2024
Role of Cardiac MRI in Pericardial Diseases
Anthony C, Akintoye E, Wang T, Klein A. Role of Cardiac MRI in Pericardial Diseases. Current Cardiovascular Imaging Reports 2024, 17: 43-51. DOI: 10.1007/s12410-024-09591-x.Peer-Reviewed Original ResearchDiagnosis of pericardial diseaseResponse to therapyPericardial diseaseCardiac MRIDiagnosis of pericarditisInitiation of treatmentCardiac MRI techniquesRecurrent pericarditisAcute pericarditisMedical therapyAdjunctive roleTherapyPericarditisDiagnosisDiseaseImaging toolCardiacPatientsMRISummaryCMRPrognosis
2023
Prognostic Utility of Left Atrial Strain to Predict Thrombotic Events and Mortality in Amyloid Cardiomyopathy
Akintoye E, Majid M, Klein A, Hanna M. Prognostic Utility of Left Atrial Strain to Predict Thrombotic Events and Mortality in Amyloid Cardiomyopathy. JACC Cardiovascular Imaging 2023, 16: 1371-1383. PMID: 37940322, DOI: 10.1016/j.jcmg.2023.01.015.Peer-Reviewed Original ResearchConceptsThrombotic eventsAmyloid cardiomyopathyAtrial fibrillationLA contractileLA strainLA contractile strainModest discriminatory abilityPrognostic staging systemRisk stratification toolLeft Atrial StrainHigh thrombotic riskAtrial strainPrognostic utilityStratification toolPrognostic valueC-statisticRespective HRsStaging systemThrombotic riskACM patientsSD decreaseAF casesPredictive valuePatientsDiscriminatory abilityImpact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Akintoye E, Saijo Y, Braghieri L, Badwan O, Patel H, Dabbagh M, El Dahdah J, Jellis C, Desai M, Rodriguez L, Grimm R, Griffin B, Popović Z. Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. Journal Of The American College Of Cardiology 2023, 81: 1474-1487. PMID: 37045517, DOI: 10.1016/j.jacc.2023.02.037.Peer-Reviewed Original ResearchConceptsSmaller LV volumesAdverse eventsAortic regurgitationBody surface areaOlder patientsYounger patientsLV volumesImpact of ageLV remodelingSerial evaluationLV end-systolic volumeLV end-diastolic volumeSevere aortic regurgitationChronic aortic regurgitationLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volumeLower LV volumesAdult patientsConsecutive patientsMain endpointVentricular dimensionsVentricular remodelingCurrent guidelinesPatientsTEMPORALITY OF ISCHEMIC STROKE AND NEW-ONSET ATRIAL FIBRILLATION AND THE UTILITY OF LEFT ATRIAL STRAIN IN PATIENTS WITH CARDIAC AMYLOIDOSIS
Akintoye E, Majid M, Hanna M, Klein A. TEMPORALITY OF ISCHEMIC STROKE AND NEW-ONSET ATRIAL FIBRILLATION AND THE UTILITY OF LEFT ATRIAL STRAIN IN PATIENTS WITH CARDIAC AMYLOIDOSIS. Journal Of The American College Of Cardiology 2023, 81: 340. DOI: 10.1016/s0735-1097(23)00784-2.Peer-Reviewed Original ResearchINTRA- AND INTER-OBSERVER VARIABILITY IN LEFT ATRIAL STRAIN ANALYSIS IN PATIENTS WITH AMYLOID CARDIOMYOPATHY
Majid M, Akintoye E, Yaker Z, Karmali R, Syed A, Agrawal A, Kumar A, Hanna M, Moudgil R, Klein A. INTRA- AND INTER-OBSERVER VARIABILITY IN LEFT ATRIAL STRAIN ANALYSIS IN PATIENTS WITH AMYLOID CARDIOMYOPATHY. Journal Of The American College Of Cardiology 2023, 81: 610. DOI: 10.1016/s0735-1097(23)01054-9.Peer-Reviewed Original Research
2022
Clinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation
Layoun H, Mentias A, Akintoye E, Matta M, Kanaan C, Daou R, Ramchand J, Burns D, Gillinov A, Bhattacharya S, Puri R, Collier P, Griffin B, Kapadia S, Harb S. Clinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation. Open Heart 2022, 9: e001996. PMID: 35383126, PMCID: PMC8984044, DOI: 10.1136/openhrt-2022-001996.Peer-Reviewed Original ResearchConceptsSecondary mitral regurgitationAtrial dilationMitral regurgitationPrognostic implicationsSevere left atrial dilationSevere secondary mitral regurgitationLA reservoir strainLeft atrial dilationLeft ventricle dysfunctionPoor prognostic indicatorMV interventionVentricle dysfunctionMore diabetesAdult patientsTransthoracic echocardiographyEjection fractionIndependent predictorsAtrial fibrillationReservoir strainWorse prognosisPrognostic indicatorMR severityBetter outcomesFunctional alterationsPatientsWait List And Transplant Outcomes Of Diabetic Patients With Listed For Heart Transplantation: A Propensity-matched Analysis
Akintoye E, Alvarez P, Salih M, Briasoulis A. Wait List And Transplant Outcomes Of Diabetic Patients With Listed For Heart Transplantation: A Propensity-matched Analysis. Journal Of Cardiac Failure 2022, 28: s64. DOI: 10.1016/j.cardfail.2022.03.163.Peer-Reviewed Original ResearchDiabetic patientsWaitlist mortalityHeart transplantPost-transplant graft survivalEnd-stage heart failurePropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureHeart failureUnited NetworkRisk factorsOrgan SharingPatientsStudy periodTransplantMortalityFailureCohortWaitlistTrends In Waitlist And Post-transplant Outcomes After Heart Transplantation In The United States: Analysis OfUNOS Database 1991-2019
Akintoye E, Alvarez P, Shin D, Panos A, Briasoulis A. Trends In Waitlist And Post-transplant Outcomes After Heart Transplantation In The United States: Analysis OfUNOS Database 1991-2019. Journal Of Cardiac Failure 2022, 28: s61-s62. DOI: 10.1016/j.cardfail.2022.03.157.Peer-Reviewed Original ResearchPost-transplant outcomesHeart transplantationWaitlist mortalityPatient characteristicsAdult heart transplant recipientsHeart transplant recipientsHigh-risk comorbiditiesShort-term survivalHospital strokeHospital lengthTransplant recipientsRenal failureWaitlist deathsPatient selectionUnited NetworkPatient outcomesTransplant volumeSurgical techniqueEra 1Organ SharingEra 4PatientsNational databaseStudy periodTime pointsOutcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis
Akintoye E, Alvarez P, Salih M, Sellke F, Briasoulis A. Outcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis. Clinical Transplantation 2022, 36: e14590. PMID: 35018661, DOI: 10.1111/ctr.14590.Peer-Reviewed Original ResearchConceptsDiabetic patientsWaitlist mortalityHeart transplantPost-transplant graft survivalEnd-stage heart failurePropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureHeart failureUnited NetworkRisk factorsOrgan SharingPatientsStudy periodTransplantMortalityFailureCohortWaitlist
2021
Changing Demographics, Temporal Trends in Waitlist, and Posttransplant Outcomes After Heart Transplantation in the United States: Analysis of the UNOS Database 1991–2019
Akintoye E, Alvarez P, Shin D, Egbe A, Panos A, Sellke F, Briasoulis A. Changing Demographics, Temporal Trends in Waitlist, and Posttransplant Outcomes After Heart Transplantation in the United States: Analysis of the UNOS Database 1991–2019. Circulation Heart Failure 2021, 14: e008764. PMID: 34689572, DOI: 10.1161/circheartfailure.121.008764.Peer-Reviewed Original ResearchConceptsHeart transplantationPosttransplant outcomesPatient characteristicsHigh-risk comorbiditiesCharacteristics of patientsShort-term survivalRisk comorbiditiesHospital strokeWaitlist mortalityRenal failureUnited NetworkTransplant volumeEra 1Organ SharingPatientsTransplantationWaitlistEra 4Study periodTime pointsSignificant decreaseTemporal trendsOutcomesSignificant changesUnited StatesChanging demographics, temporal trend in waitlist and post-transplant outcomes after heart transplantation in the United States: analysis of unos database 1991–2019
Akintoye E, Alvarez P, Shin D, Egbe A, Panos A, Briasoulis A. Changing demographics, temporal trend in waitlist and post-transplant outcomes after heart transplantation in the United States: analysis of unos database 1991–2019. European Heart Journal 2021, 42: ehab724.0953. DOI: 10.1093/eurheartj/ehab724.0953.Peer-Reviewed Original ResearchPost-transplant outcomesHeart transplantationWaitlist mortalityPatient characteristicsAdult heart transplant recipientsHeart transplant recipientsHigh-risk comorbiditiesCharacteristics of patientsShort-term survivalHospital strokeHospital lengthTransplant recipientsRenal failureWaitlist deathsPatient selectionUnited NetworkPatient outcomesTransplant volumeSurgical techniqueEra 1Organ SharingPatientsEra 4National databaseStudy periodOutcomes of diabetic patients with end-stage heart failure listed for heart transplantation: a propensity-matched analysis
Akintoye E, Alvarez P, Briasoulis A. Outcomes of diabetic patients with end-stage heart failure listed for heart transplantation: a propensity-matched analysis. European Heart Journal 2021, 42: ehab724.0967. DOI: 10.1093/eurheartj/ehab724.0967.Peer-Reviewed Original ResearchHeart transplantWaitlist mortalityPost-transplant graft survivalEnd-stage heart failureOutcomes of patientsPropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureDiabetic patientsHeart failureDiabetic cohortPoor outcomeUnited NetworkRisk factorsOrgan SharingPatientsTransplantStudy periodCohortMortalityOutcomesRiskPrognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices
Ali A, Akintoye E, Duque E, Kshetri R, Shetty S, Sharma U, Johnson C, Panos A, Briasoulis A, Alvarez P. Prognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices. ASAIO Journal 2021, 68: 524-530. PMID: 34352812, DOI: 10.1097/mat.0000000000001524.Peer-Reviewed Original ResearchConceptsNT-pro BNP concentrationHF hospitalizationBNP concentrationsVentricular assist devicePrognostic implicationsN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideAssist deviceHeart failure hospitalizationNT-pro BNPFailure hospitalizationIndex hospitalizationAdverse eventsLVAD implantationConsecutive patientsAmbulatory patientsNatriuretic peptideRetrospective studyHospitalizationAmbulatory settingPatientsMonth baselineMonthsDeathUnit increase
2020
Intermediate and Late Outcomes With PCI vs CABG for Left Main Disease — Landmark Meta-Analysis of Randomized Trials
Akintoye E, Salih M, Olagoke O, Oseni A, Sistla P, Alqasrawi M, Panos A, Panaich S, Sellke F. Intermediate and Late Outcomes With PCI vs CABG for Left Main Disease — Landmark Meta-Analysis of Randomized Trials. Cardiovascular Revascularization Medicine 2020, 23: 114-118. PMID: 32921597, DOI: 10.1016/j.carrev.2020.08.040.Peer-Reviewed Original ResearchConceptsUnprotected left main diseaseLeft main diseaseEXCEL trialLate mortalityCause mortalityDirection of associationRandomized trialsLate outcomesCABGLate MIMain diseaseReasonable alternativePCITrialsSignificant differencesRCTsLower ratesHigh rateMortalityYearsLong termPatientsMixed resultsPRECOMBATStrokeCharacteristics and Outcomes of Patients Undergoing Combined Organ Transplantation (from the United Network for Organ Sharing)
Briasoulis A, Akintoye E, Kuno T, Alvarez P. Characteristics and Outcomes of Patients Undergoing Combined Organ Transplantation (from the United Network for Organ Sharing). The American Journal Of Cardiology 2020, 129: 42-45. PMID: 32540168, DOI: 10.1016/j.amjcard.2020.05.034.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCardiomyopathy, DilatedCardiomyopathy, RestrictiveFemaleGraft RejectionHeart Defects, CongenitalHeart FailureHeart TransplantationHeart-Lung TransplantationHispanic or LatinoHumansKidney DiseasesKidney TransplantationLiver DiseasesLiver TransplantationLung DiseasesMaleMiddle AgedMortalityProportional Hazards ModelsRegistriesReoperationSurvival RateWhite PeopleConceptsHeart-liver transplantPrimary heart transplantationLong-term survivalHeart transplantationOrgan transplantsStage D heart failureD heart failureOutcomes of patientsOrgan Sharing registryLong-term outcomesCongenital heart diseaseAdult patientsMedian survivalHeart failureTransplantation ratesUnited NetworkList timeHeart diseaseOperative characteristicsOrgan transplantationSurvival analysisPatientsTransplantInverse probabilityStudy periodTrends, Outcomes, and Readmissions Among Left Ventricular Assist Device Recipients with Acute Kidney Injury Requiring Hemodialysis.
Adegbala O, Olakanmi O, Akintoye E, Inampudi C, Pahuja M, Alvarez P, Briasoulis A. Trends, Outcomes, and Readmissions Among Left Ventricular Assist Device Recipients with Acute Kidney Injury Requiring Hemodialysis. ASAIO Journal 2020, 66: 507-512. PMID: 31192850, DOI: 10.1097/mat.0000000000001036.Peer-Reviewed Original ResearchConceptsAcute kidney injuryLength of stayHospital mortalityKidney injuryLVAD recipientsMaintenance hemodialysisLVAD implantationAcute Kidney Injury Requiring HemodialysisVentricular assist device implantationVentricular assist device recipientsNational Readmission DatabaseAssist device implantationReduced hospital costsHospital outcomesPostoperative bleedingHospital dischargeRenal functionDevice implantationDevice recipientsHemodialysis therapyHospital characteristicsHospital costsHemodialysisReadmissionPatientsTemporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation
Briasoulis A, Adegbala O, Akintoye E, Alvarez P. Temporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation. Clinical Transplantation 2020, 34: e13857. PMID: 32167606, DOI: 10.1111/ctr.13857.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceRight ventricular assist deviceVentricular assist deviceOutcomes of patientsTime of listingTime of transplantationHeart transplantationAssist deviceOrgan Sharing registryTerms of survivalStatus 1AInotropic therapyLVAD recipientsUnited NetworkWorse outcomesInotropesHigh riskWaiting listPatientsTransplantationLower ratesOutcomesTemporal trendsConfoundersRegistryTemporal Trends and Outcomes of Patients Undergoing Combined Organ Transplantation: Insights from the United Network for Organ Sharing (UNOS)
Briasoulis A, Akintoye E, Alvarez P. Temporal Trends and Outcomes of Patients Undergoing Combined Organ Transplantation: Insights from the United Network for Organ Sharing (UNOS). The Journal Of Heart And Lung Transplantation 2020, 39: s167-s168. DOI: 10.1016/j.healun.2020.01.1126.Peer-Reviewed Original ResearchHeart-liver transplantPrimary heart transplantationLong-term survivalHeart transplantationUnited NetworkOrgan transplantsStage D heart failureD heart failureMethods Adult patientsOutcomes of patientsOrgan Sharing registryLong-term outcomesCongenital heart diseaseAdult patientsMedian survivalHeart failureTransplantation ratesList timeHeart diseaseOperative characteristicsOrgan transplantationOrgan SharingSurvival analysisPatientsTransplantRural–Urban Disparities in Intracerebral Hemorrhage Mortality in the USA: Preliminary Findings from the National Inpatient Sample
Otite F, Akano E, Akintoye E, Khandelwal P, Malik A, Chaturvedi S, Rosand J. Rural–Urban Disparities in Intracerebral Hemorrhage Mortality in the USA: Preliminary Findings from the National Inpatient Sample. Neurocritical Care 2020, 32: 715-724. PMID: 32232726, PMCID: PMC7223184, DOI: 10.1007/s12028-020-00950-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAphasiaCerebral HemorrhageComorbidityCraniotomyDeglutition DisordersFemaleHealthcare DisparitiesHospital Bed CapacityHospital MortalityHospitals, RuralHospitals, UrbanHumansHydrocephalusMaleMiddle AgedRespiration, ArtificialRisk FactorsUnited StatesYoung AdultConceptsNational Inpatient SampleSex-adjusted mortalityUrban hospitalRural hospitalsICH patientsInpatient SampleJoinpoint regressionIntracerebral hemorrhage mortalityMultivariable-adjusted modelsOdds of mortalityIntracerebral hemorrhage patientsCases of ICHHospital deathHospital mortalityMultivariable adjustmentUrban patientsRural patientsStroke careHemorrhage patientsMedicare insuranceRural-urban disparitiesPatientsResultsFrom 2004HospitalMortality gapThe impact of insurance type on listing status and wait‐list mortality of patients with left ventricular assist devices as bridge to transplantation
Briasoulis A, Akintoye E, Inampudi C, Hammoud A, Alvarez P. The impact of insurance type on listing status and wait‐list mortality of patients with left ventricular assist devices as bridge to transplantation. ESC Heart Failure 2020, 7: 804-810. PMID: 32135039, PMCID: PMC7261523, DOI: 10.1002/ehf2.12655.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceInsurance typeVentricular assist deviceTime of listingWaiting listAssist deviceHeart transplantation candidatesOrgan Sharing registryWait-list mortalityRisk regression analysisDifferent insurance typesAdequate health insurance coverageHealth insurance coverageStatus 1APublic health insuranceCumulative incidenceTransplantation candidatesTransplantation ratesUnited NetworkPost-HTMA patientsType of insurancePatientsMortalityCumulative mortality