaMean ageAfrican patientsCardiovascular diseaseClinical phenotypingFibrillationPrimary analysisPatientsControl populationGenetic testingMorbidityDiseaseGenetic mutationsMost participantsTorsemide Versus Furosemide in Heart Failure Patients
Mentz RJ, Buggey J, Fiuzat M, Ersbøll MK, Schulte PJ, DeVore AD, Eisenstein EL, Anstrom KJ, O'Connor C, Velazquez EJ. Torsemide Versus Furosemide in Heart Failure Patients. Journal Of Cardiovascular Pharmacology 2015, 65: 438-443. PMID: 25945862, PMCID: PMC4423558, DOI: 10.1097/fjc.0000000000000212.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedComorbidityDatabases, FactualFemaleFurosemideHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedNorth CarolinaRetrospective StudiesRisk FactorsSex FactorsSodium Potassium Chloride Symporter InhibitorsSulfonamidesTertiary Care CentersTorsemideTreatment OutcomeUltrasonographyConceptsHeart failure patientsFailure patientsEffects of torsemideFurosemide-treated patientsMore comorbiditiesCause mortalityBaseline characteristicsProspective trialHeart failureLoop diureticsResidual confoundingPatientsDuke HospitalFurosemideRisk adjustmentTorsemideMortalityLab databaseComorbiditiesDiureticsHospitalTrials