2022
Surrogate consent for surgery among older adult patients
Miller SM, Nagarkatti N, Ahuja V, Schneider EB, Mohanty S, Rosenthal RA, Kodadek LM. Surrogate consent for surgery among older adult patients. Surgery 2022, 172: 1748-1752. PMID: 36123180, DOI: 10.1016/j.surg.2022.08.015.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overComorbidityFemaleHumansInformed ConsentQuality ImprovementConceptsHalf of patientsCognitive impairmentSurrogate consentHigher comorbidity burdenOlder adult patientsComorbidity burdenPreoperative disabilityAdult patientsOlder patientsFemale patientsSurgical interventionElective proceduresSurgical proceduresHealth characteristicsAmerican CollegeDaily livingOwn consentPatientsOlder adultsImpairmentSurgeryConsentDescriptive analysisFurther researchDiagnosis
2017
Obesity and its implications for morbidity and mortality after cholecystectomy: A matched NSQIP analysis
Augustin T, Moslim M, Brethauer S, Aminian A, Kroh M, Schneider E, Walsh R. Obesity and its implications for morbidity and mortality after cholecystectomy: A matched NSQIP analysis. The American Journal Of Surgery 2017, 213: 539-543. PMID: 28237044, DOI: 10.1016/j.amjsurg.2016.11.037.Peer-Reviewed Original ResearchConceptsAcute cholecystitisClavien 4 complicationsSO patientsNSQIP AnalysisSuper obesityOpen surgeryNon-obese patientsObese patientsSerious morbidityLaparoscopic surgeryCholecystectomyPatientsSurgeryMorbidityComplicationsObesityChronicMortalityAggressive recommendationsRiskCholecystitisComorbidities
2016
Frailty predicts risk of life-threatening complications and mortality after pancreatic resections
Augustin T, Burstein M, Schneider E, Morris-Stiff G, Wey J, Chalikonda S, Walsh R. Frailty predicts risk of life-threatening complications and mortality after pancreatic resections. Surgery 2016, 160: 987-996. PMID: 27545992, DOI: 10.1016/j.surg.2016.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedCause of DeathComorbidityDatabases, FactualFemaleFrail ElderlyHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisPancreatectomyPancreatic NeoplasmsPancreaticoduodenectomyPostoperative ComplicationsPredictive Value of TestsRetrospective StudiesRisk AssessmentROC CurveSeverity of Illness IndexSex FactorsSurvival AnalysisTreatment OutcomeConceptsNational Surgical Quality Improvement ProjectSurgical Quality Improvement ProjectGrade 4 complicationsFrailty indexQuality improvement projectGreater body mass indexDistal pancreatectomy patientsModified Frailty IndexOutcomes of pancreatoduodenectomyLow serum albuminLife-threatening complicationsPre-operative optimizationEffect of frailtySelection of patientsBody mass indexDegree of frailtyGreater weight lossImprovement projectIntermediate frailtyNonfrail patientsConsideration of frailtyDistal pancreatectomyFrail patientsOperative riskPancreatectomy patientsOutcomes of abdominoperineal resection for management of anal cancer in HIV-positive patients: a national case review
Leeds IL, Alturki H, Canner JK, Schneider EB, Efron JE, Wick EC, Gearhart SL, Safar B, Fang SH. Outcomes of abdominoperineal resection for management of anal cancer in HIV-positive patients: a national case review. World Journal Of Surgical Oncology 2016, 14: 208. PMID: 27495294, PMCID: PMC4974747, DOI: 10.1186/s12957-016-0970-x.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAdultAge FactorsAgedAnus NeoplasmsCarcinoma, Squamous CellComorbidityFemaleFollow-Up StudiesHealth Status DisparitiesHIV InfectionsHospital MortalityHumansIncidenceLength of StayMaleMiddle AgedNeoplasm Recurrence, LocalPerineumPostoperative ComplicationsRetrospective StudiesRisk FactorsSalvage TherapyTreatment OutcomeConceptsHIV-positive patientsLength of stayHIV-negative patientsAnal cancerNational Inpatient SampleAbdominoperineal resectionHospitalization costsHIV infectionAnal squamous cell cancerAnal squamous cell carcinomaUtilization Project National Inpatient SampleGreater hospitalization costsWorse postoperative recoveryHIV-positive groupMethodsA retrospective reviewAnal cancer patientsSquamous cell cancerHuman immunodeficiency virusMultivariable logistic regressionSquamous cell carcinomaHospital mortalityHospital stayPerioperative complicationsPostoperative hemorrhagePostoperative outcomes
2015
National estimates of predictors of outcomes for emergency general surgery
Shah AA, Haider AH, Zogg CK, Schwartz DA, Haut ER, Zafar SN, Schneider EB, Velopulos CG, Shafi S, Zafar H, Efron DT. National estimates of predictors of outcomes for emergency general surgery. Journal Of Trauma And Acute Care Surgery 2015, 78: 482-491. PMID: 25710417, DOI: 10.1097/ta.0000000000000555.Peer-Reviewed Original ResearchConceptsEmergency general surgeryEGS patientsMajor complicationsGeneral surgeryMultivariate logistic regression analysisOverall complication ratePredictors of mortalityClinical Modification codesOverall mortality rateNationwide Inpatient SampleSeparate multivariate logistic regression analysesSurgery of TraumaDRG International ClassificationLogistic regression analysisHighest income quartileHospital complicationsHospital mortalityComplication ratePatient demographicsSurgical complicationsIndependent predictorsPrimary outcomeEGS conditionsMean ageInpatient SampleOutcomes after emergency general surgery at teaching versus nonteaching hospitals
Zafar S, Shah A, Hashmi Z, Efron D, Haut E, Schneider E, Schwartz D, Velopulos C, Cornwell E, Haider A. Outcomes after emergency general surgery at teaching versus nonteaching hospitals. Journal Of Trauma And Acute Care Surgery 2015, 78: 69-77. PMID: 25539205, DOI: 10.1097/ta.0000000000000493.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultAgedAged, 80 and overComorbidityEmergency TreatmentFemaleGeneral SurgeryHospital CostsHospital MortalityHospitals, TeachingHumansLength of StayMaleMiddle AgedOutcome and Process Assessment, Health CarePostoperative ComplicationsPropensity ScoreQuality of Health CareRetrospective StudiesSeverity of Illness IndexUnited StatesConceptsLength of stayHospital costsMajor complicationsQuality of careTeaching hospitalEGS conditionsNonteaching hospitalsEmergency general surgery conditionsEffect estimatesEmergency general surgeryHospital-level factorsMajority of patientsNationwide Inpatient SampleHigher hospital costsSurgery of TraumaEmergency surgical conditionsStandardized differenceMultivariate regression analysisEGS volumeHospital mortalityOperative managementInpatient SampleSurgical conditionsWorse outcomesGeneral surgery
2014
Encephalitis Hospitalization Rates and Inpatient Mortality in the United States, 2000-2010
George B, Schneider E, Venkatesan A. Encephalitis Hospitalization Rates and Inpatient Mortality in the United States, 2000-2010. PLOS ONE 2014, 9: e104169. PMID: 25192177, PMCID: PMC4156306, DOI: 10.1371/journal.pone.0104169.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleHospitalization ratesEncephalitis hospitalizationsInpatient mortalitySpecified causeComorbid HIV/AIDSAcute phase outcomesComorbid HIV infectionDiagnosis of encephalitisOdds of mortalityRetrospective observational studyCommon infectious agentsAcute care hospitalsYears of ageHerpes simplex virusHIV/AIDSAutoimmune conditionsCare hospitalHIV infectionWest Nile virusCause-specific ratesEncephalitis patientsViral causeAdjusted oddsInpatient SampleCholecystectomy and Wound Complications: Smoking Worsens Risk
Selvarajah S, Ahmed A, Schneider E, Canner J, Pawlik T, Abularrage C, Hui X, Schwartz D, Hisam B, Haider A. Cholecystectomy and Wound Complications: Smoking Worsens Risk. Journal Of Surgical Research 2014, 192: 41-49. PMID: 25015752, DOI: 10.1016/j.jss.2014.06.014.Peer-Reviewed Original ResearchConceptsWound complicationsActive smokersLaparoscopic cholecystectomyPostoperative lengthSurgical approachNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseCurrent Procedural Terminology codesImprovement Program databaseWound complication rateAverage postoperative lengthBenign gallbladder diseaseProcedural Terminology codesPreoperative smokingClinical characteristicsOpen cholecystectomyComplication rateSmoking statusGallbladder diseaseProgram databaseCholecystectomyTerminology codesComplicationsSmokersPatients
2013
Influence of Patient, Physician, and Hospital Factors on 30-Day Readmission Following Pancreatoduodenectomy in the United States
Hyder O, Dodson R, Nathan H, Schneider E, Weiss M, Cameron J, Choti M, Makary M, Hirose K, Wolfgang C, Herman J, Pawlik T. Influence of Patient, Physician, and Hospital Factors on 30-Day Readmission Following Pancreatoduodenectomy in the United States. JAMA Surgery 2013, 148: 1095-1102. PMID: 24108580, PMCID: PMC3983984, DOI: 10.1001/jamasurg.2013.2509.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAttitude of Health PersonnelCohort StudiesComorbidityCross InfectionFemaleHealth Care SurveysHospital MortalityHumansLength of StayMaleMedicareOutcome Assessment, Health CarePancreatic NeoplasmsPancreaticoduodenectomyPatient ReadmissionPostoperative ComplicationsPractice Patterns, Physicians'Retrospective StudiesRisk FactorsSEER ProgramSurvival RateTime FactorsUnited StatesWorkloadConceptsPancreatoduodenectomy proceduresMedical comorbiditiesHospital factorsSurgeon volumeMedicare dataPopulation-based cancer registry dataPreoperative medical comorbiditiesRetrospective cohort studyDays of dischargeHospital-level factorsLow-volume hospitalsPatient-related factorsChance of readmissionLength of stayInfluence of patientCancer registry dataPancreatoduodenectomy patientsHospital morbidityCohort studyHospital volumeHospital readmissionMedian agePhysician factorsDistinct hospitalsPatient levelIncreased complications after appendectomy in patients with cerebral palsy: Are special needs patients at risk for disparities in outcomes?
Dhiman N, Chi A, Pawlik T, Efron D, Haut E, Schneider E, Hashmi Z, Scott V, Hui X, Ali M, Haider A. Increased complications after appendectomy in patients with cerebral palsy: Are special needs patients at risk for disparities in outcomes? Surgery 2013, 154: 479-485. PMID: 23972654, DOI: 10.1016/j.surg.2013.05.038.Peer-Reviewed Original ResearchConceptsCerebral palsyHospital stayPostoperative complicationsLaparoscopic appendectomyAcute respiratory distress syndromeNon-CP patientsOperation-related infectionOdds of complicationsRespiratory distress syndromeUrinary tract infectionNationwide Inpatient SampleHospital discharge dataSpecial needs patientsCommon operative procedureMultiple logistic regressionRecognition of symptomsCP patientsInpatient mortalityPostoperative outcomesTract infectionsDistress syndromeOrgan failureAdjusted analysisPatient assessmentInpatient SampleIncreased risk of pneumonia among ventilated patients with traumatic brain injury: every day counts!
Hui X, Haider A, Hashmi Z, Rushing A, Dhiman N, Scott V, Selvarajah S, Haut E, Efron D, Schneider E. Increased risk of pneumonia among ventilated patients with traumatic brain injury: every day counts! Journal Of Surgical Research 2013, 184: 438-443. PMID: 23816243, DOI: 10.1016/j.jss.2013.05.072.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryRisk of pneumoniaMechanical ventilationCause pneumoniaAIS scoreBrain injuryGlasgow Coma Scale motor scoreNational Trauma Data Bank 2007Days of MVICDMAP-90 softwareDevelopment of pneumoniaInjury Scale scoreScale motor scoreRisk of VAPApproximate relative riskVentilator independenceComorbidity scoreHospital lengthNeurologic impairmentMotor scoresVentilated patientsInjury factorsInsurance statusInjury typePneumonia casesHispanic ethnicity is associated with increased costs after carotid endarterectomy and carotid stenting in the United States
Propper B, Black J, Schneider E, Lum Y, Malas M, Arnold M, Abularrage C. Hispanic ethnicity is associated with increased costs after carotid endarterectomy and carotid stenting in the United States. Journal Of Surgical Research 2013, 184: 644-650. PMID: 23582759, DOI: 10.1016/j.jss.2013.03.057.Peer-Reviewed Original ResearchConceptsCarotid artery stentingTotal hospital chargesCarotid endarterectomyHospital chargesHispanic ethnicityBlack patientsUnivariate analysisOperative volumeCost of CEAHospital operative volumeSurgeon operative volumesLow-volume hospitalsNationwide Inpatient SampleCarotid artery stenosisICD-9 codesLow-volume surgeonsHigh-risk statusOnly Hispanic ethnicityPostoperative complicationsCarotid revascularizationSymptomatic statusArtery stentingPrimary outcomeSymptomatic presentationArtery stenosisRacial and ethnic disparities in the treatment of unruptured thoracoabdominal aortic aneurysms in the United States
Arnaoutakis D, Propper B, Black J, Schneider E, Lum Y, Freischlag J, Perler B, Abularrage C. Racial and ethnic disparities in the treatment of unruptured thoracoabdominal aortic aneurysms in the United States. Journal Of Surgical Research 2013, 184: 651-657. PMID: 23545407, DOI: 10.1016/j.jss.2013.03.018.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic Aneurysm, AbdominalAortic Aneurysm, ThoracicBlack or African AmericanComorbidityEthnicityFemaleHealthcare DisparitiesHispanic or LatinoHospital CostsHumansInsurance, HealthLinear ModelsMaleMiddle AgedMultivariate AnalysisRacial GroupsRisk FactorsUnited StatesVascular Surgical ProceduresWhite PeopleConceptsAortic aneurysm repairThoracoabdominal aortic aneurysm repairHospital operative volumePostoperative complicationsAneurysm repairThoracoabdominal aneurysmsHispanic patientsHispanic ethnicityOperative volumeMultivariate analysisEthnic disparitiesAbdominal aortic aneurysm repairAnnual surgical volumeThoracoabdominal aortic aneurysmsClinical Modification codesNationwide Inpatient SamplePreoperative comorbiditiesIndex hospitalizationSecondary outcomesDiabetes mellitusPrimary outcomeWhite patientsBlack patientsCerebrovascular diseaseNinth RevisionMuscular effects of statins in the elderly female: a review
Bhardwaj S, Selvarajah S, Schneider E. Muscular effects of statins in the elderly female: a review. Clinical Interventions In Aging 2013, Volume 8: 47-59. PMID: 23355775, PMCID: PMC3552608, DOI: 10.2147/cia.s29686.Peer-Reviewed Original ResearchConceptsMuscle disordersElderly femalesMuscular effectsMuscle-related side effectsIncidence of statinLong-term outcomesOverall patient complianceOlder adult womenOverall incidenceCardiovascular healthElderly womenPatient complianceStatinsSide effectsAdult womenOlder individualsYoung individualsAppropriate useDisordersSignificant reductionVulnerable groupsIncidenceWomenFemalesPatients
2012
Patient Readmission and Mortality after Colorectal Surgery for Colon Cancer: Impact of Length of Stay Relative to Other Clinical Factors
Schneider E, Hyder O, Brooke B, Efron J, Cameron J, Edil B, Schulick R, Choti M, Wolfgang C, Pawlik T. Patient Readmission and Mortality after Colorectal Surgery for Colon Cancer: Impact of Length of Stay Relative to Other Clinical Factors. Journal Of The American College Of Surgeons 2012, 214: 390-398. PMID: 22289517, DOI: 10.1016/j.jamcollsurg.2011.12.025.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedAged, 80 and overCohort StudiesColectomyColorectal NeoplasmsComorbidityFemaleHospital MortalityHumansKaplan-Meier EstimateLength of StayLogistic ModelsMaleMedicarePatient ReadmissionPostoperative ComplicationsQuality Indicators, Health CareRegistriesRetrospective StudiesRisk FactorsTreatment OutcomeUnited StatesConceptsColorectal surgeryReadmission ratesColon cancerEnd Results-Medicare datasetMultiple preoperative comorbiditiesLow anterior resectionPrimary surgical treatmentRisk of readmissionPrimary colorectal cancerNumber of patientsLogistic regression modelsHospital performance measuresPreoperative comorbiditiesAnterior resectionHospital morbidityNationwide cohortPostoperative complicationsAbdominoperineal resectionMean LOSPatient ageTotal colectomyClinical factorsMore patientsSurgical treatmentColorectal cancer
2011
Premorbid Statin Use Is Associated With Improved Survival and Functional Outcomes in Older Head-Injured Individuals
Schneider E, Efron D, MacKenzie E, Rivara F, Nathens A, Jurkovich G. Premorbid Statin Use Is Associated With Improved Survival and Functional Outcomes in Older Head-Injured Individuals. Journal Of Trauma And Acute Care Surgery 2011, 71: 815-819. PMID: 21986733, DOI: 10.1097/ta.0b013e3182319de5.Peer-Reviewed Original ResearchConceptsPreinjury statin usePremorbid statin useAbbreviated Injury ScoreStatin useFunctional outcomeCardiovascular comorbiditiesStatin usersFunctional recoveryHead traumaMonths postinjuryExtended Glasgow Outcome Scale scoreGlasgow Outcome Scale scoreExtended Glasgow Outcome ScaleHours of admissionTraumatic brain injury victimsGlasgow Outcome ScaleSevere head traumaTime of injuryPossible protective agentsHead-injured individualsBrain injury victimsHospital deathHospital mortalityInjury characteristicsInjury scoreGlobal Surgical Package Reimbursement and the Acute Care Surgeon: A Threat to Optimal Care
Schneider E, Haider A, Lidor A, Efron J, Villegas C, Stevens K, Hirani S, Haut E, Efron D. Global Surgical Package Reimbursement and the Acute Care Surgeon: A Threat to Optimal Care. Journal Of Trauma And Acute Care Surgery 2011, 70: 583-589. PMID: 21610346, DOI: 10.1097/ta.0b013e3182098a30.Peer-Reviewed Original ResearchConceptsLength of stayElective right hemicolectomyEmergency surgical patientsElective patientsRight hemicolectomyEmergent patientsInhospital mortalityGreater comorbiditySurgical patientsOptimal careNationwide Inpatient Sample dataAcute care surgery serviceEmergent right hemicolectomyPatient LOSAcute care surgeonsEmergency surgery patientsHigher mortality riskMann-Whitney testSurgery patientsSurgery serviceInpatient admissionsInsurance statusMortality riskMultivariable regressionGreater odds
2008
Preinjury Statin Use is Associated With Improved In-Hospital Survival in Elderly Trauma Patients
Efron D, Sorock G, Haut E, Chang D, Schneider E, MacKenzie E, Cornwell E, Jurkovich G. Preinjury Statin Use is Associated With Improved In-Hospital Survival in Elderly Trauma Patients. Journal Of Trauma And Acute Care Surgery 2008, 64: 66-74. PMID: 18188101, DOI: 10.1097/ta.0b013e31815b842a.Peer-Reviewed Original ResearchConceptsPreinjury statin useElderly trauma patientsStatin useElderly patientsHospital mortalityTrauma patientsRetrospective observational cohort studyNew Injury Severity ScoreCerebral midline shiftIn-Hospital SurvivalMultivariable adjusted oddsBeta-blocker useObservational cohort studySignificant survival benefitGlutaryl-CoA reductase inhibitorsInjury Severity ScoreGlasgow Coma ScaleTime of injurySevere traumatic injurySample of patientsTrauma center treatmentCardiovascular comorbiditiesHospital deathStatin therapyCohort study