2022
Surrogate consent for surgery among older adult patients
Miller SM, Nagarkatti N, Ahuja V, Schneider EB, Mohanty S, Rosenthal RA, Kodadek LM. Surrogate consent for surgery among older adult patients. Surgery 2022, 172: 1748-1752. PMID: 36123180, DOI: 10.1016/j.surg.2022.08.015.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overComorbidityFemaleHumansInformed ConsentQuality ImprovementConceptsHalf of patientsCognitive impairmentSurrogate consentHigher comorbidity burdenOlder adult patientsComorbidity burdenPreoperative disabilityAdult patientsOlder patientsFemale patientsSurgical interventionElective proceduresSurgical proceduresHealth characteristicsAmerican CollegeDaily livingOwn consentPatientsOlder adultsImpairmentSurgeryConsentDescriptive analysisFurther researchDiagnosis
2018
Association Between Age and Patient‐Reported Changes in Voice and Swallowing After Thyroidectomy
Sahli Z, Canner J, Najjar O, Schneider E, Prescott J, Russell J, Tufano R, Zeiger M, Mathur A. Association Between Age and Patient‐Reported Changes in Voice and Swallowing After Thyroidectomy. The Laryngoscope 2018, 129: 519-524. PMID: 30194684, PMCID: PMC6344315, DOI: 10.1002/lary.27297.Peer-Reviewed Original ResearchConceptsSwallowing changesSwallowing alterationsRisk factorsIntraoperative recurrent laryngeal nerve monitoringIntact recurrent laryngeal nerveRecurrent laryngeal nerve monitoringPatient-reported voiceGastroesophageal reflux diseaseAdditional prospective studiesLaryngeal nerve monitoringRecurrent laryngeal nervePresence of malignancyImpact of ageInstitutional review boardIntact RLNReflux diseaseRLN injuryTotal thyroidectomyFrailty statusPatient ageConsecutive patientsFrailty indexRetrospective reviewLaryngeal nerveNerve monitoringPrognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors
Strosberg D, Schneider EB, Onesti J, Saunders N, Konda B, Shah M, Dillhoff M, Schmidt CR, Shirley LA. Prognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors. Annals Of Surgical Oncology 2018, 25: 3613-3620. PMID: 30182331, DOI: 10.1245/s10434-018-6741-x.Peer-Reviewed Original ResearchConceptsRepeat transarterial chemoembolizationMetastatic neuroendocrine tumorsTransarterial chemoembolizationPancreastatin levelsNeuroendocrine tumorsOverall survivalPrognostic impactImproved overall survivalProgressive liver diseaseFirst transarterial chemoembolizationWorse overall survivalUseful prognostic indicatorLong-term survivalPg/mLConclusionsFor patientsPost TACECarcinoid syndromeTACE treatmentLiver metastasesPatient demographicsImproved survivalLiver diseasePoor outcomePrognostic indicatorResultsA totalNeutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases
McDermott SM, Saunders ND, Schneider EB, Strosberg D, Onesti J, Dillhoff M, Schmidt CR, Shirley LA. Neutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases. Journal Of Surgical Research 2018, 232: 369-375. PMID: 30463743, DOI: 10.1016/j.jss.2018.06.058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChemoembolization, TherapeuticFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLeukocyte CountLiver NeoplasmsLymphocytesMaleMiddle AgedNeuroendocrine TumorsNeutrophilsPreoperative PeriodPrognosisResponse Evaluation Criteria in Solid TumorsRetrospective StudiesYoung AdultConceptsMedian overall survivalMetastatic neuroendocrine tumorsTransarterial chemoembolizationOverall survivalNeuroendocrine tumorsSingle tertiary medical centerCancer-related treatmentTertiary medical centerNeuroendocrine tumor metastasesPotential treatment strategyElevated NLRLiver metastasesNLR valuesIndependent predictorsBlood workLymphocyte ratioEntire cohortTreatment strategiesPostprocedural careMedical CenterPatientsMultivariate analysisNLRTumor metastasisChemoembolizationConscious status is associated with the likelihood of trauma centre care and mortality in patients with moderate-to-severe traumatic brain injury
AlSulaim H, Haring R, Asemota A, Smart B, Canner J, Ejaz A, Efron D, Velopulos C, Haut E, Schneider E. Conscious status is associated with the likelihood of trauma centre care and mortality in patients with moderate-to-severe traumatic brain injury. Brain Injury 2018, 32: 784-793. PMID: 29561720, DOI: 10.1080/02699052.2018.1451658.Peer-Reviewed Original ResearchConceptsLoss of consciousnessNon-trauma centersTraumatic brain injuryTrauma centerBrain injuryHead/neck Abbreviated Injury Scale scoreNeck Abbreviated Injury Scale scoreLevel I/II trauma centersAbbreviated Injury Scale scoreSevere traumatic brain injuryInjury Scale scoreOdds of mortalityTrauma center careTC treatmentLogistic regression modelsHospital mortalityOlder patientsPatient demographicsPrimary outcomeInjury characteristicsNinth RevisionAIS scoreTBI outcomesPrevention criteriaClinical Modification
2017
One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy
Sahli Z, Najafian A, Kahan S, Schneider E, Zeiger M, Mathur A. One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy. World Journal Of Surgery 2017, 42: 2128-2133. PMID: 29290070, PMCID: PMC5991999, DOI: 10.1007/s00268-017-4444-2.Peer-Reviewed Original ResearchConceptsPostoperative parathyroid hormone levelsPg/mLParathyroid hormone levelsPostoperative PTHPTH levelsBiochemical hypocalcemiaTotal thyroidectomyCalcium supplementationProspective studyHormone levelsAppropriate calcium supplementationDefinitive study designPostoperative biochemical hypocalcemiaAdditional prospective studiesNormal PTH levelsPTH decreaseCompletion thyroidectomyConsecutive patientsSerum calciumLow PTHPTH 1HypocalcemiaIRB approvalThyroidectomyPTHVariability in Gastrostomy Tube Placement for Intracerebral Hemorrhage Patients at US Hospitals
Hwang DY, George BP, Kelly AG, Schneider EB, Sheth KN, Holloway RG. Variability in Gastrostomy Tube Placement for Intracerebral Hemorrhage Patients at US Hospitals. Journal Of Stroke And Cerebrovascular Diseases 2017, 27: 978-987. PMID: 29221969, DOI: 10.1016/j.jstrokecerebrovasdis.2017.11.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCerebral HemorrhageClinical Decision-MakingDatabases, FactualFemaleGastrostomyHealthcare DisparitiesHospitalsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPractice Patterns, Physicians'Process Assessment, Health CareRetrospective StudiesTime FactorsUnited StatesYoung AdultConceptsGastrostomy tube placementTube placementGastrostomy tubeICH patientsIntracerebral hemorrhageUS hospitalsMultilevel multivariable regression modelsHospital random effectsNationwide Inpatient SampleIntracerebral hemorrhage patientsMultivariable regression modelsLocal practice patternsMedian odds ratioICH hospitalizationsHospital factorsHospital covariatesRegression modelsHemorrhage patientsICH admissionsInpatient SampleOdds ratioPlacement ratesPractice patternsMedian increasePatientsRoutine inclusion of long-term functional and patient-reported outcomes into trauma registries
Rios-Diaz A, Herrera-Escobar J, Lilley E, Appelson J, Gabbe B, Brasel K, deRoon-Cassini T, Schneider E, Kasotakis G, Kaafarani H, Velmahos G, Salim A, Haider A. Routine inclusion of long-term functional and patient-reported outcomes into trauma registries. Journal Of Trauma And Acute Care Surgery 2017, 83: 97-104. PMID: 28426563, DOI: 10.1097/ta.0000000000001490.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBenchmarkingBostonFeasibility StudiesFemaleHumansInjury Severity ScoreInterviews as TopicMaleMiddle AgedPatient Reported Outcome MeasuresQuality of LifeRecovery of FunctionRegistriesRetrospective StudiesReturn to WorkStress Disorders, Post-TraumaticSurveys and QuestionnairesWounds and InjuriesConceptsTrauma registryPosttraumatic stress disorderPostinjury experienceTrauma centerSF-12 mental composite scoreSF-12 physical composite scorePatient-reported outcome metricsStress disorderLong-term outcome measuresInstitutional trauma registryInjury Severity ScoreHealth-related qualityPhysical composite scoreHealth care utilizationPatient-reported outcomesMental composite scoreMost trauma centersComposite scoreQuality improvement metricsEligible patientsTrauma patientsCare utilizationSeverity scoreWomen's HospitalTrauma outcomesIntraoperative cholangiography during cholecystectomy among hospitalized medicare beneficiaries with non-neoplastic biliary disease
Lilley EJ, Scott JW, Jiang W, Krasnova A, Raol N, Changoor N, Salim A, Haider AH, Weissman JS, Schneider EB, Cooper Z. Intraoperative cholangiography during cholecystectomy among hospitalized medicare beneficiaries with non-neoplastic biliary disease. The American Journal Of Surgery 2017, 214: 682-686. PMID: 28669532, DOI: 10.1016/j.amjsurg.2017.06.021.Peer-Reviewed Original ResearchConceptsCBD injuryIntraoperative cholangiographyBiliary diseaseInpatient cholecystectomyMedicare beneficiariesCommon bile duct injuryBile duct injuryMultivariable logistic regressionHazard of deathHospitalized Medicare beneficiariesNon-neoplastic indicationsGallbladder obstructionDuct injuryCox regressionRetrospective studyCholecystectomyHigh riskPatientsInjuryLogistic regressionConfirmatory testDiseaseCholangiographySelective useSurvival
2016
Implementation of a Comprehensive Post-Discharge Venous Thromboembolism Prophylaxis Program for Abdominal and Pelvic Surgery Patients
Najjar PA, Madenci AL, Zogg CK, Schneider EB, Dankers CA, Pimentel MT, Chabria AS, Goldberg JE, Sharma G, Piazza G, Bleday R, Orgill DP, Kachalia A. Implementation of a Comprehensive Post-Discharge Venous Thromboembolism Prophylaxis Program for Abdominal and Pelvic Surgery Patients. Journal Of The American College Of Surgeons 2016, 223: 804-813. PMID: 27693288, PMCID: PMC6309555, DOI: 10.1016/j.jamcollsurg.2016.09.010.Peer-Reviewed Original ResearchConceptsPost-intervention cohortPre-intervention cohortInflammatory bowel diseaseVenous thromboembolismProphylaxis programAbdominal surgeryBowel diseasePost-discharge VTE ratesVenous thromboembolism prophylaxis programBedside medication deliveryInpatient venous thromboembolismInstitutional American CollegeSymptomatic venous thromboembolismPrimary end pointMajor abdominal surgeryVTE prevention programSingle-institution retrospectiveSurgeons NSQIP datasetPost-intervention analysisProphylactic anticoagulationVTE prophylaxisVTE ratesVTE eventsNSQIP datasetRisk patientsA comparison of trends in operative approach and postoperative outcomes for colorectal cancer surgery
Addae J, Gani F, Fang S, Wick E, Althumairi A, Efron J, Canner J, Euhus D, Schneider E. A comparison of trends in operative approach and postoperative outcomes for colorectal cancer surgery. Journal Of Surgical Research 2016, 208: 111-120. PMID: 27993198, DOI: 10.1016/j.jss.2016.09.019.Peer-Reviewed Original ResearchConceptsLength of stayShorter LOSColorectal cancer surgerySurgical approachColorectal surgeryPostoperative morbidityPostoperative outcomesCancer surgeryOpen surgeryInvasive surgeryOpen colorectal surgeryInvasive colorectal surgeryTime of surgeryCochrane-Armitage testNationwide Inpatient SampleRobotic colorectal surgeryHigher mean costCRC surgeryPerioperative outcomesPostoperative complicationsInpatient SampleOpen procedureOperative approachMean costSurgeryPredictors of emergency ventral hernia repair: Targets to improve patient access and guide patient selection for elective repair
Wolf LL, Scott JW, Zogg CK, Havens JM, Schneider EB, Smink DS, Salim A, Haider AH. Predictors of emergency ventral hernia repair: Targets to improve patient access and guide patient selection for elective repair. Surgery 2016, 160: 1379-1391. PMID: 27542434, DOI: 10.1016/j.surg.2016.06.027.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overConfidence IntervalsDatabases, FactualElective Surgical ProceduresEmergenciesFemaleFollow-Up StudiesHealth Services AccessibilityHernia, VentralHerniorrhaphyHospital MortalityHumansInsurance CoverageLogistic ModelsMaleMiddle AgedOdds RatioPatient SelectionPredictive Value of TestsQuality ImprovementRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeConceptsVentral hernia repairEmergency ventral hernia repairHospital-level factorsHernia repairIndependent predictorsPatient selectionElective operationsWorse outcomesEmergency repairLonger hospital stayNationwide Inpatient SampleMultivariable logistic regressionUnited States populationRace/ethnicityHospital deathHospital staySecondary outcomesElective repairPrimary outcomePayer statusInpatient SamplePatient outcomesVentral herniasElective careGreater oddsEvaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules
Noureldine S, Najafian A, Han P, Olson M, Genther D, Schneider E, Prescott J, Agrawal N, Mathur A, Zeiger M, Tufano R. Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules. JAMA Otolaryngology - Head & Neck Surgery 2016, 142: 676-82. PMID: 27196108, DOI: 10.1001/jamaoto.2016.0850.Peer-Reviewed Original ResearchConceptsSurgical decision-making processMolecular testingSurgical consultationThyroid nodulesDiagnostic molecular testingEvidence of overtreatmentPertinent treatment optionsSurgical management algorithmRisk of malignancySurgical decision makingSurgical management planRadiological resultsStudy cohortSurgical managementTreatment algorithmProspective studyMean ageTreatment optionsMAIN OUTCOMEPatientsBethesda SystemHistopathology diagnosisControl groupCytopathology classificationHistopathology analysisIntensity of treatment, end-of-life care, and mortality for older patients with severe traumatic brain injury
Lilley E, Williams K, Schneider E, Hammouda K, Salim A, Haider A, Cooper Z. Intensity of treatment, end-of-life care, and mortality for older patients with severe traumatic brain injury. Journal Of Trauma And Acute Care Surgery 2016, 80: 998-1004. PMID: 26953761, DOI: 10.1097/ta.0000000000001028.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryTraumatic brain injuryGeriatric patientsFunctional statusBrain injuryHospital mortality outcomesPatients 65 yearsDays of injuryGoals of careFurther aggressive treatmentSurgery of TraumaIntensity of treatmentHospital mortalityHospital deathLife decision makingAggressive treatmentHospital dischargeIdentifies patientsNeurologic statusNonresponder groupOlder patientsRetrospective reviewMortality outcomesPoor prognosisFunctional impairment30‐Day In‐hospital Trauma Mortality in Four Urban University Hospitals Using an Indian Trauma Registry
Roy N, Gerdin M, Ghosh S, Gupta A, Kumar V, Khajanchi M, Schneider E, Gruen R, Tomson G, von Schreeb J. 30‐Day In‐hospital Trauma Mortality in Four Urban University Hospitals Using an Indian Trauma Registry. World Journal Of Surgery 2016, 40: 1299-1307. PMID: 26911610, DOI: 10.1007/s00268-016-3452-y.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood PressureChildChild, PreschoolDeveloping CountriesFemaleGlasgow Coma ScaleHospital MortalityHospitalizationHospitals, PublicHospitals, UniversityHospitals, UrbanHumansIndiaInfantMaleMiddle AgedProspective StudiesRegistriesTime-to-TreatmentWounds and InjuriesYoung AdultConceptsHospital trauma mortalityTrauma mortalityUniversity HospitalTrauma systemMortality rateAdmission systolic blood pressureHospital mortality rateDays of hospitalizationGlasgow Coma ScoreSystolic blood pressureUrban university hospitalTrauma mortality ratesPublic university hospitalPhysiological scoringCare delaysLate mortalityComa ScoreBlood pressureMedian ageTrauma patientsTrauma registryAdmission vitalsTrauma careTraumatic injuryHigh-income countries“Halo effect” in trauma centers: does it extend to emergent colectomy?
Nagarajan N, Selvarajah S, Gani F, Alshaikh HN, Giuliano K, Zogg CK, Schneider EB, Haider AH. “Halo effect” in trauma centers: does it extend to emergent colectomy? Journal Of Surgical Research 2016, 203: 231-237. PMID: 27125867, DOI: 10.1016/j.jss.2016.01.037.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overColectomyDatabases, FactualDiverticulitis, ColonicEmergenciesFemaleHospital ChargesHospital MortalityHumansLength of StayLinear ModelsLogistic ModelsMaleMiddle AgedPoisson DistributionQuality Assurance, Health CareQuality Indicators, Health CareTrauma CentersTreatment OutcomeUnited StatesYoung AdultConceptsLength of stayNontrauma centersHospital-level characteristicsTrauma centerEmergent colectomyEmergency general surgery conditionsEmergency general surgery proceduresNationwide Emergency Department SampleEmergency surgical interventionOdds of mortalityEmergency Department SampleGeneral surgery proceduresNontrauma conditionsHospital mortalityMedian ageSurgical interventionSurgical conditionsImproved outcomesSex distributionSurgical careMedian chargePatientsSurgery proceduresSurgery conditionsCase mix
2015
Socioeconomic correlates of trauma: An analysis of emergency ward patients in Yaoundé, Cameroon
Kacker S, Bishai D, Mballa G, Monono M, Schneider E, Ngamby K, Hyder A, Juillard C. Socioeconomic correlates of trauma: An analysis of emergency ward patients in Yaoundé, Cameroon. Injury 2015, 47: 658-664. PMID: 26763297, DOI: 10.1016/j.injury.2015.12.011.Peer-Reviewed Original ResearchConceptsLowest SES quintileSocioeconomic statusTrauma centerTreatment outcomesInjury severitySevere injuriesSES quintilesWealth scoreEmergency ward patientsLargest trauma hospitalMajor trauma centreCare-seeking behaviorFuture trauma researchSeverity of injuryRoad traffic injuriesHigher socioeconomic statusEffect of SESProspective registryTrauma patientsWard patientsCentral HospitalInjury characteristicsTrauma hospitalEmergency wardTrauma outcomesDifferences in the Prevalence of Obesity, Smoking and Alcohol in the United States Nationwide Inpatient Sample and the Behavioral Risk Factor Surveillance System
Al Kazzi E, Lau B, Li T, Schneider E, Makary M, Hutfless S. Differences in the Prevalence of Obesity, Smoking and Alcohol in the United States Nationwide Inpatient Sample and the Behavioral Risk Factor Surveillance System. PLOS ONE 2015, 10: e0140165. PMID: 26536469, PMCID: PMC4633065, DOI: 10.1371/journal.pone.0140165.Peer-Reviewed Original ResearchConceptsBehavioral Risk Factor Surveillance SystemNationwide Inpatient SamplePrevalence of obesityUnited States Nationwide Inpatient SampleRisk Factor Surveillance SystemRisk factorsAlcohol abuseTobacco useInpatient SampleAdministrative databasesMedical record codesRisk-adjusted outcomesLarge administrative databaseSurveillance systemTobacco smokingNinth RevisionMedical recordsClinical ModificationLow prevalenceInternational ClassificationOverweightObesityHealthcare reform policiesMorbidityPrevalenceUnited States trends in thrombolysis for older adults with acute ischemic stroke
George B, Asemota A, Dorsey E, Haider A, Smart B, Urrutia V, Schneider E. United States trends in thrombolysis for older adults with acute ischemic stroke. Clinical Neurology And Neurosurgery 2015, 139: 16-23. PMID: 26363362, DOI: 10.1016/j.clineuro.2015.08.031.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleAcute ischemic strokeIschemic strokeOlder adultsStudy periodHospital mortality rateAdult stroke patientsHigh-volume hospitalsLength of stayRate of thrombolysisHigh-volume facilitiesPopulation-based ratesCochran-Armitage testThrombolysis groupVolume hospitalsUrban patientsThrombolysis useIntracerebral hemorrhageStroke patientsPrimary diagnosisInpatient SampleOdds ratioHospitalization dataThrombolysisAge subgroupsIntraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study
Zysk AM, Chen K, Gabrielson E, Tafra L, May Gonzalez EA, Canner JK, Schneider EB, Cittadine AJ, Scott Carney P, Boppart SA, Tsuchiya K, Sawyer K, Jacobs LK. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study. Annals Of Surgical Oncology 2015, 22: 3356-3362. PMID: 26202553, PMCID: PMC4839389, DOI: 10.1245/s10434-015-4665-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularFeasibility StudiesFemaleFollow-Up StudiesHumansIntraoperative PeriodMastectomy, SegmentalMicrosurgeryMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisProspective StudiesReoperationTomography, Optical CoherenceConceptsBreast-conserving surgeryPositive marginsFinal marginsIntraoperative assessmentEarly-stage breast cancerMajority of reoperationsBreast conserving surgeryFinal surgical marginsMethodsForty-six patientsCavity shave marginsJohns Hopkins HospitalReoperation rateMargin statusSitu diseaseSurgical marginsMulticenter studyPostoperative histopathologyNegative marginsResultsA totalPatient outcomesSpecimen marginsBreast cancerMedical CenterMargin specimensBlinded study