2020
Implications of Abnormal Exercise Electrocardiography With Normal Stress Echocardiography
Daubert MA, Sivak J, Dunning A, Douglas PS, Coyne B, Wang TY, Mark DB, Velazquez EJ. Implications of Abnormal Exercise Electrocardiography With Normal Stress Echocardiography. JAMA Internal Medicine 2020, 180: 494-502. PMID: 31985749, PMCID: PMC6990669, DOI: 10.1001/jamainternmed.2019.6958.Peer-Reviewed Original ResearchConceptsNormal stress echocardiographyComposite end pointStress echoExercise electrocardiographyStress echocardiographyMyocardial infarctionDownstream testingEnd pointDuke University Medical CenterExercise stress echoNegative exercise ECGStress ECG findingsAdverse cardiac eventsIncremental prognostic valueObservational cohort studyAdverse clinical eventsCoronary artery diseaseIndividual adverse eventsPopulation of patientsUniversity Medical CenterImaging resultsCoronary revascularizationAdverse eventsCardiac eventsCohort study
2019
PCI and CABG for Treating Stable Coronary Artery Disease JACC Review Topic of the Week
Doenst T, Haverich A, Serruys P, Bonow RO, Kappetein P, Falk V, Velazquez E, Diegeler A, Sigusch H. PCI and CABG for Treating Stable Coronary Artery Disease JACC Review Topic of the Week. Journal Of The American College Of Cardiology 2019, 73: 964-976. PMID: 30819365, DOI: 10.1016/j.jacc.2018.11.053.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionMyocardial infarctionStable coronary artery diseaseMajority of infarctsCoronary artery bypassCoronary artery diseaseFlow-limiting lesionsNew infarctsArtery bypassCoronary interventionInfarct reductionArtery diseaseMedical therapyRevascularization proceduresVessel occlusionCABGSurvival effectReview TopicTreatment effectsInfarctionInfarctsIschemia detectionRevascularizationStenosisBypass
2017
Adverse Remodeling and Reverse Remodeling After Myocardial Infarction
Bhatt AS, Ambrosy AP, Velazquez EJ. Adverse Remodeling and Reverse Remodeling After Myocardial Infarction. Current Cardiology Reports 2017, 19: 71. PMID: 28660552, DOI: 10.1007/s11886-017-0876-4.Peer-Reviewed Original ResearchConceptsAdverse LV remodelingMyocardial infarctionLV remodelingAdverse remodelingNeurohormonal regulationLeft ventricleCurrent evidence-based therapiesPost-MI heart failurePoor clinical outcomeAdverse cardiac remodelingPost-MI settingDevice-based therapiesEvidence-based therapiesNeurohormonal blockadeEarly revascularizationPathophysiological considerationsHeart failureVentricular dyssynchronyClinical outcomesEjection fractionMultiple imaging modalitiesCardiac remodelingTreatment strategiesReviewThe purposeInfarction
2016
Reassessment of Cardiac Function and Implantable Cardioverter-Defibrillator Use Among Medicare Patients With Low Ejection Fraction After Myocardial Infarction
Pokorney SD, Miller AL, Chen AY, Thomas L, Fonarow GC, de Lemos JA, Al-Khatib SM, Velazquez EJ, Peterson ED, Wang TY. Reassessment of Cardiac Function and Implantable Cardioverter-Defibrillator Use Among Medicare Patients With Low Ejection Fraction After Myocardial Infarction. Circulation 2016, 135: 38-47. PMID: 27881561, DOI: 10.1161/circulationaha.116.022359.Peer-Reviewed Original ResearchMeSH KeywordsAgedDatabases, FactualDefibrillators, ImplantableFemaleHeart VentriclesHumansMagnetic Resonance ImagingMaleMedicareMyocardial InfarctionMyocardial RevascularizationProportional Hazards ModelsRegistriesRetrospective StudiesStroke VolumeSurvival RateTomography, X-Ray ComputedUltrasonographyUnited StatesConceptsLow ejection fractionEjection fractionICD implantationMyocardial infarctionMI admissionsRevascularization statusImplantable cardioverter-defibrillator (ICD) useACTION Registry-GWTGICD implantation ratesMultivariable Cox modelPost-MI patientsYears of ageImplantation rateCardiac functionMedicare patientsCox modelPatientsAdmissionHigher likelihoodInfarctionImplantationAssociationYearsStatusICDPredicting Outcomes Over Time in Patients With Heart Failure, Left Ventricular Systolic Dysfunction, or Both Following Acute Myocardial Infarction
Lopes RD, Pieper KS, Stevens SR, Solomon SD, McMurray JJ, Pfeffer MA, Leimberger JD, Velazquez EJ. Predicting Outcomes Over Time in Patients With Heart Failure, Left Ventricular Systolic Dysfunction, or Both Following Acute Myocardial Infarction. Journal Of The American Heart Association 2016, 5: e003045. PMID: 27353607, PMCID: PMC4937254, DOI: 10.1161/jaha.115.003045.Peer-Reviewed Original ResearchConceptsVentricular systolic dysfunctionHeart failureMyocardial infarctionIntegrated discrimination improvementSystolic dysfunctionCardiovascular deathMultivariable Cox proportional hazardsAcute Myocardial Infarction trialNet reclassification improvement indexNonfatal heart failureMyocardial Infarction trialNonfatal myocardial infarctionPredictors of mortalityPatient informationBaseline heart rateAcute myocardial infarctionCox proportional hazardsCreatinine clearanceHospital arrivalHospital dischargeIndex hospitalizationPatient characteristicsOverall mortalityIndex eventClinical eventsEffect of single and dual renin-angiotensin blockade on stroke in patients with and without diabetes in VALIANT
Abdul-Rahim AH, Docherty KF, Skali H, Køber L, Dickstein K, Maggioni AP, Mareev V, Zannad F, Velazquez EJ, Califf RM, Pfeffer MA, Solomon SD, Lees KR, McMurray JJ. Effect of single and dual renin-angiotensin blockade on stroke in patients with and without diabetes in VALIANT. European Stroke Journal 2016, 1: 93-100. PMID: 31008270, PMCID: PMC6301225, DOI: 10.1177/2396987316646025.Peer-Reviewed Original ResearchAngiotensin receptor blockersRisk of strokeAcute myocardial infarctionMyocardial infarctionReceptor blockersDual renin-angiotensin system blockadeEnzyme inhibitorsDual renin-angiotensin blockadeRenin-angiotensin system blockadeAcute Myocardial Infarction trialCox proportional hazards regressionRenin-angiotensin blockadeMyocardial Infarction trialRate of strokeVentricular systolic dysfunctionProportional hazards regressionRenin inhibitor aliskirenSystem blockadeSystolic dysfunctionHazard ratioHeart failureTreatment groupsPatientsDiabetesStroke
2015
Clinical predictors and outcomes of patients with left ventricular thrombus following ST-segment elevation myocardial infarction
Garber AM, Mentz RJ, Al-Khalidi HR, Shaw LK, Fiuzat M, O’Connor C, Velazquez EJ. Clinical predictors and outcomes of patients with left ventricular thrombus following ST-segment elevation myocardial infarction. Journal Of Thrombosis And Thrombolysis 2015, 41: 365-373. PMID: 26202909, DOI: 10.1007/s11239-015-1252-0.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionNon-white raceHF severityBaseline characteristicsClinical predictorsHeart failureIndependent predictorsMyocardial infarctionHeart rateCox proportional hazards regression modelProportional hazards regression modelsLeft ventricular thrombusLong-term mortalityOutcomes of patientsVentricular thrombus formationHazards regression modelsHigher heart rateEligible patientsInitial troponinCause mortalityLAD diseaseSTEMI patientsVentricular thrombusTransthoracic echocardiogramSex differences in clinical characteristics and outcomes after myocardial infarction: insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT)
Lam CS, McEntegart M, Claggett B, Liu J, Skali H, Lewis E, Køber L, Rouleau J, Velazquez E, Califf R, McMurray JJ, Pfeffer M, Solomon S. Sex differences in clinical characteristics and outcomes after myocardial infarction: insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT). European Journal Of Heart Failure 2015, 17: 301-312. PMID: 25655011, DOI: 10.1002/ejhf.238.Peer-Reviewed Original ResearchConceptsAcute Myocardial Infarction trialMyocardial Infarction trialVentricular systolic dysfunctionHeart failureMyocardial infarctionSystolic dysfunctionClinical characteristicsVentricular volumeKillip class III/IVLeft ventricular systolic dysfunctionRisk of HFClass III/IVHigher long-term riskSmaller left ventricular volumesSimilar ejection fractionLong-term mortalityPost-infarction anginaRisk of hospitalizationSubset of patientsNon-fatal outcomesLong-term riskLeft ventricular volumeAssociation of sexMore comorbiditiesCardiovascular death
2014
HIV and Noncommunicable Cardiovascular and Pulmonary Diseases in Low- and Middle-Income Countries in the ART Era
Bloomfield GS, Khazanie P, Morris A, Rabadán-Diehl C, Benjamin LA, Murdoch D, Radcliff VS, Velazquez EJ, Hicks C. HIV and Noncommunicable Cardiovascular and Pulmonary Diseases in Low- and Middle-Income Countries in the ART Era. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: s40-s53. PMID: 25117960, PMCID: PMC4133739, DOI: 10.1097/qai.0000000000000257.Peer-Reviewed Original ResearchConceptsHIV-positive patientsAntiretroviral therapyHIV infectionMiddle-income countriesPulmonary diseaseCoronary artery disease/myocardial infarctionLong-term HIV infectionEffective antiretroviral therapyHIV-seropositive patientsLong-term morbidityPulmonary arterial hypertensionObstructive lung diseaseHIV-positive personsLong-term outcomesChronic noncommunicable diseasesEffective prevention strategiesPotential adverse effectsPulmonary complicationsArterial hypertensionHeart failureLung diseasePulmonary conditionsMyocardial infarctionEarly recognitionART eraImpact of Cardiovascular Events on Change in Quality of Life and Utilities in Patients After Myocardial Infarction A VALIANT Study (Valsartan In Acute Myocardial Infarction)
Lewis EF, Li Y, Pfeffer MA, Solomon SD, Weinfurt KP, Velazquez EJ, Califf RM, Rouleau JL, Kober L, White HD, Schulman KA, Reed SD. Impact of Cardiovascular Events on Change in Quality of Life and Utilities in Patients After Myocardial Infarction A VALIANT Study (Valsartan In Acute Myocardial Infarction). JACC Heart Failure 2014, 2: 159-165. PMID: 24720924, DOI: 10.1016/j.jchf.2013.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAngiotensin II Type 1 Receptor BlockersAngiotensin-Converting Enzyme InhibitorsBundle-Branch BlockCaptoprilDeath, Sudden, CardiacDrug Therapy, CombinationFemaleHealth StatusHeart FailureHospitalizationHumansMaleMyocardial InfarctionQuality of LifeRecurrenceStrokeSurvivorsTetrazolesTreatment OutcomeValineValsartanConceptsNonfatal CV eventsEQ-5D assessmentCV eventsVisual analog scaleEQ-5D scoresCardiovascular eventsMyocardial infarctionEQ-5DBaseline EQ-5D scoresKillip class IINonfatal cardiovascular eventsHealth-related qualityLinear mixed-effects regression modelsQuality of lifeMixed effects regression modelsVALIANT studyWorse HRQLVAS scoresEjection fractionNonfatal eventsMI survivorsAnalog scaleVALIANT trialGeneric instrumentsPatientsPROspective Multicenter Imaging Study for Evaluation of chest pain: Rationale and design of the PROMISE trial
Douglas PS, Hoffmann U, Lee KL, Mark DB, Al-Khalidi HR, Anstrom K, Dolor RJ, Kosinski A, Krucoff MW, Mudrick DW, Patel MR, Picard MH, Udelson JE, Velazquez EJ, Cooper L, investigators P. PROspective Multicenter Imaging Study for Evaluation of chest pain: Rationale and design of the PROMISE trial. American Heart Journal 2014, 167: 796-803.e1. PMID: 24890527, PMCID: PMC4044617, DOI: 10.1016/j.ahj.2014.03.003.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePROMISE trialAnatomical testingProspective Multicenter Imaging StudyDiagnostic strategiesInitial diagnostic strategyMajor procedural complicationsSubsequent care decisionsComposite of deathPrimary end pointLarge pragmatic trialClinical care teamQuality of lifeDiagnostic testing strategiesMultidetector coronaryChest painSymptomatic patientsUnstable anginaArtery diseaseProcedural complicationsRandomized trialsSymptomatic subjectsClinical effectivenessMyocardial infarctionPragmatic trial
2013
Early Echocardiographic Deformation Analysis for the Prediction of Sudden Cardiac Death and Life-Threatening Arrhythmias After Myocardial Infarction
Ersbøll M, Valeur N, Andersen MJ, Mogensen UM, Vinther M, Svendsen JH, Møller JE, Kisslo J, Velazquez EJ, Hassager C, Søgaard P, Køber L. Early Echocardiographic Deformation Analysis for the Prediction of Sudden Cardiac Death and Life-Threatening Arrhythmias After Myocardial Infarction. JACC Cardiovascular Imaging 2013, 6: 851-860. PMID: 23850252, DOI: 10.1016/j.jcmg.2013.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacDeath, Sudden, CardiacDefibrillators, ImplantableDenmarkEchocardiographyElectric CountershockFemaleHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsPrimary PreventionProportional Hazards ModelsProspective StudiesRisk FactorsStroke VolumeTreatment OutcomeVentricular Function, LeftConceptsGlobal longitudinal strainAcute myocardial infarctionSudden cardiac deathMalignant ventricular arrhythmiasMyocardial infarctionNet reclassification indexVentricular arrhythmiasCardiac deathAddition of GLSMeasurement of GLSSCD/VAsChronic ischemic heart failureNovel echocardiographic parametersPrimary composite endpointPrimary composite outcomeIschemic heart failureEchocardiographic parametersPrimary endpointComposite outcomeHospital dischargeLate complicationsMultivariate adjustmentComposite endpointHeart failureRisk stratificationPrediction of All-Cause Mortality and Heart Failure Admissions From Global Left Ventricular Longitudinal Strain in Patients With Acute Myocardial Infarction and Preserved Left Ventricular Ejection Fraction
Ersbøll M, Valeur N, Mogensen UM, Andersen MJ, Møller JE, Velazquez EJ, Hassager C, Søgaard P, Køber L. Prediction of All-Cause Mortality and Heart Failure Admissions From Global Left Ventricular Longitudinal Strain in Patients With Acute Myocardial Infarction and Preserved Left Ventricular Ejection Fraction. Journal Of The American College Of Cardiology 2013, 61: 2365-2373. PMID: 23563128, DOI: 10.1016/j.jacc.2013.02.061.Peer-Reviewed Original ResearchMeSH KeywordsAgedCause of DeathCohort StudiesConfidence IntervalsEchocardiography, DopplerFemaleHeart FailureHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsPrognosisProportional Hazards ModelsProspective StudiesRisk AssessmentSeverity of Illness IndexStroke VolumeSurvival RateVentricular Dysfunction, LeftConceptsGlobal longitudinal strainHeart failure hospitalizationVentricular ejection fractionAcute myocardial infarctionMyocardial infarctionFailure hospitalizationSecondary endpointsEjection fractionHigh-risk myocardial infarctionVentricular global longitudinal strainLeft ventricular ejection fractionLongitudinal strainHeart failure admissionsPrimary composite endpointCox regression analysisHigh-risk subjectsVentricular longitudinal strainImportant prognostic informationSignificant prognostic valueAssessment of GLSParticular clinical relevanceCardiovascular deathCause mortalityPrimary endpointCardiac deathSystolic Blood Pressure and Cardiovascular Outcomes During Treatment of Hypertension
Weber MA, Bakris GL, Hester A, Weir MR, Hua TA, Zappe D, Dahlof B, Velazquez EJ, Pitt B, Jamerson K. Systolic Blood Pressure and Cardiovascular Outcomes During Treatment of Hypertension. The American Journal Of Medicine 2013, 126: 501-508. PMID: 23541376, DOI: 10.1016/j.amjmed.2013.01.007.Peer-Reviewed Original ResearchConceptsSystolic blood pressureHigh-risk hypertensive patientsPrimary end pointBlood pressure levelsSystolic bloodBlood pressureCardiovascular deathCardiovascular eventsCardiovascular outcomesCoronary eventsEnd pointHypertensive patientsMyocardial infarctionSystolic blood pressure levelsAvoiding Cardiovascular EventsSystolic Hypertension (ACCOMPLISH) trialTotal myocardial infarctionBlood pressure groupMajor cardiovascular eventsMean patient ageNonfatal myocardial infarctionCardiovascular event ratesRenal end pointsLower blood pressureTreatment of hypertension
2012
A Quality Improvement Framework for Equity in Cardiovascular Care: Results of a National Collaborative
Siegel B, Sears V, Bretsch JK, Wilson M, Jones KC, Mead H, Hasnain-Wynia R, Ayala RK, Bhalla R, Cornue CM, Emrich CM, Patel P, Setzer JR, Suitonu J, Velazquez EJ, Eagle KA, Winniford MD. A Quality Improvement Framework for Equity in Cardiovascular Care: Results of a National Collaborative. Journal For Healthcare Quality 2012, 34: 32-43. PMID: 23552200, DOI: 10.1111/j.1945-1474.2011.00196.x.Peer-Reviewed Original ResearchConceptsPatient demographic dataCardiovascular careDemographic dataHeart Failure QualityPatient demographic characteristicsMinority patient populationAcute myocardial infarctionCare of minoritiesEvidence-based practice toolsStandardized collectionEvidence-based measuresComposite measureHispanic patientsAbility of hospitalsMyocardial infarctionPatient populationPatient raceQuality improvement toolsCardiac careMAIN OUTCOMEQuality improvement frameworkCardiac volumesQuality improvement methodsHospitalEthnic disparitiesMechanisms and Predictors of Mitral Regurgitation after High-Risk Myocardial Infarction
Meris A, Amigoni M, Verma A, Thune JJ, Køber L, Velazquez E, McMurray JJ, Pfeffer MA, Califf R, Levine RA, Solomon SD, Investigators V. Mechanisms and Predictors of Mitral Regurgitation after High-Risk Myocardial Infarction. Journal Of The American Society Of Echocardiography 2012, 25: 535-542. PMID: 22305962, PMCID: PMC3501447, DOI: 10.1016/j.echo.2012.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAngiotensin-Converting Enzyme InhibitorsCaptoprilDisease ProgressionEchocardiography, Doppler, ColorElectrocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMitral Valve InsufficiencyMonitoring, PhysiologicMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsProspective StudiesReference ValuesReproducibility of ResultsRisk AssessmentROC CurveSeverity of Illness IndexSex FactorsStatistics, NonparametricStroke VolumeTetrazolesTime FactorsValineValsartanVentricular Dysfunction, LeftVentricular RemodelingConceptsHigh-risk myocardial infarctionBaseline mitral regurgitationMitral regurgitationMyocardial infarctionAtrial sizeIndependent predictorsCoaptation depthProgression of MRMitral valve deformationStructural valve diseaseSevere mitral regurgitationFunctional mitral regurgitationIschemic mitral regurgitationGood-quality echocardiogramsMitral annular areaMitral tentingMR degreeLV dysfunctionTenting areaBaseline characteristicsDiastolic functionHeart failureValve diseaseLV remodelingVentricular remodeling
2011
Circumstances and Outcomes of Sudden Unexpected Death in Patients With High-Risk Myocardial Infarction
Ye S, Grunnert M, Thune JJ, Stephenson KM, Uno H, Finn PV, McMurray JJ, Velazquez EJ, Califf R, Pfeffer MA, Solomon SD. Circumstances and Outcomes of Sudden Unexpected Death in Patients With High-Risk Myocardial Infarction. Circulation 2011, 123: 2674-2680. PMID: 21606398, DOI: 10.1161/circulationaha.110.990655.Peer-Reviewed Original ResearchConceptsHigh-risk myocardial infarctionSudden deathMyocardial infarctionHospital eventsVentricular tachycardia/ventricular fibrillationPrevention of SDSD eventsLong-term mortalityMajority of patientsSudden unexpected deathInitial ECG rhythmCatastrophic complicationUnwitnessed arrestsUnexpected deathVentricular fibrillationTrial trialsPatientsInfarctionECG rhythmDeathPreventionHigher proportionHome eventsArrestSource documentationIncremental value of echocardiographic assessment beyond clinical evaluation for prediction of death and development of heart failure after high-risk myocardial infarction
Verma A, Pfeffer MA, Skali H, Rouleau J, Maggioni A, McMurray JJ, Califf RM, Velazquez EJ, Solomon SD. Incremental value of echocardiographic assessment beyond clinical evaluation for prediction of death and development of heart failure after high-risk myocardial infarction. American Heart Journal 2011, 161: 1156-1162. PMID: 21641363, DOI: 10.1016/j.ahj.2011.03.024.Peer-Reviewed Original ResearchConceptsLV ejection fractionHigh-risk myocardial infarctionOutcome of deathHeart failureEchocardiographic measuresMyocardial infarctionEchocardiographic assessmentEjection fractionPrognostic valueClinical variablesClinical assessmentPredictive valueRight ventricular fractional area changeMultivariable proportional hazards modelsVentricular fractional area changeLeft ventricular ejection fractionMinimal prognostic valueAtrial volume indexIncremental prognostic valuePredictors of deathVentricular mass indexVentricular ejection fractionLeft ventricular functionPrediction of deathImportant prognostic informationResponse to Letter Regarding Article, “Pathogenesis of Sudden Unexpected Death in a Clinical Trial of Patients With Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both”
Pouleur A, Barkoudah E, Uno H, Skali H, Finn P, Zelenkofske S, Belenkov Y, Mareev V, Velazquez E, Rouleau J, Maggioni A, Køber L, Califf R, McMurray J, Pfeffer M, Solomon S. Response to Letter Regarding Article, “Pathogenesis of Sudden Unexpected Death in a Clinical Trial of Patients With Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both”. Circulation 2011, 123: e586-e587. DOI: 10.1161/circulationaha.111.021600.Commentaries, Editorials and LettersPredictors and prognostic impact of recurrent myocardial infarction in patients with left ventricular dysfunction, heart failure, or both following a first myocardial infarction
Thune JJ, Signorovitch JE, Kober L, McMurray JJ, Swedberg K, Rouleau J, Maggioni A, Velazquez E, Califf R, Pfeffer MA, Solomon SD. Predictors and prognostic impact of recurrent myocardial infarction in patients with left ventricular dysfunction, heart failure, or both following a first myocardial infarction. European Journal Of Heart Failure 2011, 13: 148-153. PMID: 21037250, DOI: 10.1093/eurjhf/hfq194.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedCaptoprilCause of DeathConfidence IntervalsDrug Therapy, CombinationFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsPrognosisProportional Hazards ModelsRecurrenceRisk AssessmentSeverity of Illness IndexSex FactorsSurvival AnalysisTetrazolesTime FactorsValineValsartanVentricular Dysfunction, LeftConceptsRecurrent myocardial infarctionFirst myocardial infarctionRisk of deathLeft ventricular dysfunctionMyocardial infarctionVentricular dysfunctionHeart failurePrognostic impactOne-year mortalityGlomerular filtration rateEarly reinfarctionLate reinfarctionTrial cohortUnstable anginaProlong survivalMedian timeMI survivorsFiltration ratePatientsContemporary managementContemporary treatmentInfarctionMortalityReinfarctionDeath