Genomic structure, promoter characterisation and mutational analysis of the S100A7 gene: exclusion of a candidate for familial psoriasis susceptibility
Semprini S, Capon F, Bovolenta S, Bruscia E, Pizzuti A, Fabrizi G, Schietroma C, Zambruno G, Dallapiccola B, Novelli G. Genomic structure, promoter characterisation and mutational analysis of the S100A7 gene: exclusion of a candidate for familial psoriasis susceptibility. Human Genetics 1999, 104: 130-134. PMID: 10190323, DOI: 10.1007/s004390050925.Peer-Reviewed Original ResearchConceptsGenomic structureComplex gene clustersSp1-binding motifTranscription start siteStrong promoter activityPsoriasis susceptibilityΒ-galactosidase geneExon-intron boundariesGene clusterStart siteTATA boxGene promoterNucleotide variationsSingle-strand conformation polymorphismMutational analysisPromoter activityPromoter regionChromosome 1q21Sequencing techniquesS100A7 geneFunctional assaysGenesSets of primersDirect sequencing techniquePreferential association