2024
Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriovenous FistulaArteriovenous Shunt, SurgicalDown-RegulationFemaleGene Expression ProfilingGene Expression RegulationMaleMiceMice, Inbred C57BLRenal DialysisVascular RemodelingVeinsConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidity
2023
Arterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation
Satam K, Setia O, Moore M, Schneider E, Chaar C, Dardik A. Arterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2023, 93: 128-136. PMID: 36812979, PMCID: PMC10277224, DOI: 10.1016/j.avsg.2023.01.052.Peer-Reviewed Original ResearchMeSH KeywordsArteriovenous FistulaArteriovenous Shunt, SurgicalBrachial ArteryFemaleHumansMaleMonocytesRenal DialysisRetrospective StudiesTreatment OutcomeVascular PatencyConceptsFistula maturationArteriovenous fistula maturationArterial diameterArteriovenous fistulaFistula creationBrachial artery diameterPrimary arteriovenous fistulaPercentage of neutrophilsPeak systolic velocityPercentage of monocytesBrachial-cephalic fistulaElectronic medical recordsSex differencesFistula utilizationInferior patencyPostoperative ultrasoundUnassisted maturationYears postprocedureSingle centerArtery diameterArterial inflowArterial velocitySystolic velocityMedical recordsMonocyte percentage
2015
Quality Improvement Targets for Regional Variation in Surgical End-Stage Renal Disease Care
Zarkowsky DS, Hicks CW, Arhuidese I, Canner JK, Obeid T, Qazi U, Schneider E, Abularrage CJ, Black JH, Freischlag JA, Malas MB. Quality Improvement Targets for Regional Variation in Surgical End-Stage Renal Disease Care. JAMA Surgery 2015, 150: 764-770. PMID: 26107005, DOI: 10.1001/jamasurg.2015.1126.Peer-Reviewed Original ResearchMeSH KeywordsAgedArteriovenous Shunt, SurgicalFemaleHumansIncidenceKidney Failure, ChronicMaleMiddle AgedQuality ImprovementRenal DialysisRetrospective StudiesRisk AdjustmentUnited StatesConceptsEnd-stage renal diseaseUS Renal Data SystemFirst hemodialysisNephrology careAVF accessMortality hazardEnd-stage renal disease careLogistic regressionCongestive heart failureRenal replacement therapyMultivariable logistic regressionArteriovenous fistula accessQuality improvement targetsPatient comorbiditiesHeart failurePatient characteristicsRenal diseaseDisease careESRD mortalityReplacement therapyFistula accessUnivariate analysisRetrospective analysisBest practice guidelinesMAIN OUTCOMERacial/Ethnic Disparities Associated With Initial Hemodialysis Access
Zarkowsky DS, Arhuidese IJ, Hicks CW, Canner JK, Qazi U, Obeid T, Schneider E, Abularrage CJ, Freischlag JA, Malas MB. Racial/Ethnic Disparities Associated With Initial Hemodialysis Access. JAMA Surgery 2015, 150: 529-536. PMID: 25923973, DOI: 10.1001/jamasurg.2015.0287.Peer-Reviewed Original ResearchConceptsMedical insurance statusEnd-stage renal diseaseUS Renal Data SystemInitial hemodialysis accessWhite patientsArteriovenous fistulaBlack patientsHispanic patientsRace/ethnicityNephrology careInsurance statusRenal diseaseHemodialysis accessChronic obstructive pulmonary diseaseLogistic regressionMore white patientsInfluence of comorbiditiesObstructive pulmonary diseaseRacial/Ethnic DisparitiesCoronary artery diseaseCategory of patientsMultivariable logistic regressionPatterns of utilizationDifferent races/ethnicitiesFistula utilizationTrends in Incident Hemodialysis Access and Mortality
Malas MB, Canner JK, Hicks CW, Arhuidese IJ, Zarkowsky DS, Qazi U, Schneider EB, Black JH, Segev DL, Freischlag JA. Trends in Incident Hemodialysis Access and Mortality. JAMA Surgery 2015, 150: 441-448. PMID: 25738981, DOI: 10.1001/jamasurg.2014.3484.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseHemodialysis cathetersArteriovenous fistulaArteriovenous graftsLower mortalityRenal diseaseVascular accessHD outcomesNational Kidney Foundation Kidney Disease Outcomes Quality InitiativeKidney Foundation Kidney Disease Outcomes Quality InitiativeMultivariable Cox proportional hazards modelsPrior renal replacement therapyUS Renal Data SystemCox proportional hazards modelArteriovenous fistula useIncident HD patientsInitiation of hemodialysisRetrospective cohort studyRenal replacement therapyProportional hazards modelFistula useCohort studySurvival benefitHD patientsPropensity score-matching technique