2015
Clinical characteristics and outcomes of patients with and without diabetes in the Surgical Treatment for Ischemic Heart Failure (STICH) trial
MacDonald MR, She L, Doenst T, Binkley PF, Rouleau JL, Tan R, Lee KL, Miller AB, Sopko G, Szalewska D, Waclawiw MA, Dabrowski R, Castelvecchio S, Adlbrecht C, Michler RE, Oh JK, Velazquez EJ, Petrie MC. Clinical characteristics and outcomes of patients with and without diabetes in the Surgical Treatment for Ischemic Heart Failure (STICH) trial. European Journal Of Heart Failure 2015, 17: 725-734. PMID: 26011509, PMCID: PMC4668269, DOI: 10.1002/ejhf.288.Peer-Reviewed Original ResearchConceptsIschemic Heart Failure (STICH) trialHeart Failure TrialDiabetes mellitusMedical therapyHigher LVEFSTICH trialCABG groupPrimary outcomeSurgical treatmentFailure TrialMED groupSmaller left ventricular volumesOptimal medical therapyTriple-vessel CADCoronary artery bypassOutcomes of patientsTriple vessel diseaseLeft ventricular volumeVessel CADArtery bypassCause mortalityClinical characteristicsClinical outcomesVessel diseaseCABGSex differences in clinical characteristics and outcomes after myocardial infarction: insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT)
Lam CS, McEntegart M, Claggett B, Liu J, Skali H, Lewis E, Køber L, Rouleau J, Velazquez E, Califf R, McMurray JJ, Pfeffer M, Solomon S. Sex differences in clinical characteristics and outcomes after myocardial infarction: insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT). European Journal Of Heart Failure 2015, 17: 301-312. PMID: 25655011, DOI: 10.1002/ejhf.238.Peer-Reviewed Original ResearchConceptsAcute Myocardial Infarction trialMyocardial Infarction trialVentricular systolic dysfunctionHeart failureMyocardial infarctionSystolic dysfunctionClinical characteristicsVentricular volumeKillip class III/IVLeft ventricular systolic dysfunctionRisk of HFClass III/IVHigher long-term riskSmaller left ventricular volumesSimilar ejection fractionLong-term mortalityPost-infarction anginaRisk of hospitalizationSubset of patientsNon-fatal outcomesLong-term riskLeft ventricular volumeAssociation of sexMore comorbiditiesCardiovascular death
2012
Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction
Michler RE, Rouleau JL, Al-Khalidi HR, Bonow RO, Pellikka PA, Pohost GM, Holly TA, Oh JK, Dagenais F, Milano C, Wrobel K, Pirk J, Ali IS, Jones RH, Velazquez EJ, Lee KL, Di Donato M, Investigators S. Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2012, 146: 1139-1145.e6. PMID: 23111018, PMCID: PMC3810307, DOI: 10.1016/j.jtcvs.2012.09.007.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexCoronary artery bypassSurgical ventricular reconstructionVentricular reconstructionArtery bypassVolume indexSurvival benefitML/Ischemic heart failureSignificant survival benefitEnd-systolic volumeLeft ventricular volumeSTICH trialPostoperative reductionHeart failureImproved survivalSurgical treatmentClinical benefitVentricular sizeImaging assessmentTreatment groupsVentricular volumePatientsBypassTrial data
2009
Coronary Bypass Surgery with or without Surgical Ventricular Reconstruction
Jones RH, Velazquez EJ, Michler RE, Sopko G, Oh JK, O'Connor CM, Hill JA, Menicanti L, Sadowski Z, Desvigne-Nickens P, Rouleau JL, Lee KL. Coronary Bypass Surgery with or without Surgical Ventricular Reconstruction. New England Journal Of Medicine 2009, 360: 1705-1717. PMID: 19329820, PMCID: PMC3265934, DOI: 10.1056/nejmoa0900559.Peer-Reviewed Original ResearchConceptsSurgical ventricular reconstructionCoronary artery diseaseVentricular reconstructionRate of deathCardiac causesLeft ventricular volumeArtery diseasePrimary outcomeVentricular volumeEnd-systolic volume indexComposite of deathCoronary artery bypassCoronary bypass surgeryLeft ventricular dysfunctionVentricular dysfunctionBypass surgeryCardiac symptomsEjection fractionHeart failureCABGStudy groupPatientsVolume indexHospitalizationAnatomical changes
2007
The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial
Velazquez EJ, Lee KL, O’Connor C, Oh JK, Bonow RO, Pohost GM, Feldman AM, Mark DB, Panza JA, Sopko G, Rouleau JL, Jones RH, Investigators S. The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial. Journal Of Thoracic And Cardiovascular Surgery 2007, 134: 1540-1547.e4. PMID: 18023680, PMCID: PMC3638867, DOI: 10.1016/j.jtcvs.2007.05.069.Peer-Reviewed Original ResearchConceptsIschemic Heart Failure (STICH) trialCoronary artery bypassHeart Failure TrialSurgical ventricular reconstructionArtery bypassMedical therapySurgical treatmentFailure TrialVentricular reconstructionPrimary outcomeNormal left ventricular sizeIntensive medical therapyLeft ventricular dysfunctionVentricular ejection fractionCoronary artery diseaseLeft ventricular sizeLong-term survivalQuality of lifeLeft ventricular volumeCardiac causesSubsequent hospitalizationVentricular dysfunctionArtery diseaseEjection fractionHeart failure