2018
Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction
Pellikka PA, She L, Holly TA, Lin G, Varadarajan P, Pai RG, Bonow RO, Pohost GM, Panza JA, Berman DS, Prior DL, Asch FM, Borges-Neto S, Grayburn P, Al-Khalidi HR, Miszalski-Jamka K, Desvigne-Nickens P, Lee KL, Velazquez EJ, Oh JK. Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction. JAMA Network Open 2018, 1: e181456-e181456. PMID: 30646130, PMCID: PMC6324278, DOI: 10.1001/jamanetworkopen.2018.1456.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionCoronary artery diseaseCardiovascular magnetic resonanceVentricular ejection fractionArtery diseaseCore laboratorySingle photon emissionVentricular dysfunctionEjection fractionBland-Altman plotsLVEF measurementsAssociation of LVEFGated single-photon emissionIschemic heart failureLeft ventricular dysfunctionSubset of patientsOptimal treatment strategyImaging modalitiesMulticenter diagnostic studyCardiac magnetic resonanceInternational multicenter studyLVEF dataMost patientsHeart failureSurgical treatmentSex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization
Piña IL, Zheng Q, She L, Szwed H, Lang IM, Farsky PS, Castelvecchio S, Biernat J, Paraforos A, Kosevic D, Favaloro LE, Nicolau JC, Varadarajan P, Velazquez EJ, Pai RG, Cyrille N, Lee KL, Desvigne-Nickens P. Sex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization. Circulation 2018, 137: 771-780. PMID: 29459462, PMCID: PMC5896331, DOI: 10.1161/circulationaha.117.030526.Peer-Reviewed Original ResearchConceptsIschemic left ventricular dysfunctionLeft ventricular dysfunctionCause mortalityCardiovascular mortalitySTICH trialSurgical deathsVentricular dysfunctionCardiovascular hospitalizationRisk factorsKansas City Cardiomyopathy Questionnaire overall summary scoreHigher New York Heart Association classCardiac Operative Risk Evaluation scoreCoronary artery disease risk factorsNew York Heart Association classHigher body mass indexComposite of deathCoronary artery bypassIschemic heart failureDisease risk factorsPoor prognostic factorVentricular ejection fractionCoronary artery diseaseBody mass indexLong-term outcomesOverall summary score
2017
Impact of Intubation Time on Survival following Coronary Artery Bypass Grafting: Insights from the Surgical Treatment for Ischemic Heart Failure (STICH) Trial
Bouabdallaoui N, Stevens SR, Doenst T, Wrobel K, Bouchard D, Deja MA, Michler RE, Chua YL, Kalil RAK, Selzman CH, Daly RC, Sun B, Djokovic LT, Sopko G, Velazquez EJ, Rouleau JL, Lee KL, Al-Khalidi HR, Investigators F. Impact of Intubation Time on Survival following Coronary Artery Bypass Grafting: Insights from the Surgical Treatment for Ischemic Heart Failure (STICH) Trial. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 1256-1263. PMID: 29422280, PMCID: PMC6517319, DOI: 10.1053/j.jvca.2017.12.038.Peer-Reviewed Original ResearchConceptsCoronary artery bypassIntubation timeArtery bypassSurgical treatmentRisk factorsNew York Heart Association classMultivariable Cox proportional hazards modelsIschemic Heart Failure (STICH) trialPrevious coronary artery bypassMultivariable logistic regression modelCox proportional hazards modelPostoperative intubation timeHeart Failure TrialSystolic volume indexIschemic heart failureMitral valve proceduresIdentification of patientsMortality risk factorsStrong independent predictorProportional hazards modelStrongest predictorLogistic regression modelsPostoperative mortalitySTICH trialPerioperative factorsSudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting
Rao MP, Al-Khatib SM, Pokorney SD, She L, Romanov A, Nicolau JC, Lee KL, Carson P, Selzman CH, Stepinska J, Cleland JG, Tungsubutra W, Desvigne-Nickens PM, Sueta CA, Siepe M, Lang I, Feldman AM, Yii M, Rouleau JL, Velazquez EJ. Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting. Circulation 2017, 135: 1136-1144. PMID: 28154006, PMCID: PMC5516272, DOI: 10.1161/circulationaha.116.026075.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationCoronary Artery BypassDeath, Sudden, CardiacFemaleFollow-Up StudiesHeart FailureHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainPostoperative PeriodProportional Hazards ModelsReceptors, Tumor Necrosis FactorRisk FactorsStroke VolumeVentricular Function, LeftConceptsCoronary artery bypass graft surgerySudden cardiac deathEnd-systolic volume indexB-type natriuretic peptideVentricular ejection fractionSurgical ventricular reconstructionCardiac deathEjection fractionHeart failureNatriuretic peptideVentricular reconstructionPreoperative end-systolic volume indexLow left ventricular ejection fractionIncidence of SCDPredictors of SCDArtery bypass graft surgeryCoronary Artery Bypass GraftingLeft ventricular ejection fractionVolume indexArtery Bypass GraftingBypass graft surgeryIschemic heart failureContemporary clinical trialsBlinded committeeSTICH trial
2016
Markers of Atherosclerosis, Clinical Characteristics, and Treatment Patterns in Heart Failure A Case-Control Study of Middle-Aged Adult Heart Failure Patients in Rural Kenya
Bloomfield GS, DeLong AK, Akwanalo CO, Hogan JW, Carter EJ, Aswa DF, Binanay C, Koech M, Kimaiyo S, Velazquez EJ. Markers of Atherosclerosis, Clinical Characteristics, and Treatment Patterns in Heart Failure A Case-Control Study of Middle-Aged Adult Heart Failure Patients in Rural Kenya. Global Heart 2016, 11: 97-107. PMID: 27102027, PMCID: PMC4843836, DOI: 10.1016/j.gheart.2015.12.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAtherosclerosisBiomarkersCardiomyopathy, DilatedCase-Control StudiesDyslipidemiasEchocardiographyElectrocardiographyFemaleGuideline AdherenceHeart FailureHumansHypertensionKenyaLogistic ModelsMaleMiddle AgedMyocardial IschemiaOdds RatioPractice Guidelines as TopicRisk FactorsRural PopulationConceptsAnkle-brachial indexAtherosclerotic risk factorsIschemic heart failureHeart failureCase-control studyWall motion abnormalitiesRisk factorsMotion abnormalitiesAdult heart failure patientsHuman immunodeficiency virus (HIV) infectionA Case-Control StudyContribution of atherosclerosisImmunodeficiency virus infectionMarker of atherosclerosisHeart failure patientsMultivariable logistic regressionPhysical examination findingsConfidence intervalsRural KenyaIschemic patternLipid testingClinical characteristicsFailure patientsMost patientsExamination findings
2015
Influence of Baseline Characteristics, Operative Conduct, and Postoperative Course on 30-Day Outcomes of Coronary Artery Bypass Grafting Among Patients With Left Ventricular Dysfunction
Wrobel K, Stevens SR, Jones RH, Selzman CH, Lamy A, Beaver TM, Djokovic LT, Wang N, Velazquez EJ, Sopko G, Kron IL, DiMaio JM, Michler RE, Lee KL, Yii M, Leng CY, Zembala M, Rouleau JL, Daly RC, Al-Khalidi HR. Influence of Baseline Characteristics, Operative Conduct, and Postoperative Course on 30-Day Outcomes of Coronary Artery Bypass Grafting Among Patients With Left Ventricular Dysfunction. Circulation 2015, 132: 720-730. PMID: 26304663, PMCID: PMC4551105, DOI: 10.1161/circulationaha.114.014932.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCoronary artery bypassLeft ventricular dysfunctionVentricular dysfunctionArtery diseaseArtery bypassBaseline characteristicsMedical therapyOperative conductSevere left ventricular dysfunctionAtrial fibrillation/flutterSevere coronary artery diseaseLeft ventricular ejection fractionGreater operative riskSignificant preoperative predictorsCardiopulmonary bypass timeHigh-risk patientsIschemic heart failureSerious postoperative complicationsVentricular ejection fractionLeft ventricular sizeSurgical ventricular reconstructionGreater clinical benefitCABG populationSTICH trial
2014
Implication of right ventricular dysfunction on long-term outcome in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting with or without surgical ventricular reconstruction
Kukulski T, She L, Racine N, Gradinac S, Panza JA, Velazquez EJ, Chan K, Petrie MC, Lee KL, Pellikka PA, Romanov A, Biernat J, Rouleau JL, Batlle C, Rogowski J, Ferrazzi P, Zembala M, Oh JK, Investigators S. Implication of right ventricular dysfunction on long-term outcome in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting with or without surgical ventricular reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 1312-1321. PMID: 25451487, PMCID: PMC4385741, DOI: 10.1016/j.jtcvs.2014.09.117.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathiesCoronary Artery BypassCoronary Artery DiseaseFemaleHeart VentriclesHumansKaplan-Meier EstimateMaleMiddle AgedPatient ReadmissionPlastic Surgery ProceduresProportional Hazards ModelsRisk FactorsSeverity of Illness IndexStroke VolumeTime FactorsTreatment OutcomeVentricular Dysfunction, RightVentricular Function, LeftVentricular Function, RightVentricular RemodelingConceptsRight ventricular dysfunctionCoronary artery bypassSurgical ventricular reconstructionSevere right ventricular dysfunctionArtery bypassVentricular dysfunctionRight ventricular functionVentricular reconstructionCause mortalityEnd pointVentricular functionClinical outcomesHigher pulmonary artery systolic pressureAdvanced left ventricular remodelingBaseline right ventricular functionPulmonary artery systolic pressureVentricular ejection fraction 35Ejection fraction 35Larger left ventriclePrimary end pointSecondary end pointsIschemic heart failureLow ejection fractionSevere mitral regurgitationCoronary artery diseaseMyocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: Results of the Surgical Treatment for Ischemic Heart Failure trial
Holly TA, Bonow RO, Arnold JM, Oh JK, Varadarajan P, Pohost GM, Haddad H, Jones RH, Velazquez EJ, Birkenfeld B, Asch FM, Malinowski M, Barretto R, Kalil RA, Berman DS, Sun JL, Lee KL, Panza JA. Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: Results of the Surgical Treatment for Ischemic Heart Failure trial. Journal Of Thoracic And Cardiovascular Surgery 2014, 148: 2677-2684.e1. PMID: 25152476, PMCID: PMC4250319, DOI: 10.1016/j.jtcvs.2014.06.090.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathiesCoronary Artery BypassCoronary Artery DiseaseFemaleHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardiumPlastic Surgery ProceduresPredictive Value of TestsProportional Hazards ModelsSeverity of Illness IndexTime FactorsTissue SurvivalTomography, Emission-Computed, Single-PhotonTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsSurgical ventricular reconstructionCoronary artery bypass graft surgeryIschemic Heart Failure (STICH) trialArtery bypass graft surgeryCoronary artery bypass surgeryBypass graft surgeryHeart Failure TrialArtery bypass surgeryLeft ventricular dysfunctionCoronary artery diseaseType of surgeryCardiac hospitalizationVentricular reconstructionVentricular dysfunctionMyocardial viabilitySurgical treatmentGraft surgeryBypass surgeryArtery diseaseFailure TrialSevere regional left ventricular dysfunctionSevere left ventricular dysfunctionRegional left ventricular dysfunctionOutcomes of patientsIschemic heart failure
2013
Early Echocardiographic Deformation Analysis for the Prediction of Sudden Cardiac Death and Life-Threatening Arrhythmias After Myocardial Infarction
Ersbøll M, Valeur N, Andersen MJ, Mogensen UM, Vinther M, Svendsen JH, Møller JE, Kisslo J, Velazquez EJ, Hassager C, Søgaard P, Køber L. Early Echocardiographic Deformation Analysis for the Prediction of Sudden Cardiac Death and Life-Threatening Arrhythmias After Myocardial Infarction. JACC Cardiovascular Imaging 2013, 6: 851-860. PMID: 23850252, DOI: 10.1016/j.jcmg.2013.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacDeath, Sudden, CardiacDefibrillators, ImplantableDenmarkEchocardiographyElectric CountershockFemaleHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsPrimary PreventionProportional Hazards ModelsProspective StudiesRisk FactorsStroke VolumeTreatment OutcomeVentricular Function, LeftConceptsGlobal longitudinal strainAcute myocardial infarctionSudden cardiac deathMalignant ventricular arrhythmiasMyocardial infarctionNet reclassification indexVentricular arrhythmiasCardiac deathAddition of GLSMeasurement of GLSSCD/VAsChronic ischemic heart failureNovel echocardiographic parametersPrimary composite endpointPrimary composite outcomeIschemic heart failureEchocardiographic parametersPrimary endpointComposite outcomeHospital dischargeLate complicationsMultivariate adjustmentComposite endpointHeart failureRisk stratification
2012
Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction
Michler RE, Rouleau JL, Al-Khalidi HR, Bonow RO, Pellikka PA, Pohost GM, Holly TA, Oh JK, Dagenais F, Milano C, Wrobel K, Pirk J, Ali IS, Jones RH, Velazquez EJ, Lee KL, Di Donato M, Investigators S. Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2012, 146: 1139-1145.e6. PMID: 23111018, PMCID: PMC3810307, DOI: 10.1016/j.jtcvs.2012.09.007.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexCoronary artery bypassSurgical ventricular reconstructionVentricular reconstructionArtery bypassVolume indexSurvival benefitML/Ischemic heart failureSignificant survival benefitEnd-systolic volumeLeft ventricular volumeSTICH trialPostoperative reductionHeart failureImproved survivalSurgical treatmentClinical benefitVentricular sizeImaging assessmentTreatment groupsVentricular volumePatientsBypassTrial dataMyocardial Imaging Should Not Exclude Patients With Ischemic Heart Failure From Coronary Revascularization
Velazquez EJ. Myocardial Imaging Should Not Exclude Patients With Ischemic Heart Failure From Coronary Revascularization. Circulation Cardiovascular Imaging 2012, 5: 271-279. PMID: 22438425, PMCID: PMC3878903, DOI: 10.1161/circimaging.111.964650.Peer-Reviewed Original ResearchCore Lab Analysis of Baseline Echocardiographic Studies in the STICH Trial and Recommendation for Use of Echocardiography in Future Clinical Trials
Oh JK, Pellikka PA, Panza JA, Biernat J, Attisano T, Manahan BG, Wiste HJ, Lin G, Lee K, Miller FA, Stevens S, Sopko G, She L, Velazquez EJ, Investigators S. Core Lab Analysis of Baseline Echocardiographic Studies in the STICH Trial and Recommendation for Use of Echocardiography in Future Clinical Trials. Journal Of The American Society Of Echocardiography 2012, 25: 327-336. PMID: 22227341, PMCID: PMC3310914, DOI: 10.1016/j.echo.2011.12.002.Peer-Reviewed Original ResearchConceptsEjection fractionEffective regurgitant orifice areaRegurgitant orifice areaIschemic cardiomyopathyClinical practiceVentricular end-systolic volume indexPulmonary artery systolic pressureEnd-systolic volume indexLeast moderate mitral regurgitationOrifice areaBaseline echocardiographic examinationBaseline echocardiographic findingsBaseline echocardiographic studyCore lab analysisCoronary artery bypassIschemic heart failureMean ejection fractionCoronary artery diseaseModerate mitral regurgitationUse of echocardiographyMitral inflow velocityEchocardiography core laboratoryFuture clinical trialsCore laboratory analysisMitral regurgitation severity
2009
Quality of life and economic outcomes with surgical ventricular reconstruction in ischemic heart failure: Results from the Surgical Treatment for Ischemic Heart Failure trial
Mark DB, Knight JD, Velazquez EJ, Howlett JG, Spertus JA, Djokovic LT, Harding TM, Rankin GR, Drew LA, Szygula-Jurkiewicz B, Adlbrecht C, Anstrom KJ, Investigators F. Quality of life and economic outcomes with surgical ventricular reconstruction in ischemic heart failure: Results from the Surgical Treatment for Ischemic Heart Failure trial. American Heart Journal 2009, 157: 837-844.e3. PMID: 19376309, PMCID: PMC2694042, DOI: 10.1016/j.ahj.2009.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassFemaleFollow-Up StudiesHealth Care CostsHeart FailureHeart VentriclesHumansMaleMiddle AgedMyocardial IschemiaPlastic Surgery ProceduresQuality of LifeRetrospective StudiesStroke VolumeSurveys and QuestionnairesTreatment OutcomeUnited StatesVentricular Function, LeftConceptsCoronary artery bypass graft surgerySurgical ventricular reconstructionIschemic heart failureQuality of lifeHeart failureVentricular reconstructionQOL measuresIschemic Heart Failure (STICH) trialKansas City Cardiomyopathy QuestionnaireTotal index hospitalization costsArtery bypass graft surgeryLeft ventricular ejection fractionBetter QOLIndex hospitalization costsBypass graft surgeryHeart failure symptomsHeart Failure TrialVentricular ejection fractionLeft ventricular functionHealth care costsTreatment-related differencesGraft surgeryEjection fractionSurgical treatmentVentricular function
2003
Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease?
Bourque JM, Velazquez EJ, Borges-Neto S, Shaw LK, Whellan DJ, O’Connor C. Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease? American Heart Journal 2003, 145: 758-767. PMID: 12766731, DOI: 10.1016/s0002-8703(02)94818-0.Peer-Reviewed Original ResearchMeSH KeywordsCoronary DiseaseFemaleFluorodeoxyglucose F18Heart FailureHumansMaleMyocardial RevascularizationProspective StudiesRadiopharmaceuticalsRetrospective StudiesSurvival RateThallium RadioisotopesTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsSignificant coronary artery diseaseCoronary artery diseaseLong-term mortalityArtery diseaseSurvival rateHeart failureTreatment strategiesImpaired left ventricular functionLong-term mortality ratesIschemic heart failureLeft ventricular functionIntermediate survival ratesNuclear imaging studiesLack of randomizationLower survival rateEjection fractionVentricular functionViable myocardiumReferral biasStudy protocolTreatment allocationLarge cohortPrognostic studiesMortality ratePatients