Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion
Saunders LP, Ouellette A, Bandle R, Chang WC, Zhou H, Misra RN, De La Cruz EM, Braddock DT. Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Molecular Cancer Therapeutics 2008, 7: 3352-3362. PMID: 18852138, PMCID: PMC7857123, DOI: 10.1158/1535-7163.mct-08-0463.Peer-Reviewed Original ResearchConceptsSmall molecule inhibitorsMelanoma cell migrationLysophosphatidic acidCell migrationRecombinant human proteinsChemical screenHuman proteinsATX levelsMalignant melanomaMigratory phenotypeMelanoma cell linesHuman melanoma cellsRole of autotaxinInvasion assaysLPA productionCell growthImmunohistochemistry of paraffinMolecular targetsCell linesATX inhibitorsAutotaxinMelanoma cellsHuman malignanciesEnzymatic productHuman tissuesThe Roles of Thymosin β4 in Cell Migration and Cell-to-Cell Signaling in Disease
Au J, Krendel M, Safer D, De La Cruz E. The Roles of Thymosin β4 in Cell Migration and Cell-to-Cell Signaling in Disease. Protein Reviews 2008, 218-228. DOI: 10.1007/978-0-387-71749-4_9.Peer-Reviewed Original ResearchΒ-thymosinsMetazoan cellsExtracellular cuesCell signalingFree actin monomersFilament elongationMonomeric actinActin monomersCell migrationInduction of angiogenesisRegulatory effectsTumor metastasisThymosin β4CellsTherapeutic applicationsSignalingPolypeptideActinΒ4High concentrationsAngiogenesisInductionFamilyComplexesTβ4