ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL-8/Notch signaling cascade
Ciccone V, Terzuoli E, Ristori E, Filippelli A, Ziche M, Morbidelli L, Donnini S. ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL-8/Notch signaling cascade. International Journal Of Molecular Medicine 2022, 50: 99. PMID: 35656893, PMCID: PMC9186295, DOI: 10.3892/ijmm.2022.5155.Peer-Reviewed Original ResearchConceptsIL-8Endothelial cellsMelanoma cellsTumor cellsALDH1A1 expressionAngiogenic factorsAngiogenic featuresTumor microenvironmentCancer cellsPoor clinical outcomeHigher microvessel densityNumber of cancersPro-angiogenic phenotypeOverexpression of ALDH1A1ALDH1A1 overexpressionClinical outcomesCo-culture systemMicrovessel densityImmunodeficient miceNF-kBProangiogenic factorsMelanoma cancer cellsTumor angiogenesisMelanoma controlStromal cellsChapter 2 Antiangiogenic drugs: Chemosensitizers for combination cancer therapy
Donnini S, Filippelli A, Ciccone V, Spini A, Ristori E, Ziche M, Morbidelli L. Chapter 2 Antiangiogenic drugs: Chemosensitizers for combination cancer therapy. 2022, 29-66. DOI: 10.1016/b978-0-323-90190-1.00008-1.Peer-Reviewed Original ResearchImmune-competent T cellsAntiangiogenic drugsVascular normalizationT cellsTumor vasculatureTumor microenvironmentTumor areaImmune checkpoint inhibitorsAnticancer drugsCheckpoint inhibitorsImmune therapyAdvanced tumorsCombination therapyPromising chemosensitizerAntiangiogenic therapyTarget therapyTumor disseminationAnticancer chemoClinical developmentEffective deliverySolid tumorsTherapyTumor progressionTumor resistanceTumor angiogenesis