2010
Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA–regulated apical chloride channels in cortical collecting duct
Lu M, Dong K, Egan ME, Giebisch GH, Boulpaep EL, Hebert SC. Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA–regulated apical chloride channels in cortical collecting duct. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 6082-6087. PMID: 20231442, PMCID: PMC2851921, DOI: 10.1073/pnas.0902661107.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoatesChloride ChannelsCyclic AMPCyclic AMP-Dependent Protein KinasesCystic Fibrosis Transmembrane Conductance RegulatorFemaleIn Vitro TechniquesKidney CortexKidney Tubules, CollectingKineticsMiceMice, Inbred C57BLMice, Inbred CFTRMice, KnockoutMice, TransgenicMutationOocytesPatch-Clamp TechniquesPotassium Channels, Inwardly RectifyingRecombinant ProteinsThiazolidinesXenopus laevisConceptsCystic fibrosis transmembrane conductance regulatorFibrosis transmembrane conductance regulatorTransmembrane conductance regulatorCl- channel activityConductance regulatorCl- channelsApical membrane proteinsExpression of CFTRChannel activityCFTR Cl- channelApical chloride channelApical cell membraneDeltaF508 CFTR mutationMembrane proteinsCatalytic subunitXenopus laevis oocytesForm proteinPrincipal cellsCFTR channelsROMK null miceApical patchesApical membraneSingle-channel conductanceChloride channelsCell membrane
2000
Regulation of volume‐activated chloride channels by P‐glycoprotein: phosphorylation has the final say!
Idriss H, Hannun Y, Boulpaep E, Basavappa S. Regulation of volume‐activated chloride channels by P‐glycoprotein: phosphorylation has the final say! The Journal Of Physiology 2000, 524: 629-636. PMID: 10790147, PMCID: PMC2269906, DOI: 10.1111/j.1469-7793.2000.00629.x.Peer-Reviewed Original ResearchConceptsProtein kinase CReversible phosphorylationChloride channelsChloride channel activityPhosphorylation of PgpSuch phosphorylationMultiple phosphorylationVolume-activated chloride channelsTransmembrane transportersKinase CPhosphorylationInhibition of transportCell volume changesPossible regulationChannel activityP-glycoproteinPotential involvementSuch regulationRegulation functionRegulationUnrelated drugsPgpProteinTransportersOverexpression
1998
Transcellular Chloride Pathways in Ambystoma Proximal Tubule
Abdulnour-Nakhoul S, Boulpaep E. Transcellular Chloride Pathways in Ambystoma Proximal Tubule. The Journal Of Membrane Biology 1998, 166: 15-35. PMID: 9784583, DOI: 10.1007/s002329900444.Peer-Reviewed Original ResearchMeSH KeywordsAmbystomaAnimalsCell MembraneChloride ChannelsChloridesIon TransportMembrane PotentialsSodiumConceptsProximal tubulesChloride channel blockerContribution of transportersAmbystoma proximal tubuleTransepithelial potential differenceDisulfonic stilbeneCl-HCO3 exchangeFree RingerLines of evidenceTubulesBasolateral cell membraneLumenNa-independent ClMembrane potentialBasolateral membraneApical membrane potentialAiClBlockers