2023
Diverticulitis in Older Adults: Is Cognitive Impairment Associated With Outcomes?
Kodadek L, Moore M, Canner J, Schneider E. Diverticulitis in Older Adults: Is Cognitive Impairment Associated With Outcomes? Journal Of Surgical Research 2023, 291: 359-366. PMID: 37506436, DOI: 10.1016/j.jss.2023.06.015.Peer-Reviewed Original ResearchConceptsColonic diverticulitisCognitive impairmentEmergency departmentOlder adultsHospital mortalityOperative interventionInpatient admissionsPrimary diagnosisMultivariable Poisson regression modelsNationwide Emergency Department SamplePrimary payer statusRetrospective cohort studyElixhauser Comorbidity IndexEmergency Department SampleComorbid cognitive impairmentPoisson regression modelsComorbidity indexComplicated diverticulitisCognitive impairment statusCohort studyED encountersPatient ageED carePayer statusRelative riskAn Evaluation of Sex-Based Differences in Surrogate Consent for Older Adults Undergoing Surgical Intervention
Nagarkatti N, Miller S, Ahuja V, Schneider E, Mohanty S, Kodadek L. An Evaluation of Sex-Based Differences in Surrogate Consent for Older Adults Undergoing Surgical Intervention. Journal Of Surgical Research 2023, 288: 246-251. PMID: 37030182, DOI: 10.1016/j.jss.2023.02.041.Peer-Reviewed Original ResearchConceptsPreoperative cognitive impairmentMale patientsCognitive impairmentSurrogate consentSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramPatients age 65Preoperative cognitive statusQuality Improvement ProgramHigh rateSex-based differencesFemale patientsPatient sexSurgical interventionStratified analysisFacets of medicineAge 75American CollegePatientsAge 65Cognitive statusDescriptive studyOlder adultsAge categories
2022
Surrogate consent for surgery among older adult patients
Miller SM, Nagarkatti N, Ahuja V, Schneider EB, Mohanty S, Rosenthal RA, Kodadek LM. Surrogate consent for surgery among older adult patients. Surgery 2022, 172: 1748-1752. PMID: 36123180, DOI: 10.1016/j.surg.2022.08.015.Peer-Reviewed Original ResearchConceptsHalf of patientsCognitive impairmentSurrogate consentHigher comorbidity burdenOlder adult patientsComorbidity burdenPreoperative disabilityAdult patientsOlder patientsFemale patientsSurgical interventionElective proceduresSurgical proceduresHealth characteristicsAmerican CollegeDaily livingOwn consentPatientsOlder adultsImpairmentSurgeryConsentDescriptive analysisFurther researchDiagnosis
2021
Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer
Ying L, Sharma A, Chhoda A, Ruzgar N, Hasan N, Kwak R, Wolfgang CL, Wang TH, Kunstman JW, Salem RR, Wood LD, Iacobuzio-Donahue C, Schneider EB, Farrell JJ, Ahuja N. Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer. Pancreas 2021, 50: 1267-1273. PMID: 34860810, DOI: 10.1097/mpa.0000000000001919.Peer-Reviewed Original Research
2019
Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort
Hawkins R, Mehaffey J, Charles E, Kern J, Schneider E, Tracci M. Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort. Journal Of Vascular Surgery 2019, 70: 1985-1993.e8. PMID: 31761106, DOI: 10.1016/j.jvs.2019.03.060.Peer-Reviewed Original ResearchConceptsDistressed Communities IndexMajor adverse limb eventsAdverse limb eventsInfrainguinal bypassGraft occlusionIndependent predictorsLimb eventsMajor adverse cardiovascular eventsLong-term maleAdverse cardiovascular eventsOperative risk factorsCritical limb ischemiaMore comorbid diseasesCare-related outcomesHealth care-related outcomesPrior amputationHospital mortalityCardiovascular eventsComorbid diseasesLimb ischemiaSurgical outcomesNational cohortVascular diseaseRisk factorsUnivariate analysis
2018
Association Between Age and Patient‐Reported Changes in Voice and Swallowing After Thyroidectomy
Sahli Z, Canner J, Najjar O, Schneider E, Prescott J, Russell J, Tufano R, Zeiger M, Mathur A. Association Between Age and Patient‐Reported Changes in Voice and Swallowing After Thyroidectomy. The Laryngoscope 2018, 129: 519-524. PMID: 30194684, PMCID: PMC6344315, DOI: 10.1002/lary.27297.Peer-Reviewed Original ResearchConceptsSwallowing changesSwallowing alterationsRisk factorsIntraoperative recurrent laryngeal nerve monitoringIntact recurrent laryngeal nerveRecurrent laryngeal nerve monitoringPatient-reported voiceGastroesophageal reflux diseaseAdditional prospective studiesLaryngeal nerve monitoringRecurrent laryngeal nervePresence of malignancyImpact of ageInstitutional review boardIntact RLNReflux diseaseRLN injuryTotal thyroidectomyFrailty statusPatient ageConsecutive patientsFrailty indexRetrospective reviewLaryngeal nerveNerve monitoringPrognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors
Strosberg D, Schneider EB, Onesti J, Saunders N, Konda B, Shah M, Dillhoff M, Schmidt CR, Shirley LA. Prognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors. Annals Of Surgical Oncology 2018, 25: 3613-3620. PMID: 30182331, DOI: 10.1245/s10434-018-6741-x.Peer-Reviewed Original ResearchConceptsRepeat transarterial chemoembolizationMetastatic neuroendocrine tumorsTransarterial chemoembolizationPancreastatin levelsNeuroendocrine tumorsOverall survivalPrognostic impactImproved overall survivalProgressive liver diseaseFirst transarterial chemoembolizationWorse overall survivalUseful prognostic indicatorLong-term survivalPg/mLConclusionsFor patientsPost TACECarcinoid syndromeTACE treatmentLiver metastasesPatient demographicsImproved survivalLiver diseasePoor outcomePrognostic indicatorResultsA totalNeutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases
McDermott SM, Saunders ND, Schneider EB, Strosberg D, Onesti J, Dillhoff M, Schmidt CR, Shirley LA. Neutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases. Journal Of Surgical Research 2018, 232: 369-375. PMID: 30463743, DOI: 10.1016/j.jss.2018.06.058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChemoembolization, TherapeuticFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLeukocyte CountLiver NeoplasmsLymphocytesMaleMiddle AgedNeuroendocrine TumorsNeutrophilsPreoperative PeriodPrognosisResponse Evaluation Criteria in Solid TumorsRetrospective StudiesYoung AdultConceptsMedian overall survivalMetastatic neuroendocrine tumorsTransarterial chemoembolizationOverall survivalNeuroendocrine tumorsSingle tertiary medical centerCancer-related treatmentTertiary medical centerNeuroendocrine tumor metastasesPotential treatment strategyElevated NLRLiver metastasesNLR valuesIndependent predictorsBlood workLymphocyte ratioEntire cohortTreatment strategiesPostprocedural careMedical CenterPatientsMultivariate analysisNLRTumor metastasisChemoembolizationManagement outcomes of diverticulitis and colitis in patients with active cancer
Horwood C, Wisler J, Byrd S, Woodling K, Schneider E, Rushing A. Management outcomes of diverticulitis and colitis in patients with active cancer. Surgery 2018, 164: 350-353. PMID: 29801733, DOI: 10.1016/j.surg.2018.03.010.Peer-Reviewed Original ResearchConceptsActive cancer diagnosisColonic emergenciesActive cancerNonoperative managementIntensive care unit admissionEmergent general surgeryCare unit admissionPreoperative risk factorsCancer diagnosisNon-operative managementCancer patient populationIntensive care unitNonoperative groupNonoperative patientsUnit admissionPostoperative complicationsCare unitColonic pathologyOperative groupSurgery consultOperative managementPatient populationCancer DatabaseRisk factorsGeneral surgeryBilateral mastectomies: can a co-surgeon technique offer improvements over the single-surgeon method?
Mallory MA, Tarabanis C, Schneider E, Nimbkar S, Golshan M. Bilateral mastectomies: can a co-surgeon technique offer improvements over the single-surgeon method? Breast Cancer Research And Treatment 2018, 170: 641-646. PMID: 29687179, PMCID: PMC6026038, DOI: 10.1007/s10549-018-4794-y.Peer-Reviewed Original ResearchConceptsSingle surgeon's techniqueTotal breast weightAxillary procedureComplication rateOperative timeBreast weightChi-square testSS cohortTBW patientsMultivariate linear regression modelPatient ageUnilateral mastectomyBRCA statusBM casesAverage durationComplicationsDemographic characteristicsMastectomyPatientsT-testLinear regression modelsCohortRegression modelsBM proceduresBMConscious status is associated with the likelihood of trauma centre care and mortality in patients with moderate-to-severe traumatic brain injury
AlSulaim H, Haring R, Asemota A, Smart B, Canner J, Ejaz A, Efron D, Velopulos C, Haut E, Schneider E. Conscious status is associated with the likelihood of trauma centre care and mortality in patients with moderate-to-severe traumatic brain injury. Brain Injury 2018, 32: 784-793. PMID: 29561720, DOI: 10.1080/02699052.2018.1451658.Peer-Reviewed Original ResearchConceptsLoss of consciousnessNon-trauma centersTraumatic brain injuryTrauma centerBrain injuryHead/neck Abbreviated Injury Scale scoreNeck Abbreviated Injury Scale scoreLevel I/II trauma centersAbbreviated Injury Scale scoreSevere traumatic brain injuryInjury Scale scoreOdds of mortalityTrauma center careTC treatmentLogistic regression modelsHospital mortalityOlder patientsPatient demographicsPrimary outcomeInjury characteristicsNinth RevisionAIS scoreTBI outcomesPrevention criteriaClinical Modification
2017
One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy
Sahli Z, Najafian A, Kahan S, Schneider E, Zeiger M, Mathur A. One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy. World Journal Of Surgery 2017, 42: 2128-2133. PMID: 29290070, PMCID: PMC5991999, DOI: 10.1007/s00268-017-4444-2.Peer-Reviewed Original ResearchConceptsPostoperative parathyroid hormone levelsPg/mLParathyroid hormone levelsPostoperative PTHPTH levelsBiochemical hypocalcemiaTotal thyroidectomyCalcium supplementationProspective studyHormone levelsAppropriate calcium supplementationDefinitive study designPostoperative biochemical hypocalcemiaAdditional prospective studiesNormal PTH levelsPTH decreaseCompletion thyroidectomyConsecutive patientsSerum calciumLow PTHPTH 1HypocalcemiaIRB approvalThyroidectomyPTHFinancial Impact of Acute Kidney Injury After Cardiac Operations in the United States
Alshaikh H, Katz N, Gani F, Nagarajan N, Canner J, Kacker S, Najjar P, Higgins R, Schneider E. Financial Impact of Acute Kidney Injury After Cardiac Operations in the United States. The Annals Of Thoracic Surgery 2017, 105: 469-475. PMID: 29275828, DOI: 10.1016/j.athoracsur.2017.10.053.Peer-Reviewed Original ResearchConceptsAcute kidney injuryIndex hospitalization costsTotal index hospitalization costsIndex hospital costsCardiac operationsHospitalization costsKidney injuryDevelopment of AKISubstantial health care cost savingsClinical Modification diagnosis codesHealth care cost savingsMajor cardiac operationsCoronary artery bypassChronic renal failureNationwide Inpatient SampleMajor cardiac proceduresLong-term treatmentArtery bypassRenal failureValve replacementReplacement patientsAvoidable complicationsCardiac proceduresPatient morbidityDiagnosis codesVariability in Gastrostomy Tube Placement for Intracerebral Hemorrhage Patients at US Hospitals
Hwang DY, George BP, Kelly AG, Schneider EB, Sheth KN, Holloway RG. Variability in Gastrostomy Tube Placement for Intracerebral Hemorrhage Patients at US Hospitals. Journal Of Stroke And Cerebrovascular Diseases 2017, 27: 978-987. PMID: 29221969, DOI: 10.1016/j.jstrokecerebrovasdis.2017.11.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCerebral HemorrhageClinical Decision-MakingDatabases, FactualFemaleGastrostomyHealthcare DisparitiesHospitalsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPractice Patterns, Physicians'Process Assessment, Health CareRetrospective StudiesTime FactorsUnited StatesYoung AdultConceptsGastrostomy tube placementTube placementGastrostomy tubeICH patientsIntracerebral hemorrhageUS hospitalsMultilevel multivariable regression modelsHospital random effectsNationwide Inpatient SampleIntracerebral hemorrhage patientsMultivariable regression modelsLocal practice patternsMedian odds ratioICH hospitalizationsHospital factorsHospital covariatesRegression modelsHemorrhage patientsICH admissionsInpatient SampleOdds ratioPlacement ratesPractice patternsMedian increasePatientsPatient-Provider Communication and Health Outcomes Among Individuals with Hepato-Pancreato-Biliary Disease in the USA
Chen Q, Beal E, Schneider E, Okunrintemi V, Zhang X, Pawlik T. Patient-Provider Communication and Health Outcomes Among Individuals with Hepato-Pancreato-Biliary Disease in the USA. Journal Of Gastrointestinal Surgery 2017, 22: 624-632. PMID: 29159756, DOI: 10.1007/s11605-017-3610-z.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiliary Tract DiseasesCommunicationDelivery of Health CareDemographyDigestive System DiseasesFemaleHealth ResourcesHumansLiver DiseasesMaleMiddle AgedPancreatic DiseasesPatient Care TeamPatient Reported Outcome MeasuresPatient SatisfactionPhysician-Patient RelationsSelf ReportSurveys and QuestionnairesUnited StatesYoung AdultConceptsMedical Expenditure Panel Survey cohortHealth outcomesPatient-reported health outcomesSelf-reported patient satisfactionPatient-specific demographicsHealthcare resource utilizationPoor mental statusPatient-provider communicationHigher emergency departmentMental health componentOverall healthcare expendituresPatient-provider interactionsHPB patientsStatin useBiliary diseaseEmergency departmentPatient satisfactionCare measuresHPB diseasesMental statusProvider communicationBiliary diagnosesHepato-PancreatoRepresentative cohortPatientsImpact of the insurance type of head and neck cancer patients on their hospitalization utilization patterns
Gupta A, Sonis S, Schneider E, Villa A. Impact of the insurance type of head and neck cancer patients on their hospitalization utilization patterns. Cancer 2017, 124: 760-768. PMID: 29112234, DOI: 10.1002/cncr.31095.Peer-Reviewed Original ResearchConceptsHNC patientsHospital typeUninsured patientsInsurance typeMortality riskInsurance-related disparitiesInferior survival outcomesNationwide Inpatient SampleNeck cancer patientsLogistic regression modelsOptimum treatment outcomesMultinomial logistic regression modelsPatient agePoor outcomeSurvival outcomesPrimary exposureCancer patientsInpatient SampleHNC outcomesInpatient careTreatment outcomesHospital settingProvider typePatientsGovernment hospitalsRoutine inclusion of long-term functional and patient-reported outcomes into trauma registries
Rios-Diaz A, Herrera-Escobar J, Lilley E, Appelson J, Gabbe B, Brasel K, deRoon-Cassini T, Schneider E, Kasotakis G, Kaafarani H, Velmahos G, Salim A, Haider A. Routine inclusion of long-term functional and patient-reported outcomes into trauma registries. Journal Of Trauma And Acute Care Surgery 2017, 83: 97-104. PMID: 28426563, DOI: 10.1097/ta.0000000000001490.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBenchmarkingBostonFeasibility StudiesFemaleHumansInjury Severity ScoreInterviews as TopicMaleMiddle AgedPatient Reported Outcome MeasuresQuality of LifeRecovery of FunctionRegistriesRetrospective StudiesReturn to WorkStress Disorders, Post-TraumaticSurveys and QuestionnairesWounds and InjuriesConceptsTrauma registryPosttraumatic stress disorderPostinjury experienceTrauma centerSF-12 mental composite scoreSF-12 physical composite scorePatient-reported outcome metricsStress disorderLong-term outcome measuresInstitutional trauma registryInjury Severity ScoreHealth-related qualityPhysical composite scoreHealth care utilizationPatient-reported outcomesMental composite scoreMost trauma centersComposite scoreQuality improvement metricsEligible patientsTrauma patientsCare utilizationSeverity scoreWomen's HospitalTrauma outcomesIntraoperative cholangiography during cholecystectomy among hospitalized medicare beneficiaries with non-neoplastic biliary disease
Lilley EJ, Scott JW, Jiang W, Krasnova A, Raol N, Changoor N, Salim A, Haider AH, Weissman JS, Schneider EB, Cooper Z. Intraoperative cholangiography during cholecystectomy among hospitalized medicare beneficiaries with non-neoplastic biliary disease. The American Journal Of Surgery 2017, 214: 682-686. PMID: 28669532, DOI: 10.1016/j.amjsurg.2017.06.021.Peer-Reviewed Original ResearchConceptsCBD injuryIntraoperative cholangiographyBiliary diseaseInpatient cholecystectomyMedicare beneficiariesCommon bile duct injuryBile duct injuryMultivariable logistic regressionHazard of deathHospitalized Medicare beneficiariesNon-neoplastic indicationsGallbladder obstructionDuct injuryCox regressionRetrospective studyCholecystectomyHigh riskPatientsInjuryLogistic regressionConfirmatory testDiseaseCholangiographySelective useSurvivalA Novel Risk Score to Predict the Need for Nutrition Support After Cardiac Surgery
Ohkuma R, Crawford T, Brown P, Grimm J, Magruder J, Kilic A, Suarez-Pierre A, Snyder S, Wood J, Schneider E, Sussman M, Whitman G. A Novel Risk Score to Predict the Need for Nutrition Support After Cardiac Surgery. The Annals Of Thoracic Surgery 2017, 104: 1306-1312. PMID: 28625392, DOI: 10.1016/j.athoracsur.2017.03.013.Peer-Reviewed Original ResearchConceptsPostoperative nutrition supportNutrition supportCardiac surgeryNS scoresAdult cardiac surgery patientsMultivariable logistic regression modelingEarly postoperative nutritionMalnutrition-related morbidityCardiac surgery patientsNovel risk scoreRelative odds ratioLogistic regression modelingTiming of initiationPostoperative nutritionSurgery patientsDerivation cohortIndependent predictorsPredictive screening toolMultivariable analysisValidation cohortC-statisticOdds ratioHigh riskRisk scorePatientsImpact of Surgeon Specialty on Perioperative Outcomes of Surgery for Benign Esophageal Diseases: A NSQIP Analysis
Khoshhal Z, Canner J, Schneider E, Stem M, Haut E, Schlottmann F, Barbetta A, Mungo B, Lidor A, Molena D. Impact of Surgeon Specialty on Perioperative Outcomes of Surgery for Benign Esophageal Diseases: A NSQIP Analysis. Journal Of Laparoendoscopic & Advanced Surgical Techniques 2017, 27: 924-930. PMID: 28594583, PMCID: PMC5749579, DOI: 10.1089/lap.2017.0083.Peer-Reviewed Original ResearchConceptsBenign esophageal diseaseGeneral surgeonsHeller esophagomyotomyEsophageal diseaseGS groupPerioperative outcomesHome dischargePEH repairSurgeon specialtyBetter outcomesMore home dischargesMultivariable logistic regressionParaesophageal hernia repairLower mortality rateNSQIP AnalysisHospital lengthOverall morbidityDischarge destinationGastric fundoplicationReadmission ratesLaparoscopic approachLow comorbidityShorter LOSACS-NSQIPBenign disease