1987
Aldosterone increases the maximal turnover rate of the sodium pump
Halevy J, Boulpaep E, Binder H, Hayslett J. Aldosterone increases the maximal turnover rate of the sodium pump. Pflügers Archiv - European Journal Of Physiology 1987, 410: 476-480. PMID: 3432052, DOI: 10.1007/bf00586528.Peer-Reviewed Original ResearchConceptsSodium pumpSodium transportLow sodium dietEffects of aldosteroneAdministration of aldosteroneHigher plasma levelsIntact adrenal glandsRat distal colonEquivalent short-circuit currentAddition of nystatinH aldosteroneSodium dietAdrenal glandChronic conditionsPlasma levelsDistal colonAcute actionsAldosteroneUssing chambersHours of exposureChronic exposureSame time periodApical barrierSimilar changesMucosal solution
1984
Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule
Hirsch D, Kashgarian M, Boulpaep E, Hayslett J. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule. Kidney International 1984, 26: 798-807. PMID: 6099857, DOI: 10.1038/ki.1984.221.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCollecting tubuleDistal convolutionAldosterone levelsPotassium adaptationChronic potassium loadingMineralocorticoid-sensitive tissuesRole of aldosteronePlasma aldosterone levelsAction of aldosteroneIntact adrenal glandsPotassium loadingPhysiological plasma levelsChronic hyperaldosteronismTransepithelial potential differenceChronic administrationEpithelial changesAdrenal glandPlasma levelsDietary potassium loadingBasal valuesAldosteroneTubule cellsNephron segmentsTarget tissues