Blood-Based Biomarkers of Repetitive, Subconcussive Blast Overpressure Exposure in the Training Environment: A Pilot Study
Agoston D, McCullough J, Aniceto R, Lin I, Kamnaksh A, Eklund M, Graves W, Dunbar C, Engall J, Schneider E, Leonessa F, Duckworth J. Blood-Based Biomarkers of Repetitive, Subconcussive Blast Overpressure Exposure in the Training Environment: A Pilot Study. Neurotrauma Reports 2022, 3: 479-490. PMID: 36337080, PMCID: PMC9634979, DOI: 10.1089/neur.2022.0029.Peer-Reviewed Original ResearchTraumatic brain injuryMatrix metalloprotease-9Serum levelsClaudin-5Ubiquitin C-terminal hydrolase L1Pilot studyUnknown long-term effectsElevated autoantibody titersGlial fibrillary acidic proteinMild traumatic brain injuryElevated serum levelsBlood-based biomarkersAlpha 7 subunitChronic degenerative processMolecular changesFibrillary acidic proteinBlast overpressure exposureAutoantibody titersAutoimmune processVascular changesElevated titersBrain injuryLong-term effectsBlood samplesMetalloprotease-9