Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon
Joiner WJ, Basavappa S, Vidyasagar S, Nehrke K, Krishnan S, Binder HJ, Boulpaep EL, Rajendran VM. Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon. AJP Gastrointestinal And Liver Physiology 2003, 285: g185-g196. PMID: 12606302, DOI: 10.1152/ajpgi.00337.2002.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApaminCarbacholChloridesCHO CellsCholinergic AgonistsClotrimazoleColonCricetinaeGene ExpressionGrowth InhibitorsIntermediate-Conductance Calcium-Activated Potassium ChannelsMaleMembrane PotentialsMolecular Sequence DataPatch-Clamp TechniquesPeptidesPotassiumPotassium ChannelsPotassium Channels, Calcium-ActivatedPotassium, DietaryRatsRats, Sprague-DawleyRubidium RadioisotopesConceptsChannel inhibitors clotrimazoleRat proximal colonProximal colonSK channel inhibitorsAddition of thapsigarginExpression of Ca2Muscarinic receptorsCholinergic agentsMuscarinic agonistsEpithelial stripsIKCa channelsMucosal additionSerosal surfaceColonic epitheliumIK channelsIntracellular Ca2Channel inhibitorsRSK4 mRNAColonWestern blottingIK proteinSecretionColonic cryptsPrecise mechanismConfocal immunofluorescence