2024
Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York
Anuforo A, Aneni E, Akintoye E, Anikpezie N, Patel S, Soipe A, Olojakpoke E, Burke D, Latorre J, Khandelwal P, Chaturvedi S, Ovbiagele B, Otite F. Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York. Circulation 2024, 149: 1391-1393. PMID: 38648273, DOI: 10.1161/circulationaha.123.066921.Peer-Reviewed Original Research
2023
Imaging biomarkers in aortic valve disease: it is time to shift the focus to the myocardium
Kwon D, Akintoye E. Imaging biomarkers in aortic valve disease: it is time to shift the focus to the myocardium. European Heart Journal - Cardiovascular Imaging 2023, 24: 863-865. PMID: 37220177, DOI: 10.1093/ehjci/jead095.Peer-Reviewed Original ResearchPrognostic Utility of Left Atrial Strain to Predict Thrombotic Events and Mortality in Amyloid Cardiomyopathy
Akintoye E, Majid M, Klein A, Hanna M. Prognostic Utility of Left Atrial Strain to Predict Thrombotic Events and Mortality in Amyloid Cardiomyopathy. JACC Cardiovascular Imaging 2023, 16: 1371-1383. PMID: 37940322, DOI: 10.1016/j.jcmg.2023.01.015.Peer-Reviewed Original ResearchConceptsThrombotic eventsAmyloid cardiomyopathyAtrial fibrillationLA contractileLA strainLA contractile strainModest discriminatory abilityPrognostic staging systemRisk stratification toolLeft Atrial StrainHigh thrombotic riskAtrial strainPrognostic utilityStratification toolPrognostic valueC-statisticRespective HRsStaging systemThrombotic riskACM patientsSD decreaseAF casesPredictive valuePatientsDiscriminatory abilityImpact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Akintoye E, Saijo Y, Braghieri L, Badwan O, Patel H, Dabbagh M, El Dahdah J, Jellis C, Desai M, Rodriguez L, Grimm R, Griffin B, Popović Z. Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. Journal Of The American College Of Cardiology 2023, 81: 1474-1487. PMID: 37045517, DOI: 10.1016/j.jacc.2023.02.037.Peer-Reviewed Original ResearchConceptsSmaller LV volumesAdverse eventsAortic regurgitationBody surface areaOlder patientsYounger patientsLV volumesImpact of ageLV remodelingSerial evaluationLV end-systolic volumeLV end-diastolic volumeSevere aortic regurgitationChronic aortic regurgitationLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volumeLower LV volumesAdult patientsConsecutive patientsMain endpointVentricular dimensionsVentricular remodelingCurrent guidelinesPatientsLeft Ventricular Global Longitudinal Strain Before TAVR Time to Jump the Ejection Fraction Ship? ∗
Desai M, Akintoye E. Left Ventricular Global Longitudinal Strain Before TAVR Time to Jump the Ejection Fraction Ship? ∗. JACC Cardiovascular Imaging 2023, 16: 342-344. PMID: 36889850, DOI: 10.1016/j.jcmg.2023.01.011.Peer-Reviewed Original ResearchEcho Doppler Parameters of Diastolic Function
Anthony C, Akintoye E, Wang T, Klein A. Echo Doppler Parameters of Diastolic Function. Current Cardiology Reports 2023, 25: 235-247. PMID: 36821063, DOI: 10.1007/s11886-023-01844-3.Peer-Reviewed Original ResearchConceptsDiastolic dysfunctionEcho-Doppler parametersDiastolic functionDoppler parametersEvaluation of DDAbnormal diastolic functionDoppler echocardiography techniquesLV filling pressureModest diagnostic performanceSignificant inter-observer variabilityEchocardiographic parametersRecent guidelinesAppropriate diagnosisFilling pressureInvasive measuresReviewThe purposeEchocardiography techniquesInter-observer variabilityEuropean AssociationCardiovascular imagingDiagnostic performanceEchocardiographyAmerican SocietyGuideline documentsDiagnosisAtrial Functional Tricuspid Regurgitation Do We Blame the AF, Right Atrium, or Both? ∗
Wang T, Akintoye E. Atrial Functional Tricuspid Regurgitation Do We Blame the AF, Right Atrium, or Both? ∗. JACC Cardiovascular Imaging 2023, 16: 588-590. PMID: 36752438, DOI: 10.1016/j.jcmg.2022.12.007.Peer-Reviewed Original Research
2022
Clinical outcomes and 30-day readmissions associated with high-output heart failure
Uddin M, Mir T, Briasoulis A, Akintoye E, Adegbala O, Shafi I, Qureshi W, Afonso L. Clinical outcomes and 30-day readmissions associated with high-output heart failure. Hellenic Journal Of Cardiology 2022, 69: 24-30. PMID: 36273803, DOI: 10.1016/j.hjc.2022.10.004.Peer-Reviewed Original ResearchConceptsHigh-output heart failureNational Readmission DatabaseHeart failureMyelodysplastic syndromeHealthcare costsUtilization Project National Readmission DatabaseLow systemic vascular resistanceReduced ejection fractionSystemic vascular resistanceHigh cardiac outputQuality's Healthcare CostSickle cell diseaseHospital mortalityNoncardiovascular disordersUnderdiagnosed typeCardiovascular complicationsMorbid obesityVascular resistanceHematological complicationsReadmission ratesEjection fractionPulmonary diseaseClinical outcomesCardiac outputDiagnostic codesQuantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation
Akintoye E, Wang T, Nakhla M, Ali A, Fava A, Akyuz K, Popovic Z, Pettersson G, Gillinov A, Xu B, Griffin B, Desai M. Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation. JACC Cardiovascular Imaging 2022, 16: 13-24. PMID: 36274042, DOI: 10.1016/j.jcmg.2022.08.004.Peer-Reviewed Original ResearchConceptsTricuspid regurgitationMedian survival timeRisk factorsAsymptomatic patientsEchocardiographic parametersSurvival timeEarly interventionOptimal timingRight heart parametersSymptomatic tricuspid regurgitationSignificant tricuspid regurgitationFree wall strainHigh operative mortalitySex-matched cohortQuantitative echocardiographic assessmentKey prognostic markersCause mortalityOperative mortalityTR patientsEchocardiographic assessmentLate presentationPoor outcomePrognostic utilityPrognostic valuePrognostic markerDynamic Pulmonary Vein Stenosis—Utility of Multimodality Imaging and Invasive Assessment
Akintoye E, Renapurkar R, Hughes D, Kapadia S, Harb S. Dynamic Pulmonary Vein Stenosis—Utility of Multimodality Imaging and Invasive Assessment. Circulation Cardiovascular Imaging 2022, 15: e014318. PMID: 36172857, DOI: 10.1161/circimaging.122.014318.Peer-Reviewed Original ResearchTrends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation
Akintoye E, Salih M, Aje K, Alvarez P, Sellke F, Briasoulis A, Dorbala S. Trends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation. Canadian Journal Of Cardiology 2022, 38: 1263-1270. PMID: 35525397, DOI: 10.1016/j.cjca.2022.04.023.Peer-Reviewed Original ResearchConceptsHeart transplantGraft survivalAmyloid cardiomyopathyWaitlist mortalityHeart transplantationRisk factorsSingle-organ heart transplantsStudy periodHeart transplant waitlistUnderwent heart transplantWorse graft survivalGraft survival ratesOutcomes of patientsPropensity-matched cohortOrgan Sharing databaseHigher waitlist mortalityNumber of patientsNumber of transplantsAmyloid recurrenceAdult patientsGraft failureRenal failureIndependent predictorsSharing databaseUnited NetworkClinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation
Layoun H, Mentias A, Akintoye E, Matta M, Kanaan C, Daou R, Ramchand J, Burns D, Gillinov A, Bhattacharya S, Puri R, Collier P, Griffin B, Kapadia S, Harb S. Clinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation. Open Heart 2022, 9: e001996. PMID: 35383126, PMCID: PMC8984044, DOI: 10.1136/openhrt-2022-001996.Peer-Reviewed Original ResearchConceptsSecondary mitral regurgitationAtrial dilationMitral regurgitationPrognostic implicationsSevere left atrial dilationSevere secondary mitral regurgitationLA reservoir strainLeft atrial dilationLeft ventricle dysfunctionPoor prognostic indicatorMV interventionVentricle dysfunctionMore diabetesAdult patientsTransthoracic echocardiographyEjection fractionIndependent predictorsAtrial fibrillationReservoir strainWorse prognosisPrognostic indicatorMR severityBetter outcomesFunctional alterationsPatientsImpact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database
Khalil M, Maraey A, Aglan A, Akintoye E, Salem M, Elzanaty A, Younes A, Saeyeldin A, Barbhaiya C, Shokr M. Impact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database. Journal Of Interventional Cardiac Electrophysiology 2022, 66: 323-331. PMID: 35314904, DOI: 10.1007/s10840-022-01187-z.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseNational Readmission DatabaseClinical outcomesVentricular tachycardiaCatheter ablationKidney diseaseHospital mortalityVT ablationOdds ratioCorresponding diagnosis codesUnderwent catheter ablationAcute kidney injuryTotal hospital chargesWorse clinical outcomesMean lengthMultivariable regression analysisCKD groupConclusionIn patientsGroup patientsKidney injurySecondary outcomesHospital chargesDiagnosis codesClinical dataEffective treatmentOutcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis
Akintoye E, Alvarez P, Salih M, Sellke F, Briasoulis A. Outcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis. Clinical Transplantation 2022, 36: e14590. PMID: 35018661, DOI: 10.1111/ctr.14590.Peer-Reviewed Original ResearchConceptsDiabetic patientsWaitlist mortalityHeart transplantPost-transplant graft survivalEnd-stage heart failurePropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureHeart failureUnited NetworkRisk factorsOrgan SharingPatientsStudy periodTransplantMortalityFailureCohortWaitlistRilonacept for the treatment of recurrent pericarditis
Fava A, Reyaldeen R, Presti S, Goyal A, Akintoye E, Hughes D, Klein A. Rilonacept for the treatment of recurrent pericarditis. Expert Opinion On Biological Therapy 2022, 22: 7-16. PMID: 34757872, DOI: 10.1080/14712598.2022.2005024.Peer-Reviewed Original ResearchConceptsRecurrent pericarditisC-reactive proteinClinical trialsUpper respiratory tract infectionSafety of rilonaceptCommon adverse eventsRespiratory tract infectionsAvailable clinical trialsInjection site reactionsRapid clinical responseValuable therapeutic optionGood safety profilePromising new therapyIL-1β signalingDimeric fusion proteinGlucocorticoid-dependent diseasesAdverse eventsClinical responseTherapy durationTract infectionsSuccessful weaningRecurrence rateSafety profileTherapeutic optionsFuture trials
2021
Changing Demographics, Temporal Trends in Waitlist, and Posttransplant Outcomes After Heart Transplantation in the United States: Analysis of the UNOS Database 1991–2019
Akintoye E, Alvarez P, Shin D, Egbe A, Panos A, Sellke F, Briasoulis A. Changing Demographics, Temporal Trends in Waitlist, and Posttransplant Outcomes After Heart Transplantation in the United States: Analysis of the UNOS Database 1991–2019. Circulation Heart Failure 2021, 14: e008764. PMID: 34689572, DOI: 10.1161/circheartfailure.121.008764.Peer-Reviewed Original ResearchConceptsHeart transplantationPosttransplant outcomesPatient characteristicsHigh-risk comorbiditiesCharacteristics of patientsShort-term survivalRisk comorbiditiesHospital strokeWaitlist mortalityRenal failureUnited NetworkTransplant volumeEra 1Organ SharingPatientsTransplantationWaitlistEra 4Study periodTime pointsSignificant decreaseTemporal trendsOutcomesSignificant changesUnited StatesPrognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices
Ali A, Akintoye E, Duque E, Kshetri R, Shetty S, Sharma U, Johnson C, Panos A, Briasoulis A, Alvarez P. Prognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices. ASAIO Journal 2021, 68: 524-530. PMID: 34352812, DOI: 10.1097/mat.0000000000001524.Peer-Reviewed Original ResearchConceptsNT-pro BNP concentrationHF hospitalizationBNP concentrationsVentricular assist devicePrognostic implicationsN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideAssist deviceHeart failure hospitalizationNT-pro BNPFailure hospitalizationIndex hospitalizationAdverse eventsLVAD implantationConsecutive patientsAmbulatory patientsNatriuretic peptideRetrospective studyHospitalizationAmbulatory settingPatientsMonth baselineMonthsDeathUnit increasePrognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts
Akintoye E, Afonso L, Jayanna M, Bao W, Briasoulis A, Robinson J. Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts. Journal Of The American Heart Association 2021, 10: e019589. PMID: 34092110, PMCID: PMC8477885, DOI: 10.1161/jaha.120.019589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationBiomarkersCardiovascular DiseasesCholesterolClinical Decision-MakingCoronary Artery DiseaseDecision Support TechniquesDyslipidemiasFemaleHeart Disease Risk FactorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedPractice Guidelines as TopicPredictive Value of TestsPrimary PreventionPrognosisRisk AssessmentTime FactorsUnited StatesVascular CalcificationConceptsPooled Cohort EquationsCoronary artery calcium scoreCholesterol treatment guidelinesArtery calcium scoreAtherosclerotic cardiovascular diseaseCohort EquationsRisk enhancersCalcium scoreTreatment guidelinesCardiovascular diseaseAmerican Heart Association/American CollegeAtherosclerotic cardiovascular disease eventsBackground Limited dataIntermediate-risk participantsIntermediate-risk patientsCardiovascular disease eventsLarge prospective cohortIncremental valueNet reclassification indexStatin therapyCAC testingProspective cohortPrognostic utilityC-statisticReclassification indexTop ten takeaways from #ASNC2020: FITs’ perspective
Shetty M, Akintoye E. Top ten takeaways from #ASNC2020: FITs’ perspective. Journal Of Nuclear Cardiology 2021, 28: 1068-1071. PMID: 33655446, DOI: 10.1007/s12350-021-02559-0.Peer-Reviewed Original ResearchLongitudinal trends and outcomes of adult heart transplantation in the U.S.
Akintoye E, Asleh R, Alvarez P, Briasoulis A. Longitudinal trends and outcomes of adult heart transplantation in the U.S. European Journal Of Internal Medicine 2021, 86: 115-117. PMID: 33495082, DOI: 10.1016/j.ejim.2021.01.001.Peer-Reviewed Original Research