Does BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers
Li C, Han P, Lee K, Lee L, Fox A, Beninato T, Thiess M, Dy B, Sebo T, Thompson G, Grant C, Giordano T, Gauger P, Doherty G, Fahey T, Bishop J, Eshleman J, Umbricht C, Schneider E, Zeiger M. Does BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers. The Journal Of Clinical Endocrinology & Metabolism 2013, 98: 3702-3712. PMID: 23969188, DOI: 10.1210/jc.2013-1584.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionPapillary thyroid cancerClassical variant papillary thyroid cancerRoutine central lymph node dissectionEndocrine surgery centersBRAF mutationsIndependent predictorsMultivariable analysisAggressive featuresBRAF statusSurgery centersThyroid cancerProphylactic central lymph node dissectionBivariate analysisPresence of LNMLymph node dissectionAggressive clinicopathologic featuresTumor-related factorsAmerican Joint CommitteeLymph node metastasisTreatment of patientsBRAF mutation statusBRAF V600E mutationCentral LNM