2022
Blood-Based Biomarkers of Repetitive, Subconcussive Blast Overpressure Exposure in the Training Environment: A Pilot Study
Agoston D, McCullough J, Aniceto R, Lin I, Kamnaksh A, Eklund M, Graves W, Dunbar C, Engall J, Schneider E, Leonessa F, Duckworth J. Blood-Based Biomarkers of Repetitive, Subconcussive Blast Overpressure Exposure in the Training Environment: A Pilot Study. Neurotrauma Reports 2022, 3: 479-490. PMID: 36337080, PMCID: PMC9634979, DOI: 10.1089/neur.2022.0029.Peer-Reviewed Original ResearchTraumatic brain injuryMatrix metalloprotease-9Serum levelsClaudin-5Ubiquitin C-terminal hydrolase L1Pilot studyUnknown long-term effectsElevated autoantibody titersGlial fibrillary acidic proteinMild traumatic brain injuryElevated serum levelsBlood-based biomarkersAlpha 7 subunitChronic degenerative processMolecular changesFibrillary acidic proteinBlast overpressure exposureAutoantibody titersAutoimmune processVascular changesElevated titersBrain injuryLong-term effectsBlood samplesMetalloprotease-9837 Shunt-dependent Post Traumatic Hydrocephalus in Pediatric Patients with Moderate to Severe Traumatic Brain Injury (TBI)
Asemota A, Schneider E. 837 Shunt-dependent Post Traumatic Hydrocephalus in Pediatric Patients with Moderate to Severe Traumatic Brain Injury (TBI). Neurosurgery 2022, 68: 143-144. DOI: 10.1227/neu.0000000000001880_837.Peer-Reviewed Original ResearchPost-traumatic hydrocephalusTraumatic brain injuryVP shunt placementPediatric patientsBrain injuryHigher oddsMedian age 4 yearsNationwide Inpatient Sample 2000ICD-9-CM codesSevere traumatic brain injuryHigh inpatient morbidityPediatric TBI casesPediatric TBI patientsAcute respiratory failureMean patient ageAcute renal failureCongestive cardiac failureVentilator-Associated PneumoniaDeep vein thrombosisModerate-severe traumatic brain injuryMotor vehicle accidentsAge 4 yearsAge group categoriesMajority of casesTraumatic hydrocephalus
2018
Conscious status is associated with the likelihood of trauma centre care and mortality in patients with moderate-to-severe traumatic brain injury
AlSulaim H, Haring R, Asemota A, Smart B, Canner J, Ejaz A, Efron D, Velopulos C, Haut E, Schneider E. Conscious status is associated with the likelihood of trauma centre care and mortality in patients with moderate-to-severe traumatic brain injury. Brain Injury 2018, 32: 784-793. PMID: 29561720, DOI: 10.1080/02699052.2018.1451658.Peer-Reviewed Original ResearchConceptsLoss of consciousnessNon-trauma centersTraumatic brain injuryTrauma centerBrain injuryHead/neck Abbreviated Injury Scale scoreNeck Abbreviated Injury Scale scoreLevel I/II trauma centersAbbreviated Injury Scale scoreSevere traumatic brain injuryInjury Scale scoreOdds of mortalityTrauma center careTC treatmentLogistic regression modelsHospital mortalityOlder patientsPatient demographicsPrimary outcomeInjury characteristicsNinth RevisionAIS scoreTBI outcomesPrevention criteriaClinical Modification
2016
Burden of Pediatric Traumatic Brain Injury Beyond the Emergency Department: The Untold Story of the Silent Epidemic
Zogg C, Haring R, Canner J, AlSulaim H, Scully R, Wolf L, Engineer L, Haider A, Schneider E. Burden of Pediatric Traumatic Brain Injury Beyond the Emergency Department: The Untold Story of the Silent Epidemic. Journal Of The American College Of Surgeons 2016, 223: s158. DOI: 10.1016/j.jamcollsurg.2016.06.343.Peer-Reviewed Original ResearchThirty-day re-admission after traumatic brain injury: Results from MarketScan®
Canner J, Giuliano K, Gani F, Schneider E. Thirty-day re-admission after traumatic brain injury: Results from MarketScan®. Brain Injury 2016, 30: 1570-1575. PMID: 27589200, DOI: 10.1080/02699052.2016.1199898.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryPrimary diagnosisBrain injuryHead Abbreviated Injury ScoreCharacteristics of patientsCommon primary diagnosisAbbreviated Injury ScoreRe-admission ratesInpatient rehabilitation facilityIndex dischargeMore comorbiditiesConcurrent injuriesIndex hospitalizationInjury scoreDischarge planningThirty-dayRehabilitation facilityPsychiatric disordersGreater oddsPatientsElucidate causesAge 65InjuryDiagnosisMarketScanConscious status predicts mortality among patients with isolated traumatic brain injury in administrative data
Alsulaim H, Smart B, Asemota A, Haring R, Canner J, Efron D, Haut E, Schneider E. Conscious status predicts mortality among patients with isolated traumatic brain injury in administrative data. The American Journal Of Surgery 2016, 214: 207-210. PMID: 27663651, DOI: 10.1016/j.amjsurg.2016.07.012.Peer-Reviewed Original ResearchConceptsSevere TBIInjury severityMortality predictionNationwide Emergency Department SampleAdministrative dataEmergency Department SampleTraumatic brain injuryPrevention guidelinesInjury typeBrain injuryUnivariate analysisBrief lossInternational ClassificationOutcome studiesPhysiologic factorsPatientsConscious statusDisease controlLogistic regressionMortalityTBIAdministrative datasetsAnatomical measuresSimilar differencesMeeting CentersIntensity of treatment, end-of-life care, and mortality for older patients with severe traumatic brain injury
Lilley E, Williams K, Schneider E, Hammouda K, Salim A, Haider A, Cooper Z. Intensity of treatment, end-of-life care, and mortality for older patients with severe traumatic brain injury. Journal Of Trauma And Acute Care Surgery 2016, 80: 998-1004. PMID: 26953761, DOI: 10.1097/ta.0000000000001028.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryTraumatic brain injuryGeriatric patientsFunctional statusBrain injuryHospital mortality outcomesPatients 65 yearsDays of injuryGoals of careFurther aggressive treatmentSurgery of TraumaIntensity of treatmentHospital mortalityHospital deathLife decision makingAggressive treatmentHospital dischargeIdentifies patientsNeurologic statusNonresponder groupOlder patientsRetrospective reviewMortality outcomesPoor prognosisFunctional impairment
2015
Trends in incidence and severity of sports-related traumatic brain injury (TBI) in the emergency department, 2006–2011
Haring R, Canner J, Asemota A, George B, Selvarajah S, Haider A, Schneider E. Trends in incidence and severity of sports-related traumatic brain injury (TBI) in the emergency department, 2006–2011. Brain Injury 2015, 29: 989-992. PMID: 25962926, DOI: 10.3109/02699052.2015.1033014.Peer-Reviewed Original ResearchConceptsSports-related traumatic brain injuryTraumatic brain injuryEmergency departmentHospitalization ratesAbbreviated Injury Severity ScoreNationwide Emergency Department SampleInjury Severity ScoreEmergency Department SampleHigh school age groupsAbsolute annual numberSchool age groupED visitsPayer statusInpatient admissionsSeverity scoreBrain injuryMedical attentionInjury severityAge 65Age groupsYoung athletesAge 15Traumatic brain injury in the elderly: morbidity and mortality trends and risk factors
Haring R, Narang K, Canner J, Asemota A, George B, Selvarajah S, Haider A, Schneider E. Traumatic brain injury in the elderly: morbidity and mortality trends and risk factors. Journal Of Surgical Research 2015, 195: 1-9. PMID: 25724764, DOI: 10.1016/j.jss.2015.01.017.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryMechanism of injuryBrain injuryTBI-related deathsTBI-related hospitalizationOdds of deathMultivariable logistic regressionNationwide Inpatient SampleLogistic regression analysisOlder age groupsMore comorbiditiesMale patientsPayer statusTBI patientsInpatient SampleRisk factorsHigher oddsInjury severityPatientsMortality trendsAge groupsInjuryLogistic regressionTBI dataComorbidities
2014
Functional recovery after moderate/severe traumatic brain injury
Schneider E, Sur S, Raymont V, Duckworth J, Kowalski R, Efron D, Hui X, Selvarajah S, Hambridge H, Stevens R. Functional recovery after moderate/severe traumatic brain injury. Neurology 2014, 82: 1636-1642. PMID: 24759845, PMCID: PMC4211893, DOI: 10.1212/wnl.0000000000000379.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryTraumatic brain injuryYears of educationBrain injuryDisability Rating Scale scoresProspective multicenter cohortMain outcome measuresRating Scale scoresRobust independent predictorModel Systems databaseDose-response relationshipLogistic regression modelsTBI Model Systems databaseCognitive reserveIndependent predictorsMulticenter cohortPrognostic factorsFunctional recoveryRetrospective studyDuration of educationYears postinjuryOutcome measuresPatientsScale scoreNeural adaptationFaster is Better: Enhanced Enrollment in Public Insurance Programs Reduces Pediatric Mortality Following Traumatic Brain Injury
Cerullo M, Selvarajah S, Abdullah F, Lwin A, Kironji A, Britton B, Schneider E, Velopulos C, Pawlik T, Haider A. Faster is Better: Enhanced Enrollment in Public Insurance Programs Reduces Pediatric Mortality Following Traumatic Brain Injury. Journal Of Surgical Research 2014, 186: 518-519. DOI: 10.1016/j.jss.2013.11.351.Peer-Reviewed Original ResearchFaster is Better: Enhanced Enrollment in Public Insurance Programs Reduces Pediatric Mortality Following Traumatic Brain Injury
Cerullo M, Selvarajah S, Abdullah F, Lwin A, Kironji A, Britton B, Schneider E, Velopulos C, Pawlik T, Haider A. Faster is Better: Enhanced Enrollment in Public Insurance Programs Reduces Pediatric Mortality Following Traumatic Brain Injury. Journal Of Surgical Research 2014, 186: 521. DOI: 10.1016/j.jss.2013.11.359.Peer-Reviewed Original Research
2013
Race and Insurance Disparities in Discharge to Rehabilitation for Patients with Traumatic Brain Injury
Asemota A, George B, Cumpsty-Fowler C, Haider A, Schneider E. Race and Insurance Disparities in Discharge to Rehabilitation for Patients with Traumatic Brain Injury. Journal Of Neurotrauma 2013, 30: 2057-2065. PMID: 23972035, PMCID: PMC3868359, DOI: 10.1089/neu.2013.3091.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injurySevere traumatic brain injuryAdult TBI survivorsInsurance-based differencesOdds of dischargeHospital-level variablesImproved functional outcomesMeeting study criteriaMultivariable logistic regressionNationwide Inpatient SampleInpatient rehabilitation servicesInsurance-based disparitiesStandard descriptive methodsUninsured blacksUninsured HispanicsInpatient rehabilitationFunctional outcomeStudy criteriaInpatient SampleInsurance statusInpatient careTBI survivorsRehabilitation servicesLogistic regressionIncreased risk of pneumonia among ventilated patients with traumatic brain injury: every day counts!
Hui X, Haider A, Hashmi Z, Rushing A, Dhiman N, Scott V, Selvarajah S, Haut E, Efron D, Schneider E. Increased risk of pneumonia among ventilated patients with traumatic brain injury: every day counts! Journal Of Surgical Research 2013, 184: 438-443. PMID: 23816243, DOI: 10.1016/j.jss.2013.05.072.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryRisk of pneumoniaMechanical ventilationCause pneumoniaAIS scoreBrain injuryGlasgow Coma Scale motor scoreNational Trauma Data Bank 2007Days of MVICDMAP-90 softwareDevelopment of pneumoniaInjury Scale scoreScale motor scoreRisk of VAPApproximate relative riskVentilator independenceComorbidity scoreHospital lengthNeurologic impairmentMotor scoresVentilated patientsInjury factorsInsurance statusInjury typePneumonia casesCauses and Trends in Traumatic Brain Injury for United States Adolescents
Asemota A, George B, Bowman S, Haider A, Schneider E. Causes and Trends in Traumatic Brain Injury for United States Adolescents. Journal Of Neurotrauma 2013, 30: 67-75. PMID: 22989254, DOI: 10.1089/neu.2012.2605.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryAdolescent traumatic brain injuryYears age groupAge groupsUnited States adolescentsBrain injuryMost traumatic brain injuriesMotor vehicle occupant injuriesSevere traumatic brain injuryTBI-related hospitalizationOverall annual incidenceNationwide Inpatient SampleCause of injuryMotor vehicle accidentsYears old groupVehicle occupant injuriesMotor vehicle occupantsHospital mortalityTBI hospitalizationsAnnual incidenceInpatient SampleLeading causeCommon causeHospitalization dataHospitalization
2012
Epidemiology of moderate-to-severe penetrating versus closed traumatic brain injury in the Iraq and Afghanistan wars
Orman J, Geyer D, Jones J, Schneider E, Grafman J, Pugh M, DuBose J. Epidemiology of moderate-to-severe penetrating versus closed traumatic brain injury in the Iraq and Afghanistan wars. Journal Of Trauma And Acute Care Surgery 2012, 73: s496-s502. PMID: 23192076, DOI: 10.1097/ta.0b013e318275473c.Peer-Reviewed Original ResearchMeSH KeywordsAdultAfghan Campaign 2001-Age DistributionBrain InjuriesChi-Square DistributionFemaleHumansIncidenceInjury Severity ScoreIraq War, 2003-2011MaleMass Casualty IncidentsMiddle AgedPrognosisRegistriesRetrospective StudiesSex DistributionStatistics, NonparametricSurvival AnalysisUnited StatesWarfareWounds, NonpenetratingWounds, PenetratingYoung AdultConceptsClosed traumatic brain injuryTraumatic brain injuryBrain injuryInjury severityAbbreviated Injury Scale scoreSevere closed traumatic brain injuryCombat-related traumatic brain injuryJoint Theater Trauma RegistryInjury Scale scoreOverall injury severitySevere penetratingPatients meeting criteriaSevere brain injuryAnatomic injury severityTrauma registry dataMaximum Abbreviated Injury Scale scoreTrauma registrySurgical interventionSurveillance definitionsRegistry dataTBI severityEpidemiologic studiesNeck woundsMeeting criteriaScale scoreRegional variations in cost of trauma care in the United States
Obirieze A, Gaskin D, Villegas C, Bowman S, Schneider E, Oyetunji T, Haut E, Efron D, Cornwell E, Haider A. Regional variations in cost of trauma care in the United States. Journal Of Trauma And Acute Care Surgery 2012, 73: 516-522. PMID: 23019681, DOI: 10.1097/ta.0b013e31825132a0.Peer-Reviewed Original ResearchConceptsRelative mean costsTrauma careLiver injuryMean costModerate traumatic brain injuryPneumothorax/hemothoraxBlunt splenic injuryCharlson Comorbidity IndexClinical Modification codesNationwide Inpatient SampleLength of stayAdult trauma careTraumatic brain injuryCost of careMedical care costsIndex conditionComorbidity indexSplenic injuryHospital factorsPatient demographicsTrauma patientsTibia fracturesInpatient SampleBrain injuryInternational Classification