2023
Prognostic Utility of Left Atrial Strain to Predict Thrombotic Events and Mortality in Amyloid Cardiomyopathy
Akintoye E, Majid M, Klein A, Hanna M. Prognostic Utility of Left Atrial Strain to Predict Thrombotic Events and Mortality in Amyloid Cardiomyopathy. JACC Cardiovascular Imaging 2023, 16: 1371-1383. PMID: 37940322, DOI: 10.1016/j.jcmg.2023.01.015.Peer-Reviewed Original ResearchConceptsThrombotic eventsAmyloid cardiomyopathyAtrial fibrillationLA contractileLA strainLA contractile strainModest discriminatory abilityPrognostic staging systemRisk stratification toolLeft Atrial StrainHigh thrombotic riskAtrial strainPrognostic utilityStratification toolPrognostic valueC-statisticRespective HRsStaging systemThrombotic riskACM patientsSD decreaseAF casesPredictive valuePatientsDiscriminatory abilityLeft Ventricular Global Longitudinal Strain Before TAVR Time to Jump the Ejection Fraction Ship? ∗
Desai M, Akintoye E. Left Ventricular Global Longitudinal Strain Before TAVR Time to Jump the Ejection Fraction Ship? ∗. JACC Cardiovascular Imaging 2023, 16: 342-344. PMID: 36889850, DOI: 10.1016/j.jcmg.2023.01.011.Peer-Reviewed Original ResearchAtrial Functional Tricuspid Regurgitation Do We Blame the AF, Right Atrium, or Both? ∗
Wang T, Akintoye E. Atrial Functional Tricuspid Regurgitation Do We Blame the AF, Right Atrium, or Both? ∗. JACC Cardiovascular Imaging 2023, 16: 588-590. PMID: 36752438, DOI: 10.1016/j.jcmg.2022.12.007.Peer-Reviewed Original ResearchAtrial FibrillationHeart AtriaHumansPredictive Value of TestsTricuspid ValveTricuspid Valve Insufficiency
2022
Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation
Akintoye E, Wang T, Nakhla M, Ali A, Fava A, Akyuz K, Popovic Z, Pettersson G, Gillinov A, Xu B, Griffin B, Desai M. Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation. JACC Cardiovascular Imaging 2022, 16: 13-24. PMID: 36274042, DOI: 10.1016/j.jcmg.2022.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedEchocardiographyFemaleHumansMalePredictive Value of TestsRetrospective StudiesSeverity of Illness IndexTricuspid ValveTricuspid Valve InsufficiencyConceptsTricuspid regurgitationMedian survival timeRisk factorsAsymptomatic patientsEchocardiographic parametersSurvival timeEarly interventionOptimal timingRight heart parametersSymptomatic tricuspid regurgitationSignificant tricuspid regurgitationFree wall strainHigh operative mortalitySex-matched cohortQuantitative echocardiographic assessmentKey prognostic markersCause mortalityOperative mortalityTR patientsEchocardiographic assessmentLate presentationPoor outcomePrognostic utilityPrognostic valuePrognostic marker
2021
Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts
Akintoye E, Afonso L, Jayanna M, Bao W, Briasoulis A, Robinson J. Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts. Journal Of The American Heart Association 2021, 10: e019589. PMID: 34092110, PMCID: PMC8477885, DOI: 10.1161/jaha.120.019589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationBiomarkersCardiovascular DiseasesCholesterolClinical Decision-MakingCoronary Artery DiseaseDecision Support TechniquesDyslipidemiasFemaleHeart Disease Risk FactorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedPractice Guidelines as TopicPredictive Value of TestsPrimary PreventionPrognosisRisk AssessmentTime FactorsUnited StatesVascular CalcificationConceptsPooled Cohort EquationsCoronary artery calcium scoreCholesterol treatment guidelinesArtery calcium scoreAtherosclerotic cardiovascular diseaseCohort EquationsRisk enhancersCalcium scoreTreatment guidelinesCardiovascular diseaseAmerican Heart Association/American CollegeAtherosclerotic cardiovascular disease eventsBackground Limited dataIntermediate-risk participantsIntermediate-risk patientsCardiovascular disease eventsLarge prospective cohortIncremental valueNet reclassification indexStatin therapyCAC testingProspective cohortPrognostic utilityC-statisticReclassification index
2018
Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis
Adegbala O, Olagoke O, Akintoye E, Adejumo A, Oluwole A, Jara C, Williams K, Briasoulis A, Afonso L. Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis. The American Journal Of Cardiology 2018, 123: 139-144. PMID: 30539745, DOI: 10.1016/j.amjcard.2018.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultArrhythmias, CardiacFemaleHospital CostsHospital MortalityHumansLength of StayMaleMiddle AgedMyocarditisPredictive Value of TestsUnited StatesConceptsImpact of arrhythmiasCardiac arrhythmiasAcute myocarditisNonroutine hospital dischargePredictors of arrhythmiasPropensity-matched analysisMechanical circulatory supportSudden cardiac deathOccurrence of arrhythmiasCost of hospitalizationLength of staySignificant proportionHospital mortalityCardiogenic shockHospital outcomesHospital dischargeMyocarditis casesCardiac deathIndependent predictorsPacemaker implantationAtrial fibrillationCirculatory supportCommon arrhythmiaVentricular tachycardiaWorse outcomesIncidence, Predictors, and In-Hospital Outcomes of Transcatheter Aortic Valve Implantation After Nonelective Admission in Comparison With Elective Admission: From the Nationwide Inpatient Sample Database
Ando T, Adegbala O, Villablanca P, Akintoye E, Ashraf S, Shokr M, Briasoulis A, Takagi H, Grines C, Afonso L, Schreiber T. Incidence, Predictors, and In-Hospital Outcomes of Transcatheter Aortic Valve Implantation After Nonelective Admission in Comparison With Elective Admission: From the Nationwide Inpatient Sample Database. The American Journal Of Cardiology 2018, 123: 100-107. PMID: 30360892, DOI: 10.1016/j.amjcard.2018.09.023.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationNationwide Inpatient Sample databaseNonelective admissionsPropensity-matched cohortAortic valve implantationHospital mortalityValve implantationElective admissionsOutcomes of TAVITransarterial transcatheter aortic valve implantationSample databaseHigher adverse outcomesPulmonary circulation disordersAcute kidney injuryHealth resource utilizationIn-Hospital OutcomesChronic kidney diseaseIndependent risk factorCongestive heart failureHigh-risk cohortAcute myocardial infarctionCardiogenic shockHospital lengthKidney injuryRespiratory failureRacial/ethnic differences in the prognostic utility of left ventricular mass index for incident cardiovascular disease
Akintoye E, Mahmoud K, Shokr M, Sandio A, Mallikethi‐Reddy S, Sheikh M, Adegbala O, Egbe A, Briasoulis A, Afonso L. Racial/ethnic differences in the prognostic utility of left ventricular mass index for incident cardiovascular disease. Clinical Cardiology 2018, 41: 502-509. PMID: 29663526, PMCID: PMC6490106, DOI: 10.1002/clc.22914.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsianBlack or African AmericanCardiovascular DiseasesComorbidityDatabases, FactualDisease ProgressionFemaleHispanic or LatinoHumansHypertrophy, Left VentricularIncidenceMagnetic Resonance Imaging, CineMaleMiddle AgedPredictive Value of TestsPrognosisProportional Hazards ModelsRacial GroupsRisk FactorsTime FactorsUnited StatesVentricular Function, LeftVentricular RemodelingWhite PeopleConceptsLeft ventricular mass indexLeft ventricular hypertrophyNon-Hispanic whitesVentricular mass indexCVD eventsIncident CVDMass indexPrognostic utilityEthnic differencesFuture cardiovascular disease eventsOptimal cutpointCardiovascular disease eventsFuture CVD eventsIncident cardiovascular diseaseRisk stratification strategiesIncident cardiovascular outcomesMulti-Ethnic StudyRace/ethnicityCardiovascular outcomesLVMI valuesVentricular hypertrophyCardiovascular diseaseDisease eventsCox modelStratification strategies
2017
Early Prosthetic Valve Dysfunction Due to Bioprosthetic Valve Thrombosis The Role of Echocardiography
Egbe A, Pislaru S, Ali M, Khan A, Boler A, Schaff H, Akintoye E, Connolly H, Nkomo V, Pellikka P. Early Prosthetic Valve Dysfunction Due to Bioprosthetic Valve Thrombosis The Role of Echocardiography. JACC Cardiovascular Imaging 2017, 11: 951-958. PMID: 29055629, DOI: 10.1016/j.jcmg.2017.06.022.Peer-Reviewed Original ResearchConceptsProsthetic valve dysfunctionBioprosthetic valve thrombosisTransthoracic echocardiographyPVD diagnosisValve thrombosisValve implantationRetrospective case-control studyAcute disease processPatients ages 61Role of echocardiographyRoutine transthoracic echocardiographyCase-control studyMen 61Symptomatic deteriorationMost patientsValve dysfunctionAppropriate therapyInitial diagnosisSF patientsBioprosthetic valvesTimely diagnosisPatient's conditionBaseline gradientAge 61Disease processRole of diastolic function indices in the risk stratification of patients with mixed aortic valve disease
Egbe A, Khan A, Boler A, Said S, Geske J, Miranda W, Akintoye E, Connolly H, Warnes C, Oh J. Role of diastolic function indices in the risk stratification of patients with mixed aortic valve disease. European Heart Journal - Cardiovascular Imaging 2017, 19: 668-674. PMID: 28655164, DOI: 10.1093/ehjci/jex148.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnalysis of VarianceAortic Valve InsufficiencyAortic Valve StenosisAsymptomatic DiseasesCohort StudiesConfidence IntervalsDiastoleEchocardiographyFemaleHumansMaleMiddle AgedMonitoring, PhysiologicPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentSex FactorsStroke VolumeSurvival RateUnited StatesConceptsAortic valve replacementCardiovascular adverse eventsRelative wall thicknessMixed aortic valve diseaseDiastolic function indicesAortic valve diseaseCardiac deathRisk stratificationValve diseaseFunction IndexHigh-risk patient subsetsPost-operative risk stratificationSevere left ventricular dysfunctionAtrial volume indexHeart failure hospitalizationTricuspid regurgitation velocityEarly diastolic velocityLeft ventricular dysfunctionMultivariable risk factorsAsymptomatic patientsCardiovascular morbidityFailure hospitalizationPrimary endpointSecondary endpointsVentricular dysfunctionUsefulness of the Mitral Regurgitation Severity Index to Assess the Severity of Chronic Mitral Regurgitation
Afonso L, Shokr M, Akintoye E, Briasoulis A, Alesh I, Alani A, Mahajan N, Veeranna V, Mostafa A, Zmily H, Telila T, Zalawadiya S. Usefulness of the Mitral Regurgitation Severity Index to Assess the Severity of Chronic Mitral Regurgitation. The American Journal Of Cardiology 2017, 120: 304-308. PMID: 28550931, DOI: 10.1016/j.amjcard.2017.04.027.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityChronic DiseaseEchocardiography, Doppler, ColorEchocardiography, TransesophagealFemaleFollow-Up StudiesHumansMaleMiddle AgedMitral ValveMitral Valve InsufficiencyPredictive Value of TestsReproducibility of ResultsRetrospective StudiesROC CurveSeverity of Illness IndexConceptsSevere mitral regurgitationMitral regurgitationTime-velocity integralVelocity integralNonsevere mitral regurgitationChronic mitral regurgitationInter-rater reproducibilityOptimal diagnostic accuracyDerivation cohortMitral inflowValidation cohortGood inter-rater reproducibilityHigh interobserver variabilityMR severityInter-rater agreementLevel IIMean differenceDiagnostic accuracyInterobserver variabilitySeverity IndexCut pointsRegurgitationPatientsCohortSeverityCardiopulmonary exercise test in adults with prior Fontan operation: The prognostic value of serial testing
Egbe A, Driscoll D, Khan A, Said S, Akintoye E, Berganza F, Connolly H. Cardiopulmonary exercise test in adults with prior Fontan operation: The prognostic value of serial testing. International Journal Of Cardiology 2017, 235: 6-10. PMID: 28284501, DOI: 10.1016/j.ijcard.2017.02.140.Peer-Reviewed Original ResearchConceptsSerial cardiopulmonary exercise testsCardiovascular adverse eventsCardiopulmonary exercise testPercentage points/yearPoints/yearFontan operationPeak VOExercise testBaseline cardiopulmonary exercise testBaseline peak oxygen consumptionAdult Fontan patientsAdult Fontan populationPrior Fontan operationPeak oxygen consumptionPeak heart rateFontan populationFontan palliationFontan patientsPeak exerciseAdverse eventsCardiac surgeryRetrospective reviewPrognostic valueInclusion criteriaSerial testing
2015
Association between fine particulate matter exposure and subclinical atherosclerosis: A meta-analysis
Akintoye E, Shi L, Obaitan I, Olusunmade M, Wang Y, Newman J, Dodson J. Association between fine particulate matter exposure and subclinical atherosclerosis: A meta-analysis. European Journal Of Preventive Cardiology 2015, 23: 602-612. PMID: 26025448, PMCID: PMC5133694, DOI: 10.1177/2047487315588758.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessAnkle-brachial indexIntima-media thicknessSubclinical atherosclerosisArterial calcificationMedia thicknessFine particulate matter exposureAvailable observational studiesParticulate matter exposureRandom-effects modelNumber of studiesObservational studyInclusion criteriaEpidemiological studiesMatter exposureStudy heterogeneityPM2.5 exposureNoninvasive measureAtherosclerosisSimilar associationComprehensive searchConfidence intervalsStatistical significanceCalcificationAssociation