2020
Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering
Stabach PR, Zimmerman K, Adame A, Kavanagh D, Saeui CT, Agatemor C, Gray S, Cao W, De La Cruz EM, Yarema KJ, Braddock DT. Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering. Clinical And Translational Science 2020, 14: 362-372. PMID: 33064927, PMCID: PMC7877847, DOI: 10.1111/cts.12887.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArea Under CurveDisease Models, AnimalEnzyme Replacement TherapyGlycosylationHalf-LifeHistocompatibility Antigens Class IHumansMaleMice, TransgenicPhosphoric Diester HydrolasesProtein EngineeringProtein Structure, TertiaryPyrophosphatasesReceptors, FcRecombinant Fusion ProteinsVascular CalcificationConceptsProtein engineeringO-BuN-glycansGlycosylation engineeringCellular recyclingENPP1-deficient miceTerminal sialylationBiomanufacturing platformProtein therapeuticsCalcification disordersSialylationCellsVivo activityFc neonatal receptorTherapeuticsArterial calcificationProteinMurine modelManNAcEnzyme replacementNeonatal receptorEfficacious levelsGeneral strategyThree-prong strategyDrug potency
2015
Actin Mechanics and Fragmentation*
De La Cruz EM, Gardel ML. Actin Mechanics and Fragmentation*. Journal Of Biological Chemistry 2015, 290: 17137-17144. PMID: 25957404, PMCID: PMC4498053, DOI: 10.1074/jbc.r115.636472.Peer-Reviewed Original Research
2008
The Roles of Thymosin β4 in Cell Migration and Cell-to-Cell Signaling in Disease
Au J, Krendel M, Safer D, De La Cruz E. The Roles of Thymosin β4 in Cell Migration and Cell-to-Cell Signaling in Disease. Protein Reviews 2008, 218-228. DOI: 10.1007/978-0-387-71749-4_9.Peer-Reviewed Original ResearchΒ-thymosinsMetazoan cellsExtracellular cuesCell signalingFree actin monomersFilament elongationMonomeric actinActin monomersCell migrationInduction of angiogenesisRegulatory effectsTumor metastasisThymosin β4CellsTherapeutic applicationsSignalingPolypeptideActinΒ4High concentrationsAngiogenesisInductionFamilyComplexesTβ4
2001
Actin-Binding Proteins: An Overview
De La Cruz E. Actin-Binding Proteins: An Overview. Results And Problems In Cell Differentiation 2001, 32: 123-134. PMID: 11131827, DOI: 10.1007/978-3-540-46560-7_9.Peer-Reviewed Original Research