2023
Diverticulitis in Older Adults: Is Cognitive Impairment Associated With Outcomes?
Kodadek L, Moore M, Canner J, Schneider E. Diverticulitis in Older Adults: Is Cognitive Impairment Associated With Outcomes? Journal Of Surgical Research 2023, 291: 359-366. PMID: 37506436, DOI: 10.1016/j.jss.2023.06.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedCognitive DysfunctionDiverticulitisDiverticulitis, ColonicHumansRetrospective StudiesRisk FactorsConceptsColonic diverticulitisCognitive impairmentEmergency departmentOlder adultsHospital mortalityOperative interventionInpatient admissionsPrimary diagnosisMultivariable Poisson regression modelsNationwide Emergency Department SamplePrimary payer statusRetrospective cohort studyElixhauser Comorbidity IndexEmergency Department SampleComorbid cognitive impairmentPoisson regression modelsComorbidity indexComplicated diverticulitisCognitive impairment statusCohort studyED encountersPatient ageED carePayer statusRelative risk
2019
Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort
Hawkins R, Mehaffey J, Charles E, Kern J, Schneider E, Tracci M. Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort. Journal Of Vascular Surgery 2019, 70: 1985-1993.e8. PMID: 31761106, DOI: 10.1016/j.jvs.2019.03.060.Peer-Reviewed Original ResearchConceptsDistressed Communities IndexMajor adverse limb eventsAdverse limb eventsInfrainguinal bypassGraft occlusionIndependent predictorsLimb eventsMajor adverse cardiovascular eventsLong-term maleAdverse cardiovascular eventsOperative risk factorsCritical limb ischemiaMore comorbid diseasesCare-related outcomesHealth care-related outcomesPrior amputationHospital mortalityCardiovascular eventsComorbid diseasesLimb ischemiaSurgical outcomesNational cohortVascular diseaseRisk factorsUnivariate analysis
2018
The “mortality ascent”
Herrera-Escobar JP, Rios-Diaz AJ, Zogg CK, Wolf LL, Harlow A, Schneider EB, Cooper Z, Ordonez CA, Salim A, Haider AH. The “mortality ascent”. Journal Of Trauma And Acute Care Surgery 2018, 84: 139-145. PMID: 28930947, DOI: 10.1097/ta.0000000000001706.Peer-Reviewed Original ResearchConceptsUnstable trauma patientsLevel I TCsLevel II TCsHours postadmissionTrauma patientsLevel ILevel IIMortality riskHospital mortalityLog-binomial regression modelsNational Trauma Data BankComparable mortality riskHospital-level confoundersInjury Severity ScoreSystolic blood pressureAvailable treatment modalitiesTrauma Data BankSpecific risk factorsRisk-adjusted modelsBlood pressureHigher relative mortalityUnstable patientsBurn patientsSeverity scoreTreatment modalities
2017
Financial Impact of Acute Kidney Injury After Cardiac Operations in the United States
Alshaikh H, Katz N, Gani F, Nagarajan N, Canner J, Kacker S, Najjar P, Higgins R, Schneider E. Financial Impact of Acute Kidney Injury After Cardiac Operations in the United States. The Annals Of Thoracic Surgery 2017, 105: 469-475. PMID: 29275828, DOI: 10.1016/j.athoracsur.2017.10.053.Peer-Reviewed Original ResearchConceptsAcute kidney injuryIndex hospitalization costsTotal index hospitalization costsIndex hospital costsCardiac operationsHospitalization costsKidney injuryDevelopment of AKISubstantial health care cost savingsClinical Modification diagnosis codesHealth care cost savingsMajor cardiac operationsCoronary artery bypassChronic renal failureNationwide Inpatient SampleMajor cardiac proceduresLong-term treatmentArtery bypassRenal failureValve replacementReplacement patientsAvoidable complicationsCardiac proceduresPatient morbidityDiagnosis codes
2016
Epidemiologic Trends of Chemical Ocular Burns in the United States
Haring R, Sheffield I, Channa R, Canner J, Schneider E. Epidemiologic Trends of Chemical Ocular Burns in the United States. JAMA Ophthalmology 2016, 134: 1119-1124. PMID: 27490908, DOI: 10.1001/jamaophthalmol.2016.2645.Peer-Reviewed Original ResearchConceptsChemical ocular burnsEmergency departmentOcular burnsEpidemiologic trendsAcid injuryHealth care insuranceChemical burnsNationwide Emergency Department SampleChemical eye injuriesEmergency department chargesTotal emergency departmentOcular chemical burnsOcular chemical injuryEmergency Department SampleHigh-risk groupSingle high-risk groupAge-specific ratesPrivate health care insuranceCare insuranceAlkali injuryED presentationsEye injuriesMedian agePatient ageFemale patientsOutcomes of abdominoperineal resection for management of anal cancer in HIV-positive patients: a national case review
Leeds IL, Alturki H, Canner JK, Schneider EB, Efron JE, Wick EC, Gearhart SL, Safar B, Fang SH. Outcomes of abdominoperineal resection for management of anal cancer in HIV-positive patients: a national case review. World Journal Of Surgical Oncology 2016, 14: 208. PMID: 27495294, PMCID: PMC4974747, DOI: 10.1186/s12957-016-0970-x.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAdultAge FactorsAgedAnus NeoplasmsCarcinoma, Squamous CellComorbidityFemaleFollow-Up StudiesHealth Status DisparitiesHIV InfectionsHospital MortalityHumansIncidenceLength of StayMaleMiddle AgedNeoplasm Recurrence, LocalPerineumPostoperative ComplicationsRetrospective StudiesRisk FactorsSalvage TherapyTreatment OutcomeConceptsHIV-positive patientsLength of stayHIV-negative patientsAnal cancerNational Inpatient SampleAbdominoperineal resectionHospitalization costsHIV infectionAnal squamous cell cancerAnal squamous cell carcinomaUtilization Project National Inpatient SampleGreater hospitalization costsWorse postoperative recoveryHIV-positive groupMethodsA retrospective reviewAnal cancer patientsSquamous cell cancerHuman immunodeficiency virusMultivariable logistic regressionSquamous cell carcinomaHospital mortalityHospital stayPerioperative complicationsPostoperative hemorrhagePostoperative outcomesEpidemiology of Eye-Related Emergency Department Visits
Channa R, Zafar SN, Canner JK, Haring RS, Schneider EB, Friedman DS. Epidemiology of Eye-Related Emergency Department Visits. JAMA Ophthalmology 2016, 134: 312. PMID: 26821577, DOI: 10.1001/jamaophthalmol.2015.5778.Peer-Reviewed Original ResearchConceptsNationwide Emergency Department SampleED visitsEmergency departmentIncidence rateUS Nationwide Emergency Department SampleAge groupsPopulation-based incidence ratesEmergency Department SampleInflation-adjusted chargesHighest income quartileDifferent age groupsEmergent visitsCorneal abrasionOlder patientsEye injuriesSubconjunctival hemorrhageNonemergent conditionsOcular problemsOcular conditionsNonemergent visitsExternal eyeEye problemsForeign bodyMAIN OUTCOMEIndependent factorsA novel score to estimate the risk of pneumonia after cardiac surgery
Kilic A, Ohkuma R, Grimm J, Magruder J, Sussman M, Schneider E, Whitman G. A novel score to estimate the risk of pneumonia after cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2016, 151: 1415-1421. PMID: 27085620, DOI: 10.1016/j.jtcvs.2015.12.049.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedCardiac Surgical ProceduresCardiopulmonary BypassCohort StudiesFemaleHumansIncidenceMaleMiddle AgedMultivariate AnalysisPneumoniaPostoperative ComplicationsRegression AnalysisRetrospective StudiesRisk FactorsSeverity of Illness IndexSex DistributionSurvival RateUnited StatesConceptsCardiac surgeryPostoperative pneumoniaRisk scoreValidation cohortRisk factorsMultivariable modelRate of pneumoniaRisk of pneumoniaSingle-institution databaseSignificant risk factorsComposite scoreIntraoperative predictorsPerioperative managementPrimary outcomeTraining cohortPneumoniaSurgeryNovel scorePreventative interventionsCohortOverall rateScoresPatientsSignificant correlationRegression analysis
2015
Emergent Surgery Does Not Independently Predict 30-Day Mortality After Paraesophageal Hernia Repair: Results from the ACS NSQIP Database
Augustin T, Schneider E, Alaedeen D, Kroh M, Aminian A, Reznick D, Walsh M, Brethauer S. Emergent Surgery Does Not Independently Predict 30-Day Mortality After Paraesophageal Hernia Repair: Results from the ACS NSQIP Database. Journal Of Gastrointestinal Surgery 2015, 19: 2097-2104. PMID: 26467561, DOI: 10.1007/s11605-015-2968-z.Peer-Reviewed Original ResearchConceptsNational Surgical Quality Improvement ProgramChronic obstructive pulmonary diseaseCongestive heart failureNationwide Inpatient SampleParaesophageal hernia repairEmergent surgeryEmergent patientsPEH repairHernia repairSurgical Quality Improvement ProgramPatient-level risk factorsAdjusted mortality riskElective surgery groupModified Frailty IndexACS-NSQIP databaseHigher American SocietyHigher frailty scoresObstructive pulmonary diseaseElective surgical interventionSeverity of diseaseQuality Improvement ProgramEmergent indicationsPreoperative sepsisBMI 25Comorbid illnessesElevated relative risk of aneurysmal subarachnoid hemorrhage with colder weather in the mid-Atlantic region
Rivera-Lara L, Kowalski R, Schneider E, Tamargo R, Nyquist P. Elevated relative risk of aneurysmal subarachnoid hemorrhage with colder weather in the mid-Atlantic region. Journal Of Clinical Neuroscience 2015, 22: 1582-1587. PMID: 26149403, DOI: 10.1016/j.jocn.2015.03.033.Peer-Reviewed Original ResearchThirty-day readmission after lower extremity bypass in diabetic patients
Najafian A, Selvarajah S, Schneider EB, Malas MB, Ehlert BA, Orion KC, Haider AH, Abularrage CJ. Thirty-day readmission after lower extremity bypass in diabetic patients. Journal Of Surgical Research 2015, 200: 356-364. PMID: 26216749, DOI: 10.1016/j.jss.2015.06.061.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetic mellitusLower extremity bypassUnplanned readmissionCardiac diseaseCardiac complicationsExtremity bypassDiabetic mellitusSurgeons National Surgery Quality Improvement Program databaseNational Surgery Quality Improvement Program databaseInfrainguinal lower extremity bypassQuality Improvement Program databaseConcomitant cardiac diseaseDependent diabetic mellitusThirty-day readmissionImprovement Program databasePeripheral vascular diseaseUnplanned readmission rateInfluence of diabetesSignificant risk factorsPostoperative complicationsCardiac workupReadmission ratesDiabetic patientsIndependent predictorsMultivariable analysisDiagnostic Frequency Ratios Are Insufficient to Measure Laboratory Precision with The Bethesda System for Reporting Thyroid Cytopathology
Fazeli R, Schneider EB, Ali SZ, Zeiger MA, Olson MT. Diagnostic Frequency Ratios Are Insufficient to Measure Laboratory Precision with The Bethesda System for Reporting Thyroid Cytopathology. Acta Cytologica 2015, 59: 225-232. PMID: 26022342, DOI: 10.1159/000379738.Peer-Reviewed Original ResearchTrends in Incident Hemodialysis Access and Mortality
Malas MB, Canner JK, Hicks CW, Arhuidese IJ, Zarkowsky DS, Qazi U, Schneider EB, Black JH, Segev DL, Freischlag JA. Trends in Incident Hemodialysis Access and Mortality. JAMA Surgery 2015, 150: 441-448. PMID: 25738981, DOI: 10.1001/jamasurg.2014.3484.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseHemodialysis cathetersArteriovenous fistulaArteriovenous graftsLower mortalityRenal diseaseVascular accessHD outcomesNational Kidney Foundation Kidney Disease Outcomes Quality InitiativeKidney Foundation Kidney Disease Outcomes Quality InitiativeMultivariable Cox proportional hazards modelsPrior renal replacement therapyUS Renal Data SystemCox proportional hazards modelArteriovenous fistula useIncident HD patientsInitiation of hemodialysisRetrospective cohort studyRenal replacement therapyProportional hazards modelFistula useCohort studySurvival benefitHD patientsPropensity score-matching techniqueNational estimates of predictors of outcomes for emergency general surgery
Shah AA, Haider AH, Zogg CK, Schwartz DA, Haut ER, Zafar SN, Schneider EB, Velopulos CG, Shafi S, Zafar H, Efron DT. National estimates of predictors of outcomes for emergency general surgery. Journal Of Trauma And Acute Care Surgery 2015, 78: 482-491. PMID: 25710417, DOI: 10.1097/ta.0000000000000555.Peer-Reviewed Original ResearchConceptsEmergency general surgeryEGS patientsMajor complicationsGeneral surgeryMultivariate logistic regression analysisOverall complication ratePredictors of mortalityClinical Modification codesOverall mortality rateNationwide Inpatient SampleSeparate multivariate logistic regression analysesSurgery of TraumaDRG International ClassificationLogistic regression analysisHighest income quartileHospital complicationsHospital mortalityComplication ratePatient demographicsSurgical complicationsIndependent predictorsPrimary outcomeEGS conditionsMean ageInpatient SampleTraumatic brain injury in the elderly: morbidity and mortality trends and risk factors
Haring R, Narang K, Canner J, Asemota A, George B, Selvarajah S, Haider A, Schneider E. Traumatic brain injury in the elderly: morbidity and mortality trends and risk factors. Journal Of Surgical Research 2015, 195: 1-9. PMID: 25724764, DOI: 10.1016/j.jss.2015.01.017.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryMechanism of injuryBrain injuryTBI-related deathsTBI-related hospitalizationOdds of deathMultivariable logistic regressionNationwide Inpatient SampleLogistic regression analysisOlder age groupsMore comorbiditiesMale patientsPayer statusTBI patientsInpatient SampleRisk factorsHigher oddsInjury severityPatientsMortality trendsAge groupsInjuryLogistic regressionTBI dataComorbidities
2014
Presence of Haptoglobin-2 Allele Is Associated with Worse Functional Outcomes After Spontaneous Intracerebral Hemorrhage
Murthy SB, Levy AP, Duckworth J, Schneider EB, Shalom H, Hanley DF, Tamargo RJ, Nyquist PA. Presence of Haptoglobin-2 Allele Is Associated with Worse Functional Outcomes After Spontaneous Intracerebral Hemorrhage. World Neurosurgery 2014, 83: 583-587. PMID: 25527876, DOI: 10.1016/j.wneu.2014.12.013.Peer-Reviewed Original ResearchVariation in Readmission by Hospital After Colorectal Cancer Surgery
Lucas D, Ejaz A, Bischof D, Schneider E, Pawlik T. Variation in Readmission by Hospital After Colorectal Cancer Surgery. JAMA Surgery 2014, 149: 1272-1277. PMID: 25337956, DOI: 10.1001/jamasurg.2014.988.Peer-Reviewed Original ResearchConceptsReadmission ratesColorectal surgeryAppropriate risk adjustmentHierarchical multivariable logistic regression analysisMultivariable logistic regression analysisRisk-adjusted readmission ratesRisk adjustmentRepresentative cancer registryColorectal cancer surgeryEnd Results-MedicareHospital readmission ratesHospital quality metricsRisk-adjusted variationLogistic regression analysisColorectal resectionStudy patientsHospital readmissionMedian agePatient characteristicsCancer surgeryCancer RegistryMAIN OUTCOMEReadmissionUS hospitalsHospitalHospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough?
Schneider EB, Ejaz A, Spolverato G, Hirose K, Makary MA, Wolfgang CL, Ahuja N, Weiss M, Pawlik TM. Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough? Journal Of Gastrointestinal Surgery 2014, 18: 2105-2115. PMID: 25297443, DOI: 10.1007/s11605-014-2619-9.Peer-Reviewed Original ResearchConceptsLength of stayHV hospitalsHV centersHospital volumeMajor complicationsLV centersBiliary surgeryHPB surgeryHospital patientsShorter median LOSMedian LOSComplex HPB surgeryHospital volume strataIncidence of complicationsPost-operative complicationsOverall mean ageHepato-PancreaticoLV hospitalsMedical comorbiditiesImpact of regionalizationMean ageBiliary proceduresHemorrhagic anemiaPatient outcomesIndex mortalityDevelopment of a duplex-derived velocity risk prediction model of disease progression in patients with moderate asymptomatic carotid artery stenosis
Hicks CW, Canner JK, Arhuidese I, Glebova NO, Schneider E, Qazi U, Perler B, Malas MB. Development of a duplex-derived velocity risk prediction model of disease progression in patients with moderate asymptomatic carotid artery stenosis. Journal Of Vascular Surgery 2014, 60: 1585-1592. PMID: 25238724, DOI: 10.1016/j.jvs.2014.08.056.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArea Under CurveAsymptomatic DiseasesBlood Flow VelocityCarotid Artery, CommonCarotid Artery, InternalCarotid StenosisChi-Square DistributionDecision Support TechniquesDisease ProgressionFemaleHumansMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProportional Hazards ModelsRegional Blood FlowRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsUltrasonography, Doppler, DuplexConceptsAsymptomatic carotid artery stenosisICA/CCA ratioCarotid artery stenosisInternal carotid arteryDisease progressionEnd-diastolic velocityPeak systolic velocityRisk prediction modelCCA ratioArtery stenosisSystolic velocityRisk factorsInitial peak systolic velocityProportional hazards regression modelsHigh-risk patientsRisk of progressionRisk-stratify patientsHazards regression modelsSignificant independent predictorsICA/CCACharacteristic curve analysisClinical prediction modelCarotid artery ratioIndependent predictorsDuplex imagingEncephalitis Hospitalization Rates and Inpatient Mortality in the United States, 2000-2010
George B, Schneider E, Venkatesan A. Encephalitis Hospitalization Rates and Inpatient Mortality in the United States, 2000-2010. PLOS ONE 2014, 9: e104169. PMID: 25192177, PMCID: PMC4156306, DOI: 10.1371/journal.pone.0104169.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleHospitalization ratesEncephalitis hospitalizationsInpatient mortalitySpecified causeComorbid HIV/AIDSAcute phase outcomesComorbid HIV infectionDiagnosis of encephalitisOdds of mortalityRetrospective observational studyCommon infectious agentsAcute care hospitalsYears of ageHerpes simplex virusHIV/AIDSAutoimmune conditionsCare hospitalHIV infectionWest Nile virusCause-specific ratesEncephalitis patientsViral causeAdjusted oddsInpatient Sample