Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain
Altieri SL, Clayton GM, Silverman WR, Olivares AO, De La Cruz EM, Thomas LR, Morais-Cabral JH. Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain. Journal Of Molecular Biology 2008, 381: 655-669. PMID: 18619611, PMCID: PMC2555981, DOI: 10.1016/j.jmb.2008.06.011.Peer-Reviewed Original ResearchMeSH KeywordsCrystallography, X-RayCyclic AMPCyclic GMPCyclic Nucleotide-Gated Cation ChannelsHydrophobic and Hydrophilic InteractionsModels, MolecularMutationNucleotides, CyclicProtein BindingProtein ConformationProtein Structure, TertiaryConceptsBinding domainsCyclic Nucleotide Binding DomainLigand bindingC-terminal cyclicNucleotide-dependent proteinNucleotide Binding DomainAbsence of ligandFull-length channelLigand-protein interactionsCNB domainsUseful model systemProkaryotic homologResidue side chainsApo stateDependent ion channelsApo configurationsSingle proteinMlotiK1Domain fragmentNucleotide selectivityIon channelsDomain structureX-ray crystallographyX-ray structureModel system