2023
Electronic health record alerts for management of heart failure with reduced ejection fraction in hospitalized patients: the PROMPT-AHF trial
Ghazi L, Yamamoto Y, Fuery M, O'Connor K, Sen S, Samsky M, Riello R, Dhar R, Huang J, Olufade T, McDermott J, Inzucchi S, Velazquez E, Wilson F, Desai N, Ahmad T. Electronic health record alerts for management of heart failure with reduced ejection fraction in hospitalized patients: the PROMPT-AHF trial. European Heart Journal 2023, 44: 4233-4242. PMID: 37650264, DOI: 10.1093/eurheartj/ehad512.Peer-Reviewed Original ResearchGuideline-directed medical therapyAcute heart failureMineralocorticoid receptor antagonistsHeart failureElectronic health recordsGDMT prescriptionPrimary outcomeEnzyme inhibitors/angiotensin receptor blockers/angiotensin receptor-neprilysin inhibitorsSodium-glucose cotransporter 2 inhibitorsAngiotensin receptor neprilysin inhibitorElectronic health record alertsEvidence-based regimenProviders of patientsReduced ejection fractionCotransporter 2 inhibitorsRelevant patient characteristicsTime of dischargePre-specified criteriaAHF hospitalizationEligible patientsInpatient initiationPatient characteristicsEjection fractionHospitalized patientsMedian age
2022
Pragmatic trial of messaging to providers about treatment of acute heart failure: The PROMPT-AHF trial
Ghazi L, O'Connor K, Yamamoto Y, Fuery M, Sen S, Samsky M, Riello R, Huang J, Olufade T, McDermott J, Inzucchi S, Velazquez E, Wilson F, Desai N, Ahmad T. Pragmatic trial of messaging to providers about treatment of acute heart failure: The PROMPT-AHF trial. American Heart Journal 2022, 257: 111-119. PMID: 36493842, DOI: 10.1016/j.ahj.2022.12.002.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyAcute heart failureHeart failurePragmatic trialElectronic health recordsSubstantial health care costsBest practice advisoryReduced ejection fractionUsual care armHealth recordsTime of dischargeEvidence-based careHealth care costsClinical decision support systemAHF patientsCare armEligible patientsHF hospitalizationInpatient initiationCardiovascular deathMedication classesEjection fractionMedical therapyPrimary outcomePractice advisory
2019
Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012
Kelly JP, Andonian BJ, Patel MJ, Huang Z, Shaw LK, McGarrah RW, Borges-Neto S, Velazquez EJ, Kraus WE. Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012. American Heart Journal 2019, 210: 88-97. PMID: 30743212, PMCID: PMC6441626, DOI: 10.1016/j.ahj.2019.01.001.Peer-Reviewed Original ResearchConceptsExercise treadmill testingCardiorespiratory fitnessTreadmill testingMetabolic equivalentsSingle academic medical centerStandard Bruce protocolMaximal treadmill speedDuke University HospitalAcademic medical centerBaseline comorbiditiesEligible patientsNuclear perfusionBruce protocolClinical outcomesStress echocardiographyUniversity HospitalMedical CenterMedical care environmentClinical practiceRamp protocolMaximal exertionPatientsTreadmill speedPowerful predictorCare environment
2015
Relation of Elevated Heart Rate in Patients With Heart Failure With Reduced Ejection Fraction to One-Year Outcomes and Costs
DeVore AD, Schulte PJ, Mentz RJ, Hardy NC, Kelly JP, Velazquez EJ, Maya JF, Kielhorn A, Patel HK, Reed SD, Hernandez AF. Relation of Elevated Heart Rate in Patients With Heart Failure With Reduced Ejection Fraction to One-Year Outcomes and Costs. The American Journal Of Cardiology 2015, 117: 946-951. PMID: 26805662, PMCID: PMC5429586, DOI: 10.1016/j.amjcard.2015.12.031.Peer-Reviewed Original ResearchConceptsBeats/minReduced ejection fractionElevated heart rateHeart rateHeart failureEjection fractionΒ-blockersMedical costsHospital cost accounting dataLarge tertiary care centerMortality/hospitalizationTertiary care centerOne-year outcomesDirect medical costsNational death recordsRoutine clinical practiceMedian heart rateProportional hazards modelDuke University HospitalHeart rate assessmentElectronic medical recordsCause mortalityEligible patientsMultivariate adjustmentAtrial fibrillationClinical predictors and outcomes of patients with left ventricular thrombus following ST-segment elevation myocardial infarction
Garber AM, Mentz RJ, Al-Khalidi HR, Shaw LK, Fiuzat M, O’Connor C, Velazquez EJ. Clinical predictors and outcomes of patients with left ventricular thrombus following ST-segment elevation myocardial infarction. Journal Of Thrombosis And Thrombolysis 2015, 41: 365-373. PMID: 26202909, DOI: 10.1007/s11239-015-1252-0.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionNon-white raceHF severityBaseline characteristicsClinical predictorsHeart failureIndependent predictorsMyocardial infarctionHeart rateCox proportional hazards regression modelProportional hazards regression modelsLeft ventricular thrombusLong-term mortalityOutcomes of patientsVentricular thrombus formationHazards regression modelsHigher heart rateEligible patientsInitial troponinCause mortalityLAD diseaseSTEMI patientsVentricular thrombusTransthoracic echocardiogram
2014
Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study
Jiang W, Boyle SH, Ortel TL, Samad Z, Velazquez EJ, Harrison RW, Wilson J, Kuhn C, Williams RB, O’Connor C, Becker RC. Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study. American Heart Journal 2014, 169: 496-507.e1. PMID: 25819856, PMCID: PMC4382806, DOI: 10.1016/j.ahj.2014.12.002.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaIschemic heart diseaseSerotonin transporter expressionMyocardial ischemiaPlatelet aggregationPlatelet hyperactivityNormal left ventricular responseStable ischemic heart diseaseStress-induced myocardial ischemiaMental stressTransporter expressionAcute coronary syndromeLeft ventricular responseMental stress testMental stress testingCombination of serotoninEligible patientsCardiovascular eventsCardiovascular prognosisCoronary syndromeVentricular responsePlatelet activityHeart diseaseTreatment studiesIschemia
2013
Prevalence and Clinical Characteristics of Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease
Jiang W, Samad Z, Boyle S, Becker RC, Williams R, Kuhn C, Ortel TL, Rogers J, Kuchibhatla M, O'Connor C, Velazquez EJ. Prevalence and Clinical Characteristics of Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease. Journal Of The American College Of Cardiology 2013, 61: 714-722. PMID: 23410543, PMCID: PMC3913125, DOI: 10.1016/j.jacc.2012.11.037.Peer-Reviewed Original ResearchConceptsMental stress-induced ischemiaStress-induced ischemiaCoronary heart diseaseMental stress-induced myocardial ischemiaStable coronary heart diseaseStress-induced myocardial ischemiaExercise-induced ischemiaHeart diseaseMyocardial ischemiaClinical characteristicsHigh riskMental Stress–Induced Myocardial IschemiaExercise-induced myocardial ischemiaVentricular ejection fraction reductionRegional wall motion abnormalitiesEjection fraction reductionST-segment depressionMental stress testWall motion abnormalitiesUnmarried menEligible patientsPoor prognosisMotion abnormalitiesRisk factorsExercise test