2014
Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
Annibali D, Whitfield J, Favuzzi E, Jauset T, Serrano E, Cuartas I, Redondo-Campos S, Folch G, Gonzàlez-Juncà A, Sodir N, Massó-Vallés D, Beaulieu M, Swigart L, Mc Gee M, Somma M, Nasi S, Seoane J, Evan G, Soucek L. Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis. Nature Communications 2014, 5: 4632. PMID: 25130259, PMCID: PMC4143920, DOI: 10.1038/ncomms5632.Peer-Reviewed Original ResearchConceptsMYC inhibitionElevated MYC levelsPatient-derived tumorsAdult central nervous systemHuman glioblastoma cell linesCentral nervous systemFormation of multinucleated cellsPrimary tumorGlioblastoma cell linesStandard therapyOrthotopic xenograftsMYC levelsMouse modelIncreased apoptosisCancer therapyHuman tumorsMitotic catastropheTherapeutic strategiesHuman gliomasMYCTumorNervous systemInvasive astrocytomasGliomaCell lines
2013
Abstract 1085: MYC inhibition is a potent therapy against glioma and induces mitotic crisis in cancer cells.
Annibali D, Whitfield J, Favuzzi E, Jauset T, serrano E, Folch G, Cuartas M, Gonzalez A, Brown Swigart L, Nasi S, Evan G, Seoane J, Soucek L. Abstract 1085: MYC inhibition is a potent therapy against glioma and induces mitotic crisis in cancer cells. Cancer Research 2013, 73: 1085-1085. DOI: 10.1158/1538-7445.am2013-1085.Peer-Reviewed Original ResearchMYC inhibitionGrade IV glioblastomaCentral nervous systemTherapeutic strategiesCancer cellsTherapeutic impactRegression of tumorsSignificant survival advantageAmerican Association for Cancer ResearchMitotic crisisPatient-derived tumor samplesOrigin of gliomasCells of origin of gliomasAdult human central nervous systemHuman glioblastoma cell linesMedian survivalPrimary tumorHuman central nervous systemGlioblastoma cell linesStandard therapyLung tumorsOrthotopic xenograftsTumor cellsSurvival advantageTumor samples