2024
Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York
Anuforo A, Aneni E, Akintoye E, Anikpezie N, Patel S, Soipe A, Olojakpoke E, Burke D, Latorre J, Khandelwal P, Chaturvedi S, Ovbiagele B, Otite F. Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York. Circulation 2024, 149: 1391-1393. PMID: 38648273, DOI: 10.1161/circulationaha.123.066921.Peer-Reviewed Original Research
2023
Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Akintoye E, Saijo Y, Braghieri L, Badwan O, Patel H, Dabbagh M, El Dahdah J, Jellis C, Desai M, Rodriguez L, Grimm R, Griffin B, Popović Z. Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. Journal Of The American College Of Cardiology 2023, 81: 1474-1487. PMID: 37045517, DOI: 10.1016/j.jacc.2023.02.037.Peer-Reviewed Original ResearchConceptsSmaller LV volumesAdverse eventsAortic regurgitationBody surface areaOlder patientsYounger patientsLV volumesImpact of ageLV remodelingSerial evaluationLV end-systolic volumeLV end-diastolic volumeSevere aortic regurgitationChronic aortic regurgitationLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volumeLower LV volumesAdult patientsConsecutive patientsMain endpointVentricular dimensionsVentricular remodelingCurrent guidelinesPatients
2022
Clinical outcomes and 30-day readmissions associated with high-output heart failure
Uddin M, Mir T, Briasoulis A, Akintoye E, Adegbala O, Shafi I, Qureshi W, Afonso L. Clinical outcomes and 30-day readmissions associated with high-output heart failure. Hellenic Journal Of Cardiology 2022, 69: 24-30. PMID: 36273803, DOI: 10.1016/j.hjc.2022.10.004.Peer-Reviewed Original ResearchConceptsHigh-output heart failureNational Readmission DatabaseHeart failureMyelodysplastic syndromeHealthcare costsUtilization Project National Readmission DatabaseLow systemic vascular resistanceReduced ejection fractionSystemic vascular resistanceHigh cardiac outputQuality's Healthcare CostSickle cell diseaseHospital mortalityNoncardiovascular disordersUnderdiagnosed typeCardiovascular complicationsMorbid obesityVascular resistanceHematological complicationsReadmission ratesEjection fractionPulmonary diseaseClinical outcomesCardiac outputDiagnostic codesQuantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation
Akintoye E, Wang T, Nakhla M, Ali A, Fava A, Akyuz K, Popovic Z, Pettersson G, Gillinov A, Xu B, Griffin B, Desai M. Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation. JACC Cardiovascular Imaging 2022, 16: 13-24. PMID: 36274042, DOI: 10.1016/j.jcmg.2022.08.004.Peer-Reviewed Original ResearchConceptsTricuspid regurgitationMedian survival timeRisk factorsAsymptomatic patientsEchocardiographic parametersSurvival timeEarly interventionOptimal timingRight heart parametersSymptomatic tricuspid regurgitationSignificant tricuspid regurgitationFree wall strainHigh operative mortalitySex-matched cohortQuantitative echocardiographic assessmentKey prognostic markersCause mortalityOperative mortalityTR patientsEchocardiographic assessmentLate presentationPoor outcomePrognostic utilityPrognostic valuePrognostic markerImpact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database
Khalil M, Maraey A, Aglan A, Akintoye E, Salem M, Elzanaty A, Younes A, Saeyeldin A, Barbhaiya C, Shokr M. Impact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database. Journal Of Interventional Cardiac Electrophysiology 2022, 66: 323-331. PMID: 35314904, DOI: 10.1007/s10840-022-01187-z.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseNational Readmission DatabaseClinical outcomesVentricular tachycardiaCatheter ablationKidney diseaseHospital mortalityVT ablationOdds ratioCorresponding diagnosis codesUnderwent catheter ablationAcute kidney injuryTotal hospital chargesWorse clinical outcomesMean lengthMultivariable regression analysisCKD groupConclusionIn patientsGroup patientsKidney injurySecondary outcomesHospital chargesDiagnosis codesClinical dataEffective treatment
2021
Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts
Akintoye E, Afonso L, Jayanna M, Bao W, Briasoulis A, Robinson J. Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts. Journal Of The American Heart Association 2021, 10: e019589. PMID: 34092110, PMCID: PMC8477885, DOI: 10.1161/jaha.120.019589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationBiomarkersCardiovascular DiseasesCholesterolClinical Decision-MakingCoronary Artery DiseaseDecision Support TechniquesDyslipidemiasFemaleHeart Disease Risk FactorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedPractice Guidelines as TopicPredictive Value of TestsPrimary PreventionPrognosisRisk AssessmentTime FactorsUnited StatesVascular CalcificationConceptsPooled Cohort EquationsCoronary artery calcium scoreCholesterol treatment guidelinesArtery calcium scoreAtherosclerotic cardiovascular diseaseCohort EquationsRisk enhancersCalcium scoreTreatment guidelinesCardiovascular diseaseAmerican Heart Association/American CollegeAtherosclerotic cardiovascular disease eventsBackground Limited dataIntermediate-risk participantsIntermediate-risk patientsCardiovascular disease eventsLarge prospective cohortIncremental valueNet reclassification indexStatin therapyCAC testingProspective cohortPrognostic utilityC-statisticReclassification index
2020
Aortic Valve Replacement for Severe Aortic Stenosis Before and During the Era of Transcatheter Aortic Valve Implantation
Akintoye E, Ando T, Sandio A, Adegbala O, Salih M, Zubairu J, Oseni A, Sistla P, Alqasrawi M, Egbe A, Mentias A, Afonso L, Briasoulis A, Panaich S, Desai M. Aortic Valve Replacement for Severe Aortic Stenosis Before and During the Era of Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2020, 126: 73-81. PMID: 32336533, DOI: 10.1016/j.amjcard.2020.03.038.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisAortic valve replacementNational Inpatient SampleTAVI eraAortic stenosisMean annual changeValve replacementFavorable short-term outcomesTranscatheter aortic valve replacementTranscatheter aortic valve implantationRate of AVRAcute kidney injuryRate of strokeAortic valve implantationShort-term outcomesRisk-adjusted ratesHospital mortalityPre-TAVIHospital outcomesKidney injuryHome dischargeHospital dischargePacemaker implantationValve implantationMedian lengthPalliative Care in Ruptured Aortic Aneurysm in the United States: A Retrospective Analysis of Nationwide Inpatient Sample Database
Ando T, Adegbala O, Uemura T, Ashraf S, Akintoye E, Pahuja M, Afonso L, Briasoulis A, Takagi H. Palliative Care in Ruptured Aortic Aneurysm in the United States: A Retrospective Analysis of Nationwide Inpatient Sample Database. Angiology 2020, 71: 633-640. PMID: 32249588, DOI: 10.1177/0003319720917239.Peer-Reviewed Original ResearchConceptsLength of stayHospitalization costsPalliative careAortic aneurysmRepair groupNationwide Inpatient Sample databasePalliative care referralPC referral ratePercutaneous repair groupRuptured Aortic AneurysmSurgical repair groupNationwide Inpatient SamplePC referralCare referralInpatient SampleReferral ratesRetrospective analysisAdmissionStudy periodSample databaseFurther studiesStayAneurysmsReferralCareRural–Urban Disparities in Intracerebral Hemorrhage Mortality in the USA: Preliminary Findings from the National Inpatient Sample
Otite F, Akano E, Akintoye E, Khandelwal P, Malik A, Chaturvedi S, Rosand J. Rural–Urban Disparities in Intracerebral Hemorrhage Mortality in the USA: Preliminary Findings from the National Inpatient Sample. Neurocritical Care 2020, 32: 715-724. PMID: 32232726, PMCID: PMC7223184, DOI: 10.1007/s12028-020-00950-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAphasiaCerebral HemorrhageComorbidityCraniotomyDeglutition DisordersFemaleHealthcare DisparitiesHospital Bed CapacityHospital MortalityHospitals, RuralHospitals, UrbanHumansHydrocephalusMaleMiddle AgedRespiration, ArtificialRisk FactorsUnited StatesYoung AdultConceptsNational Inpatient SampleSex-adjusted mortalityUrban hospitalRural hospitalsICH patientsInpatient SampleJoinpoint regressionIntracerebral hemorrhage mortalityMultivariable-adjusted modelsOdds of mortalityIntracerebral hemorrhage patientsCases of ICHHospital deathHospital mortalityMultivariable adjustmentUrban patientsRural patientsStroke careHemorrhage patientsMedicare insuranceRural-urban disparitiesPatientsResultsFrom 2004HospitalMortality gapThe impact of insurance type on listing status and wait‐list mortality of patients with left ventricular assist devices as bridge to transplantation
Briasoulis A, Akintoye E, Inampudi C, Hammoud A, Alvarez P. The impact of insurance type on listing status and wait‐list mortality of patients with left ventricular assist devices as bridge to transplantation. ESC Heart Failure 2020, 7: 804-810. PMID: 32135039, PMCID: PMC7261523, DOI: 10.1002/ehf2.12655.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceInsurance typeVentricular assist deviceTime of listingWaiting listAssist deviceHeart transplantation candidatesOrgan Sharing registryWait-list mortalityRisk regression analysisDifferent insurance typesAdequate health insurance coverageHealth insurance coverageStatus 1APublic health insuranceCumulative incidenceTransplantation candidatesTransplantation ratesUnited NetworkPost-HTMA patientsType of insurancePatientsMortalityCumulative mortalityAssociation between Hospital volume of cardiopulmonary resuscitation for in-hospital cardiac arrest and survival to Hospital discharge
Akintoye E, Adegbala O, Egbe A, Olawusi E, Afonso L, Briasoulis A. Association between Hospital volume of cardiopulmonary resuscitation for in-hospital cardiac arrest and survival to Hospital discharge. Resuscitation 2020, 148: 25-31. PMID: 31945429, DOI: 10.1016/j.resuscitation.2019.12.037.Peer-Reviewed Original ResearchConceptsNational Inpatient SampleHospital cardiac arrestHospital dischargeCase volumeCardiac arrestCases of IHCAHospital case volumeMedian case volumeNon-significant trendNon-linear associationHospital volumeHome dischargeHospital CPRYounger patientsInpatient SampleCardiopulmonary resuscitationHigh comorbidityBetter survivalFirst quartileIHCAHospitalQuartilePatientsStudy periodSurvival
2019
Palliative care referral in ST-segment elevation myocardial infarction complicated with cardiogenic shock in the United States
Ando T, Akintoye E, Uemura T, Adegbala O, Ashraf S, Pahuja M, Shokr M, Takagi H, Grines C, Afonso L, Briasoulis A. Palliative care referral in ST-segment elevation myocardial infarction complicated with cardiogenic shock in the United States. Heart & Lung 2019, 49: 25-29. PMID: 31703953, DOI: 10.1016/j.hrtlng.2019.10.005.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPalliative care referralElevation myocardial infarctionPC referralSTEMI-CSCardiogenic shockCare referralMyocardial infarctionMechanical circulatory support useCoronary artery bypass graftStudy periodPC referral rateArtery bypass graftExtended care facilitiesNationwide Inpatient SampleEdition Clinical ModificationTrends of utilizationLow-income statusPC encountersPC consultationBypass graftMultivariable analysisInpatient SampleReferral ratesHigh comorbidityClinical and economic burden of heparin-induced thrombocytopenia in hospitalized patients undergoing percutaneous peripheral arterial interventions
Subahi A, Osman M, Adegbala O, Abubakar H, Kheiri B, Yassin A, Khalid M, Akintoye E, Eljack A, Osman K, Alkhouli M. Clinical and economic burden of heparin-induced thrombocytopenia in hospitalized patients undergoing percutaneous peripheral arterial interventions. Vascular 2019, 28: 81-86. PMID: 31382836, DOI: 10.1177/1708538119868615.Peer-Reviewed Original ResearchConceptsVenous thrombosis/pulmonary embolismAcute kidney injuryKidney injuryIschemic strokePulmonary embolismHigh riskDeep venous thrombosis/pulmonary embolismPercutaneous peripheral arterial interventionsICD-9-CM codesHospital mortality differenceProlonged hospital stayHospital-level characteristicsPeripheral arterial interventionsNational Inpatient SampleHospital outcomesHospital stayIntervention patientsAbsence of heparinBaseline characteristicsHome dischargeLonger hospitalizationArterial interventionsHospitalized patientsInpatient SampleThrombocytopeniaClinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study
Yassin A, Subahi A, Adegbala O, Abubakar H, Dawdy J, Mishra T, Akintoye E, Shereef H, Ghandour M, Alhusain R, Shokr M, Oviedo C, Afonso L. Clinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study. Cardiovascular Revascularization Medicine 2019, 21: 522-526. PMID: 31439442, DOI: 10.1016/j.carrev.2019.07.022.Peer-Reviewed Original ResearchConceptsCost of hospitalizationAtrial fibrillationHospital mortalityHospital complicationsVentricular arrhythmiasNational Inpatient Sample databasePropensity score-matched analysisMajor cardiac complicationsTakotsubo syndrome patientsIn-Hospital MortalityNon-routine dischargeAtrial fibrillation groupAtrial fibrillation patientsShort-term outcomesNational Inpatient SampleLength of stayPotential confounding factorsCardiac complicationsHospital stayFibrillation groupFibrillation patientsSecondary outcomesTakotsubo syndromePrimary outcomeCardiac arrestIn-Hospital Outcomes of ST-Segment Elevation Myocardial Infarction Complicated With Cardiogenic Shock at Safety-Net Hospitals in the United States (from the Nationwide Inpatient Sample)
Ando T, Akintoye E, Adegbala O, Ashraf S, Shokr M, Takagi H, Grines C, Afonso L, Briasoulis A. In-Hospital Outcomes of ST-Segment Elevation Myocardial Infarction Complicated With Cardiogenic Shock at Safety-Net Hospitals in the United States (from the Nationwide Inpatient Sample). The American Journal Of Cardiology 2019, 124: 485-490. PMID: 31213279, DOI: 10.1016/j.amjcard.2019.05.037.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overArrhythmias, CardiacAssisted CirculationCoronary Artery BypassDatabases, FactualEthnicityFemaleHeart-Assist DevicesHospital MortalityHumansMaleMiddle AgedPercutaneous Coronary InterventionRenal DialysisSafety-net ProvidersShock, CardiogenicST Elevation Myocardial InfarctionStrokeThrombolytic TherapyUnited StatesConceptsSafety-net hospitalPercutaneous coronary interventionSTEMI-CSCardiogenic shockHospital mortalityCoronary interventionST-Segment Elevation Myocardial Infarction ComplicatedST-segment elevation myocardial infarctionAdministration of thrombolysisMyocardial Infarction ComplicatedCoronary artery bypassElevation myocardial infarctionMechanical circulatory supportNationwide Inpatient SampleNew dialysisArtery bypassHospital outcomesClinical outcomesCirculatory supportInpatient stayMedian lengthPoor outcomeFatal arrhythmiasInpatient SampleMyocardial infarctionIncidence and predictors of readmissions to non-index hospitals after transcatheter aortic valve replacement and the impact on in-hospital outcomes: From the nationwide readmission database
Ando T, Adegbala O, Villablanca P, Akintoye E, Ashraf S, Shokr M, Siddiqui F, Takagi H, Grines C, Afonso L, Briasoulis A. Incidence and predictors of readmissions to non-index hospitals after transcatheter aortic valve replacement and the impact on in-hospital outcomes: From the nationwide readmission database. International Journal Of Cardiology 2019, 292: 50-55. PMID: 31053244, DOI: 10.1016/j.ijcard.2019.04.056.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementNon-index hospitalsNon-index hospital readmissionsNon-index readmissionsAortic valve replacementNationwide Readmissions DatabaseHospital mortalityIndex hospitalHospital outcomesValve replacementHospital readmissionEndovascular transcatheter aortic valve replacementMetropolitan non-teaching hospitalsMultivariable logistic regression analysisAcute kidney injuryPredictors of readmissionAcute myocardial infarctionLength of stayLogistic regression analysisNon-teaching hospitalsElective readmissionsTAVR recipientsKidney injuryPacemaker placementHealthcare utilizationTrends in the Incidence of In-Hospital Mortality, Cardiogenic Shock, and Utilization of Mechanical Circulatory Support Devices in Myocarditis (Analysis of National Inpatient Sample Data, 2005–2014)
Pahuja M, Adegbala O, Mishra T, Akintoye E, Chehab O, Mony S, Singh M, Ando T, Abubaker H, Yassin A, Subahi A, Shokr M, Ranka S, Briasoulis A, Kapur N, Burkhoff D, Afonso L. Trends in the Incidence of In-Hospital Mortality, Cardiogenic Shock, and Utilization of Mechanical Circulatory Support Devices in Myocarditis (Analysis of National Inpatient Sample Data, 2005–2014). Journal Of Cardiac Failure 2019, 25: 457-467. PMID: 31035007, DOI: 10.1016/j.cardfail.2019.04.012.Peer-Reviewed Original ResearchConceptsIncidence of CSCardiogenic shockMechanical circulatory supportHospital mortalityMCS devicesPercutaneous ventricular assist deviceNational Inpatient Sample databaseMechanical circulatory support devicesIncidence of myocarditisPercutaneous cardiopulmonary supportCases of myocarditisIn-Hospital MortalityExtracorporeal membrane oxygenationCirculatory support devicesVentricular assist deviceTandem HeartHemodynamic instabilityMultiple comorbiditiesCardiopulmonary supportEndomyocardial biopsyMembrane oxygenationTotal admissionsCirculatory supportPatient mortalityPoor prognosisCharacteristics and Outcomes of Patients With Cardiogenic Shock Utilizing Hemodialysis for Acute Kidney Injury
Adegbala O, Inampudi C, Adejumo A, Otuonye G, Akintoye E, Elsayed R, Williams K, Alvarez P, Afonso L, Briasoulis A. Characteristics and Outcomes of Patients With Cardiogenic Shock Utilizing Hemodialysis for Acute Kidney Injury. The American Journal Of Cardiology 2019, 123: 1816-1821. PMID: 30967283, DOI: 10.1016/j.amjcard.2019.02.038.Peer-Reviewed Original ResearchConceptsLength of stayAcute kidney injuryCardiogenic shockOutcomes of patientsHospital mortalityKidney injuryTemporary mechanical supportCause of CSPropensity score-matched groupsST-elevation myocardial infarctionMechanical circulatory support devicesHigher comorbidity burdenRenal replacement therapyElevation myocardial infarctionHospital-level characteristicsRenal venous pressureNational Inpatient SampleCirculatory support devicesComorbidity burdenHospital morbidityHospital outcomesRenal functionBiventricular functionRenal perfusionVenous pressureTrends in In-Hospital Mortality, Length of Stay, Nonroutine Discharge, and Cost Among End-Stage Renal Disease Patients on Dialysis Hospitalized With Heart Failure (2001–2014)
Inampudi C, Akintoye E, Bengaluru Jayanna M, Asleh R, Briasouli A, Alvarez P, Briasoulis A. Trends in In-Hospital Mortality, Length of Stay, Nonroutine Discharge, and Cost Among End-Stage Renal Disease Patients on Dialysis Hospitalized With Heart Failure (2001–2014). Journal Of Cardiac Failure 2019, 25: 524-533. PMID: 30844441, DOI: 10.1016/j.cardfail.2019.02.020.Peer-Reviewed Original ResearchConceptsLength of stayEnd-stage renal disease patientsHF admissionsRenal disease patientsHospital mortalityNonroutine dischargeHeart failureESRD patientsDisease patientsStudy periodAnnual national ratesHF admission ratesPrevalence of comorbiditiesIn-Hospital MortalityNational Inpatient SampleCost of hospitalizationAnnual percentage changeYears of ageHF hospitalizationSecondary admissionsAdmission diagnosisComorbidity prevalencePeritoneal dialysisSubgroup analysisInpatient Sample
2018
Incidence, Trends, and Predictors of Palliative Care Consultation After Aortic Valve Replacement in the United States
Ando T, Adegbala O, Uemura T, Akintoye E, Ashraf S, Briasoulis A, Takagi H, Afonso L. Incidence, Trends, and Predictors of Palliative Care Consultation After Aortic Valve Replacement in the United States. Journal Of Palliative Care 2018, 34: 111-117. PMID: 30587081, DOI: 10.1177/0825859718819433.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementPC referral rateAdjusted odds ratioPC consultPC referralValve replacementIndex hospitalizationPC consultationReferral ratesTransapical transcatheter aortic valve replacementAortic valve replacement patientsNationwide Inpatient Sample databaseValve replacement patientsPalliative care consultPalliative care consultationMultivariable regression analysisCare consultTAVR cohortAcceptable morbidityInpatient mortalityReplacement patientsElectrolyte derangementsNIS database