Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion
Saunders LP, Ouellette A, Bandle R, Chang WC, Zhou H, Misra RN, De La Cruz EM, Braddock DT. Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Molecular Cancer Therapeutics 2008, 7: 3352-3362. PMID: 18852138, PMCID: PMC7857123, DOI: 10.1158/1535-7163.mct-08-0463.Peer-Reviewed Original ResearchConceptsSmall molecule inhibitorsMelanoma cell migrationLysophosphatidic acidCell migrationRecombinant human proteinsChemical screenHuman proteinsATX levelsMalignant melanomaMigratory phenotypeMelanoma cell linesHuman melanoma cellsRole of autotaxinInvasion assaysLPA productionCell growthImmunohistochemistry of paraffinMolecular targetsCell linesATX inhibitorsAutotaxinMelanoma cellsHuman malignanciesEnzymatic productHuman tissues