MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos
Kasper DM, Moro A, Ristori E, Narayanan A, Hill-Teran G, Fleming E, Moreno-Mateos M, Vejnar CE, Zhang J, Lee D, Gu M, Gerstein M, Giraldez A, Nicoli S. MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos. Developmental Cell 2017, 40: 552-565.e5. PMID: 28350988, PMCID: PMC5404386, DOI: 10.1016/j.devcel.2017.02.021.Peer-Reviewed Original ResearchConceptsDevelopment of vertebratesEmbryonic blood vesselsVertebrate miRNAsMutant embryosVertebrate embryosHigher organismsMiRNAs functionVascular traitsTrait varianceUniform traitTissue developmentEnvironmental perturbationsSignaling pathwaysPhenotypic variabilityEmbryosPhenotypic heterogeneityOrganismsTraitsProper functioningVascular systemVertebratesMutagenesisMiRNAsMicroRNAsPhenotype