2019
Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort
Hawkins R, Mehaffey J, Charles E, Kern J, Schneider E, Tracci M. Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort. Journal Of Vascular Surgery 2019, 70: 1985-1993.e8. PMID: 31761106, DOI: 10.1016/j.jvs.2019.03.060.Peer-Reviewed Original ResearchConceptsDistressed Communities IndexMajor adverse limb eventsAdverse limb eventsInfrainguinal bypassGraft occlusionIndependent predictorsLimb eventsMajor adverse cardiovascular eventsLong-term maleAdverse cardiovascular eventsOperative risk factorsCritical limb ischemiaMore comorbid diseasesCare-related outcomesHealth care-related outcomesPrior amputationHospital mortalityCardiovascular eventsComorbid diseasesLimb ischemiaSurgical outcomesNational cohortVascular diseaseRisk factorsUnivariate analysis
2018
Neutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases
McDermott SM, Saunders ND, Schneider EB, Strosberg D, Onesti J, Dillhoff M, Schmidt CR, Shirley LA. Neutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases. Journal Of Surgical Research 2018, 232: 369-375. PMID: 30463743, DOI: 10.1016/j.jss.2018.06.058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChemoembolization, TherapeuticFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLeukocyte CountLiver NeoplasmsLymphocytesMaleMiddle AgedNeuroendocrine TumorsNeutrophilsPreoperative PeriodPrognosisResponse Evaluation Criteria in Solid TumorsRetrospective StudiesYoung AdultConceptsMedian overall survivalMetastatic neuroendocrine tumorsTransarterial chemoembolizationOverall survivalNeuroendocrine tumorsSingle tertiary medical centerCancer-related treatmentTertiary medical centerNeuroendocrine tumor metastasesPotential treatment strategyElevated NLRLiver metastasesNLR valuesIndependent predictorsBlood workLymphocyte ratioEntire cohortTreatment strategiesPostprocedural careMedical CenterPatientsMultivariate analysisNLRTumor metastasisChemoembolization
2017
A Novel Risk Score to Predict the Need for Nutrition Support After Cardiac Surgery
Ohkuma R, Crawford T, Brown P, Grimm J, Magruder J, Kilic A, Suarez-Pierre A, Snyder S, Wood J, Schneider E, Sussman M, Whitman G. A Novel Risk Score to Predict the Need for Nutrition Support After Cardiac Surgery. The Annals Of Thoracic Surgery 2017, 104: 1306-1312. PMID: 28625392, DOI: 10.1016/j.athoracsur.2017.03.013.Peer-Reviewed Original ResearchConceptsPostoperative nutrition supportNutrition supportCardiac surgeryNS scoresAdult cardiac surgery patientsMultivariable logistic regression modelingEarly postoperative nutritionMalnutrition-related morbidityCardiac surgery patientsNovel risk scoreRelative odds ratioLogistic regression modelingTiming of initiationPostoperative nutritionSurgery patientsDerivation cohortIndependent predictorsPredictive screening toolMultivariable analysisValidation cohortC-statisticOdds ratioHigh riskRisk scorePatients
2016
Predictors of emergency ventral hernia repair: Targets to improve patient access and guide patient selection for elective repair
Wolf LL, Scott JW, Zogg CK, Havens JM, Schneider EB, Smink DS, Salim A, Haider AH. Predictors of emergency ventral hernia repair: Targets to improve patient access and guide patient selection for elective repair. Surgery 2016, 160: 1379-1391. PMID: 27542434, DOI: 10.1016/j.surg.2016.06.027.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overConfidence IntervalsDatabases, FactualElective Surgical ProceduresEmergenciesFemaleFollow-Up StudiesHealth Services AccessibilityHernia, VentralHerniorrhaphyHospital MortalityHumansInsurance CoverageLogistic ModelsMaleMiddle AgedOdds RatioPatient SelectionPredictive Value of TestsQuality ImprovementRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeConceptsVentral hernia repairEmergency ventral hernia repairHospital-level factorsHernia repairIndependent predictorsPatient selectionElective operationsWorse outcomesEmergency repairLonger hospital stayNationwide Inpatient SampleMultivariable logistic regressionUnited States populationRace/ethnicityHospital deathHospital staySecondary outcomesElective repairPrimary outcomePayer statusInpatient SamplePatient outcomesVentral herniasElective careGreater oddsAssociation of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers
Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid 2016, 26: 532-542. PMID: 26950846, PMCID: PMC4827320, DOI: 10.1089/thy.2015.0378.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionMultivariable logistic regression analysisPapillary thyroid cancerProphylactic central lymph node dissectionLogistic regression analysisLymph node dissectionAggressive clinicopathologic featuresLymph node metastasisEndocrine surgery centersStand-alone markerClinicopathologic featuresMiR-146bNode dissectionIndependent predictorsNode metastasisMiR-222Surgery centersThyroid cancerProphylactic lymph node dissectionRegression analysisIndividual prognostic markersOnly preoperative variablesNode-negative casesMicroRNA expressionHaptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage
Murthy S, Caplan J, Levy A, Pradilla G, Moradiya Y, Schneider E, Shalom H, Ziai W, Tamargo R, Nyquist P. Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage. Neurosurgery 2016, 78: 71-76. PMID: 26348010, DOI: 10.1227/neu.0000000000001000.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageCerebral infarctionSubarachnoid hemorrhageHp genotypeHp 2Cerebral Salt Wasting SyndromeGlasgow Outcome ScoreCerebral saltUrine sodiumBaseline characteristicsSymptomatic vasospasmIndependent predictorsUrine outputClinical outcomesOutcome scoresSubsequent vasospasmFunctional outcomeProspective confirmationMultivariate regression modelGenotype testingHaptoglobin 2Haptoglobin genotypeOutcome measuresHemorrhagePatients
2015
MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review
Han P, Weng C, Khawaja H, Nagarajan N, Schneider E, Umbricht C, Witwer K, Zeiger M. MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review. Thyroid 2015, 25: 1322-1329. PMID: 26414548, DOI: 10.1089/thy.2015.0193.Peer-Reviewed Original ResearchConceptsAggressive clinicopathologic featuresPapillary thyroid cancerClinicopathologic featuresThyroid cancerRoutine central lymph node dissectionSystematic reviewCentral lymph node dissectionMiR expression levelsLymph node dissectionLymph node metastasisLarger tumor sizeUseful prognostic markerExpression levelsWeb of ScienceFull-text publicationsNode dissectionLymphovascular invasionDistant metastasisIndependent predictorsNode metastasisAggressive featuresPrognostic significanceProspective studyTumor sizePrognostic markerThirty-day readmission after lower extremity bypass in diabetic patients
Najafian A, Selvarajah S, Schneider EB, Malas MB, Ehlert BA, Orion KC, Haider AH, Abularrage CJ. Thirty-day readmission after lower extremity bypass in diabetic patients. Journal Of Surgical Research 2015, 200: 356-364. PMID: 26216749, DOI: 10.1016/j.jss.2015.06.061.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetic mellitusLower extremity bypassUnplanned readmissionCardiac diseaseCardiac complicationsExtremity bypassDiabetic mellitusSurgeons National Surgery Quality Improvement Program databaseNational Surgery Quality Improvement Program databaseInfrainguinal lower extremity bypassQuality Improvement Program databaseConcomitant cardiac diseaseDependent diabetic mellitusThirty-day readmissionImprovement Program databasePeripheral vascular diseaseUnplanned readmission rateInfluence of diabetesSignificant risk factorsPostoperative complicationsCardiac workupReadmission ratesDiabetic patientsIndependent predictorsMultivariable analysisNational estimates of predictors of outcomes for emergency general surgery
Shah AA, Haider AH, Zogg CK, Schwartz DA, Haut ER, Zafar SN, Schneider EB, Velopulos CG, Shafi S, Zafar H, Efron DT. National estimates of predictors of outcomes for emergency general surgery. Journal Of Trauma And Acute Care Surgery 2015, 78: 482-491. PMID: 25710417, DOI: 10.1097/ta.0000000000000555.Peer-Reviewed Original ResearchConceptsEmergency general surgeryEGS patientsMajor complicationsGeneral surgeryMultivariate logistic regression analysisOverall complication ratePredictors of mortalityClinical Modification codesOverall mortality rateNationwide Inpatient SampleSeparate multivariate logistic regression analysesSurgery of TraumaDRG International ClassificationLogistic regression analysisHighest income quartileHospital complicationsHospital mortalityComplication ratePatient demographicsSurgical complicationsIndependent predictorsPrimary outcomeEGS conditionsMean ageInpatient Sample
2014
Development of a duplex-derived velocity risk prediction model of disease progression in patients with moderate asymptomatic carotid artery stenosis
Hicks CW, Canner JK, Arhuidese I, Glebova NO, Schneider E, Qazi U, Perler B, Malas MB. Development of a duplex-derived velocity risk prediction model of disease progression in patients with moderate asymptomatic carotid artery stenosis. Journal Of Vascular Surgery 2014, 60: 1585-1592. PMID: 25238724, DOI: 10.1016/j.jvs.2014.08.056.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArea Under CurveAsymptomatic DiseasesBlood Flow VelocityCarotid Artery, CommonCarotid Artery, InternalCarotid StenosisChi-Square DistributionDecision Support TechniquesDisease ProgressionFemaleHumansMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProportional Hazards ModelsRegional Blood FlowRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsUltrasonography, Doppler, DuplexConceptsAsymptomatic carotid artery stenosisICA/CCA ratioCarotid artery stenosisInternal carotid arteryDisease progressionEnd-diastolic velocityPeak systolic velocityRisk prediction modelCCA ratioArtery stenosisSystolic velocityRisk factorsInitial peak systolic velocityProportional hazards regression modelsHigh-risk patientsRisk of progressionRisk-stratify patientsHazards regression modelsSignificant independent predictorsICA/CCACharacteristic curve analysisClinical prediction modelCarotid artery ratioIndependent predictorsDuplex imagingFunctional recovery after moderate/severe traumatic brain injury
Schneider E, Sur S, Raymont V, Duckworth J, Kowalski R, Efron D, Hui X, Selvarajah S, Hambridge H, Stevens R. Functional recovery after moderate/severe traumatic brain injury. Neurology 2014, 82: 1636-1642. PMID: 24759845, PMCID: PMC4211893, DOI: 10.1212/wnl.0000000000000379.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryTraumatic brain injuryYears of educationBrain injuryDisability Rating Scale scoresProspective multicenter cohortMain outcome measuresRating Scale scoresRobust independent predictorModel Systems databaseDose-response relationshipLogistic regression modelsTBI Model Systems databaseCognitive reserveIndependent predictorsMulticenter cohortPrognostic factorsFunctional recoveryRetrospective studyDuration of educationYears postinjuryOutcome measuresPatientsScale scoreNeural adaptation
2013
Socioeconomic disparity in inpatient mortality after traumatic injury in adults
Ali M, Hui X, Hashmi Z, Dhiman N, Scott V, Efron D, Schneider E, Haider A. Socioeconomic disparity in inpatient mortality after traumatic injury in adults. Surgery 2013, 154: 461-467. PMID: 23972652, PMCID: PMC3989530, DOI: 10.1016/j.surg.2013.05.036.Peer-Reviewed Original ResearchConceptsInjury Severity ScoreInpatient mortalityMedian household incomeSocioeconomic statusTrauma mortalityInsurance statusMultiple logistic regression analysisUnadjusted inpatient mortalityNationwide Inpatient SampleType of injuryLogistic regression analysisLower wealth quartilesWealthiest quartileTrauma disparitiesPatient demographicsIndependent predictorsTrauma patientsSeverity scoreAdjusted oddsInpatient SampleTraumatic injuryInclusion criteriaAdult traumaComorbiditiesMortalityDoes BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers
Li C, Han P, Lee K, Lee L, Fox A, Beninato T, Thiess M, Dy B, Sebo T, Thompson G, Grant C, Giordano T, Gauger P, Doherty G, Fahey T, Bishop J, Eshleman J, Umbricht C, Schneider E, Zeiger M. Does BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers. The Journal Of Clinical Endocrinology & Metabolism 2013, 98: 3702-3712. PMID: 23969188, DOI: 10.1210/jc.2013-1584.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionPapillary thyroid cancerClassical variant papillary thyroid cancerRoutine central lymph node dissectionEndocrine surgery centersBRAF mutationsIndependent predictorsMultivariable analysisAggressive featuresBRAF statusSurgery centersThyroid cancerProphylactic central lymph node dissectionBivariate analysisPresence of LNMLymph node dissectionAggressive clinicopathologic featuresTumor-related factorsAmerican Joint CommitteeLymph node metastasisTreatment of patientsBRAF mutation statusBRAF V600E mutationCentral LNM