Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study
Zysk AM, Chen K, Gabrielson E, Tafra L, May Gonzalez EA, Canner JK, Schneider EB, Cittadine AJ, Scott Carney P, Boppart SA, Tsuchiya K, Sawyer K, Jacobs LK. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study. Annals Of Surgical Oncology 2015, 22: 3356-3362. PMID: 26202553, PMCID: PMC4839389, DOI: 10.1245/s10434-015-4665-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularFeasibility StudiesFemaleFollow-Up StudiesHumansIntraoperative PeriodMastectomy, SegmentalMicrosurgeryMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisProspective StudiesReoperationTomography, Optical CoherenceConceptsBreast-conserving surgeryPositive marginsFinal marginsIntraoperative assessmentEarly-stage breast cancerMajority of reoperationsBreast conserving surgeryFinal surgical marginsMethodsForty-six patientsCavity shave marginsJohns Hopkins HospitalReoperation rateMargin statusSitu diseaseSurgical marginsMulticenter studyPostoperative histopathologyNegative marginsResultsA totalPatient outcomesSpecimen marginsBreast cancerMedical CenterMargin specimensBlinded study