2024
Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes
Olfson E, Farhat L, Liu W, Vitulano L, Zai G, Lima M, Parent J, Polanczyk G, Cappi C, Kennedy J, Fernandez T. Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. Nature Communications 2024, 15: 5870. PMID: 38997333, PMCID: PMC11245598, DOI: 10.1038/s41467-024-50247-7.Peer-Reviewed Original ResearchConceptsDNA sequencesRisk genesHigh-confidence risk genesWhole-exome DNA sequencingSequencing of familiesIdentified de novoLysine demethylase 5BDNA variantsTrio cohortBiological pathwaysGenesSequencing cohortGenetic factorsChildhood neurodevelopmental disordersAttention-deficit/hyperactivity disorderSequenceVariantsADHD riskNeurodevelopmental disordersKDM5BDNAMutationsFamilyLysineDiscovery
2016
Implications of Personal Genomic Testing for Health Behaviors: The Case of Smoking
Olfson E, Hartz S, Carere DA, Green RC, Roberts JS, Bierut LJ, Group F. Implications of Personal Genomic Testing for Health Behaviors: The Case of Smoking. Nicotine & Tobacco Research 2016, 18: 2273-2277. PMID: 27613923, PMCID: PMC5103936, DOI: 10.1093/ntr/ntw168.Peer-Reviewed Original ResearchConceptsCurrent smokersSmoking-related diseasesPersonal genomic testingGenetic risk resultsFormer smokersGenomic testingLung cancerConsumer genomic testingGenetic riskSmoking behaviorHealth behaviorsFalse reassuranceUnhealthy behaviorsBaseline current smokersSame smoking statusConsumer personal genomic testingSmoking-related illnessesHigher quit ratesGenomic test resultsCase of smokingBehavior 6 monthsSmoking statusHeart diseaseQuit ratesGenomic testing results
2014
An ADH1B Variant and Peer Drinking in Progression to Adolescent Drinking Milestones: Evidence of a Gene‐by‐Environment Interaction
Olfson E, Edenberg HJ, Nurnberger J, Agrawal A, Bucholz KK, Almasy LA, Chorlian D, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Porjesz B, Schuckit MA, Tischfield JA, Wang J, Wetherill L, Foroud TM, Rice J, Goate A, Bierut LJ. An ADH1B Variant and Peer Drinking in Progression to Adolescent Drinking Milestones: Evidence of a Gene‐by‐Environment Interaction. Alcohol Clinical And Experimental Research 2014, 38: 2541-2549. PMID: 25257461, PMCID: PMC4256939, DOI: 10.1111/acer.12524.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlcohol DehydrogenaseAlcohol DrinkingAlcoholismAlcohol-Related DisordersAllelesChildDisease ProgressionDrinking BehaviorFemaleGene-Environment InteractionGenetic VariationHumansLongitudinal StudiesMalePeer GroupProportional Hazards ModelsPsychological DistanceRisk FactorsSocial EnvironmentUnited StatesYoung AdultConceptsProtective effectDSM-5 symptomsFirst intoxicationImportant public health concernProportional hazards regressionAlcohol use disorder symptomsADH1B variantsDrinking milestonesAlcohol use disorderDrinking behaviorPublic health concernDiverse adult populationsAlcohol dehydrogenase 1BFinal modelPrimary outcomeHazards regressionAfrican American individualsRisk factorsUse disordersAdult populationAge 18SymptomsHealth concernIntoxicationDisorder symptomsReturn of individual genetic results in a high-risk sample: enthusiasm and positive behavioral change
Hartz SM, Olfson E, Culverhouse R, Cavazos-Rehg P, Chen LS, DuBois J, Fisher S, Kaphingst K, Kaufman D, Plunk A, Ramnarine S, Solomon S, Saccone NL, Bierut LJ. Return of individual genetic results in a high-risk sample: enthusiasm and positive behavioral change. Genetics In Medicine 2014, 17: 374-379. PMID: 25166427, PMCID: PMC4344933, DOI: 10.1038/gim.2014.110.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyDepressionFollow-Up StudiesGenetic TestingHumansPublic Health SurveillanceRisk FactorsTruth DisclosureConceptsHigh riskPathway GenomicsBaseline measuresAdequate health literacyMultiple risk factorsSymptoms of depressionPercent of participantsHigh baseline measuresAdverse psychological reactionsIncreased riskRisk factorsHigh-risk sampleCessation attemptsGenetic resultsHealth literacyNicotine dependenceUnderserved populationsPositive behavioral changesGenetic riskHealth insuranceDepressionAfrican AmericansLower ratesRiskBehavioral changes