2024
Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes
Olfson E, Farhat L, Liu W, Vitulano L, Zai G, Lima M, Parent J, Polanczyk G, Cappi C, Kennedy J, Fernandez T. Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. Nature Communications 2024, 15: 5870. PMID: 38997333, PMCID: PMC11245598, DOI: 10.1038/s41467-024-50247-7.Peer-Reviewed Original ResearchConceptsDNA sequencesRisk genesHigh-confidence risk genesWhole-exome DNA sequencingSequencing of familiesIdentified de novoLysine demethylase 5BDNA variantsTrio cohortBiological pathwaysGenesSequencing cohortGenetic factorsChildhood neurodevelopmental disordersAttention-deficit/hyperactivity disorderSequenceVariantsADHD riskNeurodevelopmental disordersKDM5BDNAMutationsFamilyLysineDiscoveryThe genetics of trichotillomania and excoriation disorder: A systematic review
Reid M, Lin A, Farhat L, Fernandez T, Olfson E. The genetics of trichotillomania and excoriation disorder: A systematic review. Comprehensive Psychiatry 2024, 133: 152506. PMID: 38833896, DOI: 10.1016/j.comppsych.2024.152506.Peer-Reviewed Original ResearchSystematic reviewGenome-wide researchGenome-wide associationDNA sequencing studiesDiscovery of risk genesWeb of ScienceGenetic factorsObsessive-compulsive disorderGenetic epidemiologyGenetic risk factorsSequencing studiesRisk genesGeneral populationMolecular geneticsExcoriation disorderRisk factorsGeneticsFirst-line medicationPsychiatric disordersObsessive-compulsive related disordersObsessive-compulsive disorder spectrumBody-focused repetitive behaviorsDevelopment of trichotillomaniaPsycINFOGenome
2023
Primary complex motor stereotypies are associated with de novo damaging DNA coding mutations that identify KDM5B as a risk gene
Fernandez T, Williams Z, Kline T, Rajendran S, Augustine F, Wright N, Sullivan C, Olfson E, Abdallah S, Liu W, Hoffman E, Gupta A, Singer H. Primary complex motor stereotypies are associated with de novo damaging DNA coding mutations that identify KDM5B as a risk gene. PLOS ONE 2023, 18: e0291978. PMID: 37788244, PMCID: PMC10547198, DOI: 10.1371/journal.pone.0291978.Peer-Reviewed Original ResearchConceptsRisk genesDe novo damaging variantsGene expression patternsWhole-exome DNA sequencingMid-fetal developmentAdditional risk genesHigh-confidence risk genesParent-child triosGene OntologyCell signalingExpression patternsCalcium ion transportFunctional convergenceCell cycleDamaging variantsGenesDNA sequencingDe novoASD probandsGenetic etiologyBiological mechanismsSequencingDNANetwork analysisIon transport25.4 Pharmacologic Interventions for Trichotillomania and Excoriation Disorder
Bloch M, Farhat L, Olfson E. 25.4 Pharmacologic Interventions for Trichotillomania and Excoriation Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: s363. DOI: 10.1016/j.jaac.2023.07.760.Peer-Reviewed Original ResearchPediatric Body-Focused Repetitive Behaviors: A Research Update on Clinical Characteristics and Treatment Strategies
Olfson E, Piacentini J. Pediatric Body-Focused Repetitive Behaviors: A Research Update on Clinical Characteristics and Treatment Strategies. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: s362. DOI: 10.1016/j.jaac.2023.07.756.Peer-Reviewed Original Research25.1 Prevalence and Clinical Characteristics of Trichotillomania and Excoriation Disorder
Farhat L, Bloch M, Olfson E. 25.1 Prevalence and Clinical Characteristics of Trichotillomania and Excoriation Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: s362. DOI: 10.1016/j.jaac.2023.07.757.Peer-Reviewed Original ResearchPrevalence and gender distribution of excoriation (skin-picking) disorder: A systematic review and meta-analysis
Farhat L, Reid M, Bloch M, Olfson E. Prevalence and gender distribution of excoriation (skin-picking) disorder: A systematic review and meta-analysis. Journal Of Psychiatric Research 2023, 161: 412-418. PMID: 37023597, PMCID: PMC11137851, DOI: 10.1016/j.jpsychires.2023.03.034.Peer-Reviewed Original ResearchConceptsExcoriation disorderPublic health impactEpidemiological studiesGeneral populationSystematic reviewHealth impactsDifferent prevalence estimatesPooled prevalenceOverall prevalenceInclusion criteriaMale ratioPubMed searchPrevalence estimatesGender distributionDisordersPrevalenceDatabase searchEMBASEReviewPopulationPubMedPsycINFOStudyWomenCharacteristics of trichotillomania and excoriation disorder across the lifespan
Lin A, Farhat L, Flores J, Levine J, Fernandez T, Bloch M, Olfson E. Characteristics of trichotillomania and excoriation disorder across the lifespan. Psychiatry Research 2023, 322: 115120. PMID: 36842397, PMCID: PMC10023474, DOI: 10.1016/j.psychres.2023.115120.Peer-Reviewed Original ResearchConceptsExcoriation disorderClinical characteristicsSkin-picking severityAttention-deficit/hyperactivity disorderCo-occurring conditionsBody-focused repetitive behaviorsObsessive-compulsive disorderSeverity scoreCurrent symptomsSignificant positive correlationTrichotillomaniaHyperactivity disorderDisordersSelf-reported anxietyAge 4High rateSubtypesSelf-report measuresSeverityCross-sectional survey responsesRepetitive behaviorsAdulthoodPositive correlation
2022
Prevalence and gender distribution of trichotillomania: A systematic review and meta-analysis
Thomson HA, Farhat LC, Olfson E, Levine JLS, Bloch MH. Prevalence and gender distribution of trichotillomania: A systematic review and meta-analysis. Journal Of Psychiatric Research 2022, 153: 73-81. PMID: 35802953, DOI: 10.1016/j.jpsychires.2022.06.058.Peer-Reviewed Original ResearchConceptsNoticeable hair lossHair-pulling behaviorOdds ratioHair lossPrevalence estimatesSystematic reviewGender distributionSignificant public health impactMental Disorders criteriaPublic health impactMale odds ratioFemale preponderanceEpidemiological studiesPrevalence dataUnderstudied conditionDisorder criteriaStatistical ManualTrichotillomaniaEpidemiological samplePrevalenceHealth impactsConsiderable heterogeneityDatabase searchAdditional researchFemalesWhole‐exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants
Olfson E, Lebowitz ER, Hommel G, Pashankar N, Silverman WK, Fernandez TV. Whole‐exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants. Depression And Anxiety 2022, 39: 474-484. PMID: 35312124, PMCID: PMC9246845, DOI: 10.1002/da.23251.Peer-Reviewed Original ResearchConceptsWhole-exome DNA sequencingRisk genesDNA sequencingCanonical biological pathwaysMissense genetic variantsNovo variantsGenetic variant detectionParent-child triosGenomic approachesDe novo variantsLikely geneBiologic pathwaysDeleterious variantsBiological pathwaysDamaging variantsGenesGenetic variantsPathwayVariant detectionSequencingNetwork analysisGenetic factorsUnderlying biologyVariantsEnrichment
2020
FROM NEUROSCIENCE TO EVIDENCE-BASED TREATMENTS: AN UPDATE ON BODY-FOCUSED REPETITIVE BEHAVIORS RESEARCH
Olfson E, Bloch M, Raikes J. FROM NEUROSCIENCE TO EVIDENCE-BASED TREATMENTS: AN UPDATE ON BODY-FOCUSED REPETITIVE BEHAVIORS RESEARCH. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: s327. DOI: 10.1016/j.jaac.2020.07.782.Peer-Reviewed Original ResearchPharmacological and behavioral treatment for trichotillomania: An updated systematic review with meta‐analysis
Farhat LC, Olfson E, Nasir M, Levine JLS, Li F, Miguel EC, Bloch MH. Pharmacological and behavioral treatment for trichotillomania: An updated systematic review with meta‐analysis. Depression And Anxiety 2020, 37: 715-727. PMID: 32390221, DOI: 10.1002/da.23028.Peer-Reviewed Original ResearchConceptsClinical trialsSingle randomized clinical trialTTM symptomsFirst-line medicationRandomized clinical trialsStrong evidence baseLarge treatment effectsHair pulling disorderEffective medicationsAvailable agentsPharmacological agentsAdditional trialsDrug AdministrationPsychiatric conditionsSystematic reviewN-acetylcysteineBehavioral treatmentBehavioral therapyEvidence baseTrichotillomaniaTrialsRelative efficacyTreatment effectsMedicationsSymptoms
2019
Measuring Treatment Response in Pediatric Trichotillomania: A Meta-Analysis of Clinical Trials
Farhat LC, Olfson E, Levine JLS, Li F, Franklin ME, Lee HJ, Lewin AB, McGuire JF, Rahman O, Storch EA, Tolin DF, Zickgraf HF, Bloch MH. Measuring Treatment Response in Pediatric Trichotillomania: A Meta-Analysis of Clinical Trials. Journal Of Child And Adolescent Psychopharmacology 2019, 30: 306-315. PMID: 31794677, PMCID: PMC7476376, DOI: 10.1089/cap.2019.0103.Peer-Reviewed Original ResearchConceptsClinical trialsTreatment responseOptimal cut pointCut pointsMassachusetts General Hospital Hair Pulling ScalePediatric trichotillomaniaClinical Global Impressions-Improvement scoreMeta-DiSc softwareClinical responsePediatric populationAge-related differencesSeverity ScaleImprovement scoresMeta-AnalysisYouden indexStandardized definitionsTTM severityOlder childrenTrichotillomaniaTrialsParent versionNational InstituteYoung childrenMGH-HPSDiscriminative abilityDe Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette’s Disorder and Autism
Cappi C, Oliphant ME, Péter Z, Zai G, Conceição do Rosário M, Sullivan CAW, Gupta AR, Hoffman EJ, Virdee M, Olfson E, Abdallah SB, Willsey AJ, Shavitt RG, Miguel EC, Kennedy JL, Richter MA, Fernandez TV. De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette’s Disorder and Autism. Biological Psychiatry 2019, 87: 1035-1044. PMID: 31771860, PMCID: PMC7160031, DOI: 10.1016/j.biopsych.2019.09.029.Peer-Reviewed Original ResearchPEDIATRIC TRICHOTILLOMANIA: AN UPDATE ON SCREENING, GENETICS, AND TREATMENT
Bloch M, Olfson E, Stewart S. PEDIATRIC TRICHOTILLOMANIA: AN UPDATE ON SCREENING, GENETICS, AND TREATMENT. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 58: s313-s314. DOI: 10.1016/j.jaac.2019.07.722.Peer-Reviewed Original Research10.1 GENETIC FINDINGS IN TRICHOTILLOMANIA
Olfson E. 10.1 GENETIC FINDINGS IN TRICHOTILLOMANIA. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 58: s314. DOI: 10.1016/j.jaac.2019.07.723.Peer-Reviewed Original Research
2018
Identifying standardized definitions of treatment response in trichotillomania: A meta-analysis
Farhat LC, Olfson E, Li F, Telang S, Bloch MH. Identifying standardized definitions of treatment response in trichotillomania: A meta-analysis. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2018, 89: 446-455. PMID: 30336171, DOI: 10.1016/j.pnpbp.2018.10.009.Peer-Reviewed Original ResearchConceptsTreatment responseClinical trialsMassachusetts General Hospital Hair Pulling ScaleClinical Global Impression-Improvement scale scoreMGH-HPSImprovement Scale scoresMeta-DiSc softwarePediatric subjectsSeverity ScaleScale scoreAdult subjectsSymptom severityYouden indexStandardized definitionsTrialsNational InstituteCentral databaseTrichotillomaniaPercent reductionUniversal definitionAdequate dataSubjectsResponsePubMedPediatric Trichotillomania
Olfson E, Bloch M, Piacentini J. Pediatric Trichotillomania. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: s320. DOI: 10.1016/j.jaac.2018.07.805.Peer-Reviewed Original Research33.2 A Genomic Approach to Pediatric Trichotillomania
Olfson E. 33.2 A Genomic Approach to Pediatric Trichotillomania. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: s321. DOI: 10.1016/j.jaac.2018.07.807.Peer-Reviewed Original Research
2017
Genes Orchestrating Brain Function
Olfson E, Ross DA. Genes Orchestrating Brain Function. Biological Psychiatry 2017, 82: e17-e19. PMID: 28693738, PMCID: PMC5712901, DOI: 10.1016/j.biopsych.2017.06.003.Peer-Reviewed Original Research