2020
Prevention of cardiovascular disease for historically marginalized racial and ethnic groups living with HIV: A narrative review of the literature
Muiruri C, Longenecker CT, Meissner EG, Okeke NL, Pettit AC, Thomas K, Velazquez E, Bloomfield GS. Prevention of cardiovascular disease for historically marginalized racial and ethnic groups living with HIV: A narrative review of the literature. Progress In Cardiovascular Diseases 2020, 63: 142-148. PMID: 32057785, PMCID: PMC7237291, DOI: 10.1016/j.pcad.2020.02.006.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCardiovascular DiseasesComorbidityHealth Status DisparitiesHealthcare DisparitiesHIV InfectionsHIV Long-Term SurvivorsHumansPreventive Health ServicesPrognosisProtective FactorsRace FactorsRisk AssessmentRisk FactorsSocial Determinants of HealthSocial MarginalizationSocioeconomic FactorsViral LoadVulnerable PopulationsConceptsHuman immunodeficiency virusCardiovascular diseaseComorbid human immunodeficiency virusNarrative reviewSocial determinantsRacial disparitiesCommon social determinantsEthnic disparities persistEthnic groupsCVD morbidityImmunodeficiency virusClinical practiceTranslation of researchClinical researchDisparities persistDiseaseHealthDisparitiesGroupMorbidityReviewPersonsPrevention
2019
Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012
Kelly JP, Andonian BJ, Patel MJ, Huang Z, Shaw LK, McGarrah RW, Borges-Neto S, Velazquez EJ, Kraus WE. Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012. American Heart Journal 2019, 210: 88-97. PMID: 30743212, PMCID: PMC6441626, DOI: 10.1016/j.ahj.2019.01.001.Peer-Reviewed Original ResearchConceptsExercise treadmill testingCardiorespiratory fitnessTreadmill testingMetabolic equivalentsSingle academic medical centerStandard Bruce protocolMaximal treadmill speedDuke University HospitalAcademic medical centerBaseline comorbiditiesEligible patientsNuclear perfusionBruce protocolClinical outcomesStress echocardiographyUniversity HospitalMedical CenterMedical care environmentClinical practiceRamp protocolMaximal exertionPatientsTreadmill speedPowerful predictorCare environment
2018
Right Ventricular Longitudinal Strain Reproducibility Using Vendor-Dependent and Vendor-Independent Software
Il'Giovine ZJ, Mulder H, Chiswell K, Arges K, Tomfohr J, Hashmi A, Velazquez EJ, Kisslo JA, Samad Z, Rajagopal S. Right Ventricular Longitudinal Strain Reproducibility Using Vendor-Dependent and Vendor-Independent Software. Journal Of The American Society Of Echocardiography 2018, 31: 721-732.e5. PMID: 29525250, PMCID: PMC6825401, DOI: 10.1016/j.echo.2018.01.008.Peer-Reviewed Original ResearchConceptsVendor-independent softwarePeak systolic longitudinal strainRight ventricular functionSingle-center studySystolic longitudinal strainMulticenter clinical trialCongenital heart diseaseRepeated-measures analysisRVLS valuesPulmonary hypertensionVentricular functionVendor-specific softwareHeart diseaseClinical trialsEchocardiographic scansClinical practiceLongitudinal strainWidespread variabilityDiseaseGlobal strainDifferent ultrasound scannersEffect of scannerWide variabilityRegional strainPossible interactions
2016
Functional Mitral Regurgitation: Appraising the Evidence Behind Recommended Treatment Strategies
Samad Z, Velazquez EJ. Functional Mitral Regurgitation: Appraising the Evidence Behind Recommended Treatment Strategies. Current Cardiology Reports 2016, 18: 128. PMID: 27796864, DOI: 10.1007/s11886-016-0808-8.Peer-Reviewed Original Research
2015
Use of outcome measures in pulmonary hypertension clinical trials
Parikh KS, Rajagopal S, Arges K, Ahmad T, Sivak J, Kaul P, Shah SH, Tapson V, Velazquez EJ, Douglas PS, Samad Z. Use of outcome measures in pulmonary hypertension clinical trials. American Heart Journal 2015, 170: 419-429.e3. PMID: 26385024, DOI: 10.1016/j.ahj.2015.06.010.Peer-Reviewed Original ResearchConceptsHypertension clinical trialsPulmonary arterial hypertensionPAH trialsClinical practiceInvasive hemodynamicsPrimary endpointClinical trialsOutcome measuresInvasive measuresSurrogate measureDuke University Medical CenterPatient-centered endpointsSecondary outcome measuresClinical treatment trialsMEDLINE/EMBASEUniversity Medical CenterSmall patient populationQuality of lifeContemporary clinical practicePAH therapyPH medicationsArterial hypertensionSerial echocardiographyPatient characteristicsSecondary outcomes
2012
Core Lab Analysis of Baseline Echocardiographic Studies in the STICH Trial and Recommendation for Use of Echocardiography in Future Clinical Trials
Oh JK, Pellikka PA, Panza JA, Biernat J, Attisano T, Manahan BG, Wiste HJ, Lin G, Lee K, Miller FA, Stevens S, Sopko G, She L, Velazquez EJ, Investigators S. Core Lab Analysis of Baseline Echocardiographic Studies in the STICH Trial and Recommendation for Use of Echocardiography in Future Clinical Trials. Journal Of The American Society Of Echocardiography 2012, 25: 327-336. PMID: 22227341, PMCID: PMC3310914, DOI: 10.1016/j.echo.2011.12.002.Peer-Reviewed Original ResearchConceptsEjection fractionEffective regurgitant orifice areaRegurgitant orifice areaIschemic cardiomyopathyClinical practiceVentricular end-systolic volume indexPulmonary artery systolic pressureEnd-systolic volume indexLeast moderate mitral regurgitationOrifice areaBaseline echocardiographic examinationBaseline echocardiographic findingsBaseline echocardiographic studyCore lab analysisCoronary artery bypassIschemic heart failureMean ejection fractionCoronary artery diseaseModerate mitral regurgitationUse of echocardiographyMitral inflow velocityEchocardiography core laboratoryFuture clinical trialsCore laboratory analysisMitral regurgitation severity
2008
Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging.
Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE. Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging. Minerva Cardioangiologica 2008, 56: 227-35. PMID: 18319701.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyTissue Doppler imagingMyocardial perfusion imagingLV dyssynchronyECG-gated SPECT myocardial perfusion imagingPerfusion imagingCardiac resynchronization therapy (CRT) trialsMyocardial strain-rate imagingTomography myocardial perfusion imagingClinical validationAvailable echocardiographic techniquesSPECT myocardial perfusion imagingSevere heart failureVentricular mechanical dyssynchronyPredictors of responseRoutine clinical practiceStrain rate imagingSingle photon emissionEntire left ventricleHeart failureMechanical dyssynchronyResynchronization therapyEchocardiographic techniquesDyssynchronyClinical practice