2019
Plastic Deformation and Fragmentation of Strained Actin Filaments
Schramm AC, Hocky GM, Voth GA, Martiel JL, De La Cruz EM. Plastic Deformation and Fragmentation of Strained Actin Filaments. Biophysical Journal 2019, 117: 453-463. PMID: 31301801, PMCID: PMC6697348, DOI: 10.1016/j.bpj.2019.06.018.Peer-Reviewed Original Research
2015
Actin Mechanics and Fragmentation*
De La Cruz EM, Gardel ML. Actin Mechanics and Fragmentation*. Journal Of Biological Chemistry 2015, 290: 17137-17144. PMID: 25957404, PMCID: PMC4498053, DOI: 10.1074/jbc.r115.636472.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonActinsAnimalsBiomechanical PhenomenaHumansModels, MolecularProtein Structure, TertiaryMechanical Heterogeneity Favors Fragmentation of Strained Actin Filaments
De La Cruz EM, Martiel JL, Blanchoin L. Mechanical Heterogeneity Favors Fragmentation of Strained Actin Filaments. Biophysical Journal 2015, 108: 2270-2281. PMID: 25954884, PMCID: PMC4423049, DOI: 10.1016/j.bpj.2015.03.058.Peer-Reviewed Original ResearchConceptsMechanical propertiesFilament deformationEnergy densityElastic energyLocal shear forcesDeformation modesFilament strainFilament mechanical propertiesCompliant segmentsMechanical heterogeneityCompressive forceShear forceDeformationFree energy densityElastic free energy densityTwisting rigiditiesShape deformationLocal discontinuitiesSpatial confinementElasticitySevering efficiencyEnergyEnergy gradientConfinementForce
2014
Multi-Platform Compatible Software for Analysis of Polymer Bending Mechanics
Graham JS, McCullough BR, Kang H, Elam WA, Cao W, De La Cruz EM. Multi-Platform Compatible Software for Analysis of Polymer Bending Mechanics. PLOS ONE 2014, 9: e94766. PMID: 24740323, PMCID: PMC3989245, DOI: 10.1371/journal.pone.0094766.Peer-Reviewed Original Research
2012
Identification of cation-binding sites on actin that drive polymerization and modulate bending stiffness
Kang H, Bradley MJ, McCullough BR, Pierre A, Grintsevich EE, Reisler E, De La Cruz EM. Identification of cation-binding sites on actin that drive polymerization and modulate bending stiffness. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16923-16927. PMID: 23027950, PMCID: PMC3479481, DOI: 10.1073/pnas.1211078109.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino AcidsAnimalsBiomechanical PhenomenaCationsComputational BiologyFluorescenceModels, MolecularPolymerizationRabbitsThermodynamicsConceptsCation-binding sitesActin assemblyEukaryotic biologyLong-pitch helixActin functionSalt-dependent effectsCell divisionCell motilityActin polymerizationFilament assemblyAdjacent subunitsIntracellular transportActin filamentsPhysiological salt concentrationsActin monomersCellular shapeNonspecific ionic strength effectsDiscrete sites
2011
Direct Observation of the Myosin Va Recovery Stroke That Contributes to Unidirectional Stepping along Actin
Shiroguchi K, Chin HF, Hannemann DE, Muneyuki E, De La Cruz EM, Kinosita K. Direct Observation of the Myosin Va Recovery Stroke That Contributes to Unidirectional Stepping along Actin. PLOS Biology 2011, 9: e1001031. PMID: 21532738, PMCID: PMC3075224, DOI: 10.1371/journal.pbio.1001031.Peer-Reviewed Original Research
2010
Origin of Twist-Bend Coupling in Actin Filaments
De La Cruz EM, Roland J, McCullough BR, Blanchoin L, Martiel JL. Origin of Twist-Bend Coupling in Actin Filaments. Biophysical Journal 2010, 99: 1852-1860. PMID: 20858430, PMCID: PMC2941021, DOI: 10.1016/j.bpj.2010.07.009.Peer-Reviewed Original ResearchActin CytoskeletonBiomechanical PhenomenaElasticityModels, MolecularMolecular ConformationRotationThermodynamics
2008
Cofilin Increases the Bending Flexibility of Actin Filaments: Implications for Severing and Cell Mechanics
McCullough BR, Blanchoin L, Martiel JL, De La Cruz EM. Cofilin Increases the Bending Flexibility of Actin Filaments: Implications for Severing and Cell Mechanics. Journal Of Molecular Biology 2008, 381: 550-558. PMID: 18617188, PMCID: PMC2753234, DOI: 10.1016/j.jmb.2008.05.055.Peer-Reviewed Original Research