2013
The STICH Trial (Surgical Treatment for Ischemic Heart Failure) Mode-of-Death Results
Carson P, Wertheimer J, Miller A, O'Connor CM, Pina IL, Selzman C, Sueta C, She L, Greene D, Lee KL, Jones RH, Velazquez EJ, Investigators S. The STICH Trial (Surgical Treatment for Ischemic Heart Failure) Mode-of-Death Results. JACC Heart Failure 2013, 1: 400-408. PMID: 24621972, PMCID: PMC3829618, DOI: 10.1016/j.jchf.2013.04.012.Peer-Reviewed Original ResearchConceptsMode of deathIschemic cardiomyopathy patientsMedical therapySTICH trialMyocardial infarction deathsCABG therapyCardiomyopathy patientsSudden deathProspective clinical trial dataAddition of CABGStrategy of CABGCoronary artery bypassReduced ejection fractionClinical events committeeClinical trial dataPre-specified definitionsCABG patientsArtery bypassCardiovascular deathNoncardiovascular deathEjection fractionHeart failureEvents committeeProtective effectCABG
2011
Circumstances and Outcomes of Sudden Unexpected Death in Patients With High-Risk Myocardial Infarction
Ye S, Grunnert M, Thune JJ, Stephenson KM, Uno H, Finn PV, McMurray JJ, Velazquez EJ, Califf R, Pfeffer MA, Solomon SD. Circumstances and Outcomes of Sudden Unexpected Death in Patients With High-Risk Myocardial Infarction. Circulation 2011, 123: 2674-2680. PMID: 21606398, DOI: 10.1161/circulationaha.110.990655.Peer-Reviewed Original ResearchConceptsHigh-risk myocardial infarctionSudden deathMyocardial infarctionHospital eventsVentricular tachycardia/ventricular fibrillationPrevention of SDSD eventsLong-term mortalityMajority of patientsSudden unexpected deathInitial ECG rhythmCatastrophic complicationUnwitnessed arrestsUnexpected deathVentricular fibrillationTrial trialsPatientsInfarctionECG rhythmDeathPreventionHigher proportionHome eventsArrestSource documentation
2010
Pathogenesis of Sudden Unexpected Death in a Clinical Trial of Patients With Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both
Pouleur AC, Barkoudah E, Uno H, Skali H, Finn PV, Zelenkofske SL, Belenkov YN, Mareev V, Velazquez EJ, Rouleau JL, Maggioni AP, Køber L, Califf RM, McMurray JJ, Pfeffer MA, Solomon SD. Pathogenesis of Sudden Unexpected Death in a Clinical Trial of Patients With Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both. Circulation 2010, 122: 597-602. PMID: 20660803, DOI: 10.1161/circulationaha.110.940619.Peer-Reviewed Original ResearchConceptsSudden unexpected deathRecurrent MISudden deathArrhythmic deathAutopsy recordsUnexpected deathAcute Myocardial Infarction trialImplantable cardioverter-defibrillator therapyEarly post-myocardial infarction periodPost-myocardial infarction periodMyocardial Infarction trialCardioverter-defibrillator therapySudden death eventsIndex MILack of benefitSeries of casesCardiovascular causesNoncardiovascular causesVentricular dysfunctionAcute MICardiac ruptureHeart failureAutopsy evidenceClinical groundsAutopsy findings
2008
Usefulness of Right Ventricular Fractional Area Change to Predict Death, Heart Failure, and Stroke Following Myocardial Infarction (from the VALIANT ECHO Study)
Anavekar NS, Skali H, Bourgoun M, Ghali JK, Kober L, Maggioni AP, McMurray JJ, Velazquez E, Califf R, Pfeffer MA, Solomon SD. Usefulness of Right Ventricular Fractional Area Change to Predict Death, Heart Failure, and Stroke Following Myocardial Infarction (from the VALIANT ECHO Study). The American Journal Of Cardiology 2008, 101: 607-612. PMID: 18308007, DOI: 10.1016/j.amjcard.2007.09.115.Peer-Reviewed Original ResearchConceptsRight ventricular fractional area changeVentricular fractional area changeRight ventricular functionHeart failureFractional area changeMyocardial infarctionClinical outcomesSudden deathCause mortalityVentricular dysfunctionEjection fractionVentricular functionBaseline right ventricular functionRight ventricular systolic functionSevere right ventricular dysfunctionLeft ventricular ejection fractionRecurrent myocardial infarctionRight ventricular dysfunctionLeft ventricular dysfunctionVentricular systolic functionVentricular ejection fractionMajor risk factorTwo-dimensional echocardiogramsCV deathCV outcomes
2006
Association of QRS duration and outcomes after myocardial infarction: the VALIANT trial
Yerra L, Anavekar N, Skali H, Zelenkofske S, Velazquez E, McMurray J, Pfeffer M, Solomon SD. Association of QRS duration and outcomes after myocardial infarction: the VALIANT trial. Heart Rhythm 2006, 3: 313-316. PMID: 16500304, DOI: 10.1016/j.hrthm.2005.11.024.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsCohort StudiesElectrocardiographyFemaleFollow-Up StudiesHeart VentriclesHumansMaleMiddle AgedMyocardial InfarctionPrognosisStroke VolumeSurvival RateTetrazolesTreatment OutcomeValineValsartanVentricular Dysfunction, LeftConceptsQRS durationSudden deathCV deathAdverse outcomesMyocardial infarctionPost-myocardial infarction settingUnivariate relative riskLeft ventricular dysfunctionHeart failure patientsSymptoms of HFAcute myocardial infarctionDevelopment of HFEnd-systolic volumeLarger ventricular volumesQRS duration prolongationRecurrent MICardiovascular deathInitial electrocardiogramVentricular dysfunctionAcute MIFailure patientsSystolic functionEjection fractionIndependent predictorsClinical outcomes
2005
Sudden Death in Patients with Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both
Solomon SD, Zelenkofske S, McMurray JJ, Finn PV, Velazquez E, Ertl G, Harsanyi A, Rouleau JL, Maggioni A, Kober L, White H, Van de Werf F, Pieper K, Califf RM, Pfeffer MA. Sudden Death in Patients with Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both. New England Journal Of Medicine 2005, 352: 2581-2588. PMID: 15972864, DOI: 10.1056/nejmoa043938.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionLeft ventricular dysfunctionMyocardial infarctionCardiac arrestSudden deathVentricular dysfunctionEjection fractionHeart failureLeft ventricular systolic functionHigh-risk patientsVentricular systolic functionSudden unexpected deathAcute myocardial infarctionCardiac causesHospital dischargeSystolic functionPercent confidence intervalsUnexpected deathHigh riskInfarctionPatientsResuscitationDysfunctionDeath