2024
Contemporary Training in American Critical Care Cardiology: Minnesota Critical Care Cardiology Education Summit JACC Scientific Expert Panel
Elliott A, Bartos J, Barnett C, Miller P, Roswell R, Alviar C, Bennett C, Berg D, Bohula E, Chonde M, Dahiya G, Fleitman J, Gage A, Hansra B, Higgins A, Hollenberg S, Horowitz J, Jentzer J, Katz J, Karpenshif Y, Lee R, Menon V, Metkus T, Mukundan S, Rhinehart Z, Senman B, Senussi M, Solomon M, Vallabhajosyula S, Dudzinski D. Contemporary Training in American Critical Care Cardiology: Minnesota Critical Care Cardiology Education Summit JACC Scientific Expert Panel. Journal Of The American College Of Cardiology 2024, 84: 1436-1454. PMID: 39357941, DOI: 10.1016/j.jacc.2024.05.082.Peer-Reviewed Original ResearchComplex Heart–Lung Ventilator Emergencies in the CICU
Lopez M, Applefeld W, Miller P, Elliott A, Bennett C, Lee B, Barnett C, Solomon M, Corradi F, Sionis A, Mireles-Cabodevila E, Tavazzi G, Alviar C. Complex Heart–Lung Ventilator Emergencies in the CICU. Cardiology Clinics 2024, 42: 253-271. PMID: 38631793, DOI: 10.1016/j.ccl.2024.02.010.Peer-Reviewed Original ResearchPropofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction
Thomas A, Banna S, Shahu A, Ali T, Schenck C, Patel B, Notarianni A, Phommalinh M, Kochar A, Heck C, van Diepen S, Miller P. Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction. American Heart Journal 2024, 272: 116-125. PMID: 38554762, DOI: 10.1016/j.ahj.2024.03.013.Peer-Reviewed Original ResearchConceptsAssociated with lower mortalityAcute myocardial infarctionInvasive mechanical ventilationLower mortalityUS national databaseClinical Data BaseMyocardial infarctionIll patient populationLength of stayCritically ill patient populationIn-hospital mortalityInverse probability treatmentOptimal induction agentInduction agentNational databaseClinical outcomesMechanical ventilationProbability treatmentPropensity weightingPatient populationRandomized trialsMortalityUtilization of propofolVentilator daysPropofol groupTransatlantic collaboration detailing research priorities in critical care cardiology
Miller P. Transatlantic collaboration detailing research priorities in critical care cardiology. European Heart Journal Acute Cardiovascular Care 2024, 13: 261-261. PMID: 38234272, DOI: 10.1093/ehjacc/zuae009.Peer-Reviewed Original Research
2023
Research Priorities in Critical Care Cardiology JACC Expert Panel
Miller P, Huber K, Bohula E, Krychtiuk K, Pöss J, Roswell R, Tavazzi G, Solomon M, Kristensen S, Morrow D, Care A. Research Priorities in Critical Care Cardiology JACC Expert Panel. Journal Of The American College Of Cardiology 2023, 82: 2329-2337. PMID: 38057075, PMCID: PMC10752230, DOI: 10.1016/j.jacc.2023.09.828.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitCritical care cardiologyHigh-quality evidencePatient populationIntensive care unitCritical care researchCare unitIll patientsSociety guidelinesClinical trialsPractice patternsCare researchExpert panelDiagnosisResearch prioritiesComorbiditiesPatientsPopulationLimited guidanceCliniciansCardiologyTrialsCarePrognostic significance of haemodynamic parameters in patients with cardiogenic shock
Berg D, Kaur G, Bohula E, Baird-Zars V, Alviar C, Barnett C, Barsness G, Burke J, Chaudhry S, Chonde M, Cooper H, Daniels L, Dodson M, Gerber D, Ghafghazi S, Gidwani U, Goldfarb M, Guo J, Hillerson D, Kenigsberg B, Kochar A, Kontos M, Kwon Y, Lopes M, Loriaux D, Miller P, O’Brien C, Papolos A, Patel S, Pisani B, Potter B, Prasad R, Roswell R, Shah K, Sinha S, Smith T, Solomon M, Teuteberg J, Thompson A, Zakaria S, Katz J, van Diepen S, Morrow D. Prognostic significance of haemodynamic parameters in patients with cardiogenic shock. European Heart Journal Acute Cardiovascular Care 2023, 12: 651-660. PMID: 37640029, PMCID: PMC10599641, DOI: 10.1093/ehjacc/zuad095.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitInvasive haemodynamic assessmentRight atrial pressureCardiogenic shockHaemodynamic parametersHaemodynamic assessmentCICU admissionSerum lactateCritical Care Cardiology Trials NetworkLower pulmonary artery pulsatility indexPulmonary capillary wedge pressure ratioLow systemic vascular resistancePulmonary artery pulsatility indexLower systolic blood pressureTemporary mechanical circulatory supportMedian cardiac indexTIMI Study GroupVasoactive-inotropic scoreArtery pulsatility indexEnd-organ dysfunctionRight ventricular dysfunctionSystemic vascular resistancePulmonary artery catheterSystolic blood pressureManagement of patientsPulmonary Artery Catheter Use and Mortality in the Cardiac Intensive Care Unit
Kadosh B, Berg D, Bohula E, Park J, Baird-Zars V, Alviar C, Alzate J, Barnett C, Barsness G, Burke J, Chaudhry S, Daniels L, DeFilippis A, Delicce A, Fordyce C, Ghafghazi S, Gidwani U, Goldfarb M, Katz J, Keeley E, Kenigsberg B, Kontos M, Lawler P, Leibner E, Menon V, Metkus T, Miller P, O'Brien C, Papolos A, Prasad R, Shah K, Sinha S, Snell R, So D, Solomon M, Ternus B, Teuteberg J, Toole J, van Diepen S, Morrow D, Roswell R. Pulmonary Artery Catheter Use and Mortality in the Cardiac Intensive Care Unit. JACC Heart Failure 2023, 11: 903-914. PMID: 37318422, PMCID: PMC10527413, DOI: 10.1016/j.jchf.2023.04.007.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitPulmonary artery catheterUse of PACHospital mortalityCare unitPAC useCardiac patientsCritical Care Cardiology Trials NetworkPulmonary artery catheter usePatient-level factorsIll cardiac patientsIntensive care unitMechanical circulatory supportCardiac critical careAppropriate useCardiogenic etiologyAdmission diagnosisShock patientsCatheter useArtery catheterCICU admissionHeart failureRandomized trialsCirculatory supportCritical careThe Time Is Now to Investigate Ventilator Settings in Acute Cardiovascular Patients ∗
Miller P, Abrams D. The Time Is Now to Investigate Ventilator Settings in Acute Cardiovascular Patients ∗. JACC Heart Failure 2023, 11: 969-971. PMID: 37204364, PMCID: PMC10191154, DOI: 10.1016/j.jchf.2023.04.005.Commentaries, Editorials and LettersRocuronium Versus Succinylcholine in Patients With Acute Myocardial Infarction Requiring Mechanical Ventilation
Schenck C, Banna S, Heck C, Ali T, Miller P. Rocuronium Versus Succinylcholine in Patients With Acute Myocardial Infarction Requiring Mechanical Ventilation. Journal Of The American Heart Association 2023, 12: e8468. PMID: 37158165, PMCID: PMC10227322, DOI: 10.1161/jaha.123.029775.Peer-Reviewed Original ResearchExposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock
Jentzer J, Miller P, Alviar C, Yalamuri S, Bohman J, Tonna J. Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock. Circulation Heart Failure 2023, 16: e010328. PMID: 36871240, PMCID: PMC10121893, DOI: 10.1161/circheartfailure.122.010328.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenator supportMembrane oxygenator supportHospital mortalityCardiogenic shockVenoarterial ECMOSevere hyperoxiaMild hyperoxiaHigher PaO2Extracorporeal Life Support Organization registryHigher arterial partial pressureHours of ECMOVenoarterial ECMO supportMultivariable logistic regressionArterial partial pressureClinical trial dataAcid-base statusArterial hyperoxiaExtracorporeal CPRRegistry patientsECMO supportAirway pressureNormal PaO2Ventilatory statusClinical variablesCS patients
2022
Characteristics, therapies, and outcomes of In-Hospital vs Out-of-Hospital cardiac arrest in patients presenting to cardiac intensive care units: From the critical care Cardiology trials network (CCCTN)
Carnicelli A, Keane R, Brown K, Loriaux D, Kendsersky P, Alviar C, Arps K, Berg D, Bohula E, Burke J, Dixson J, Gerber D, Goldfarb M, Granger C, Guo J, Harrison R, Kontos M, Lawler P, Miller P, Nativi-Nicolau J, Newby L, Racharla L, Roswell R, Shah K, Sinha S, Solomon M, Teuteberg J, Wong G, van Diepen S, Katz J, Morrow D. Characteristics, therapies, and outcomes of In-Hospital vs Out-of-Hospital cardiac arrest in patients presenting to cardiac intensive care units: From the critical care Cardiology trials network (CCCTN). Resuscitation 2022, 183: 109664. PMID: 36521683, PMCID: PMC9899313, DOI: 10.1016/j.resuscitation.2022.12.002.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitCritical Care Cardiology Trials NetworkOutcome of admissionIntensive care unitCardiac arrestCare unitContemporary cardiac intensive care unitsTertiary cardiac intensive care unitsTrials NetworkLower lactateLower crude mortalityRenal replacement therapyMechanical circulatory supportHospital cardiac arrestHospital mortalityIHCA patientsInvasive hemodynamicsCICU admissionIn-HospitalCoronary diseaseCrude mortalityHeart failureOHCA patientsAtrial fibrillationCirculatory supportClinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock
Miller PE, Bromfield SG, Ma Q, Crawford G, Whitney J, DeVries A, Desai NR. Clinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA Internal Medicine 2022, 182: 926-933. PMID: 35849410, PMCID: PMC9295019, DOI: 10.1001/jamainternmed.2022.2735.Peer-Reviewed Original ResearchConceptsIntra-aortic balloon pumpPercutaneous coronary interventionKidney replacement therapyAcute myocardial infarctionCardiogenic shockClinical outcomesLVAD useVentricular assist deviceBalloon pumpRetrospective propensity-matched cohort studyAssist deviceAcute Myocardial Infarction ComplicatedPropensity-matched cohort studyTotal health care costsMyocardial Infarction ComplicatedPropensity-matched analysisPropensity-matched pairsLong-term outcomesRisk of mortalityAdministrative claims dataHealth care costsIABP useIndex admissionCohort studyCoronary interventionPatients With Acute Coronary Syndromes Admitted to Contemporary Cardiac Intensive Care Units: Insights From the CCCTN Registry
Fagundes A, Berg DD, Park JG, Baird-Zars VM, Newby LK, Barsness GW, Miller PE, van Diepen S, Katz JN, Phreaner N, Roswell RO, Menon V, Daniels LB, Morrow DA, Bohula EA, Investigators F. Patients With Acute Coronary Syndromes Admitted to Contemporary Cardiac Intensive Care Units: Insights From the CCCTN Registry. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008652. PMID: 35862019, DOI: 10.1161/circoutcomes.121.008652.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitAcute coronary syndromeContemporary cardiac intensive care unitsIntensive care unitCICU admissionAdmission indicationsCICU mortalityCoronary syndromeCare unitPrimary diagnosisIntensive care unit therapyEpidemiology of patientsNon-ACS diagnosisLow-risk patientsTime of admissionCICU lengthAcute severityVasoactive therapyPatient characteristicsRespiratory insufficiencyRisk patientsCommon indicationRoutine admissionACS admissionsProspective studyStaffing models in the cardiac intensive care unit
Quien M, Thomas A, Ludmir J, Miller PE. Staffing models in the cardiac intensive care unit. Current Opinion In Critical Care 2022, 28: 453-459. PMID: 35757936, DOI: 10.1097/mcc.0000000000000958.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac intensive care unitIntensive care unitCare unitContemporary cardiac intensive care unitsModern cardiac intensive care unitMechanical circulatory supportSick patient populationFuture multicenter studiesStaffing modelsPreponderance of dataShock teamRespiratory failureIll patientsCirculatory supportMulticenter studyCardiac arrestPatient populationCardiac intensivistsIll populationMortalityRecent evidenceIntensivistsPatientsRecent dataPopulationRelation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome
Biondi M, Jain S, Fuery M, Thomas A, Ali T, Alviar CL, Desai NR, Miller PE. Relation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome. The American Journal Of Cardiology 2022, 176: 24-29. PMID: 35606175, DOI: 10.1016/j.amjcard.2022.04.034.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseVentilator-free daysHeart diseaseHistory of IHDImpact of IHDAcute respiratory distress syndromePredictors of mortalityRespiratory distress syndromeSeverity of illnessMultivariable logistic regressionMultivariable adjustmentSecondary outcomesDistress syndromeOrgan failurePrimary outcomeClinical outcomesIll subgroupStudy criteriaTreatment paradigmClinical trialsARDS severityPatientsHigh mortalityEnd pointMortality
2021
Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes
Miller PE, Mullan CW, Chouairi F, Sen S, Clark KA, Reinhardt S, Fuery M, Anwer M, Geirsson A, Formica R, Rogers JG, Desai NR, Ahmad T. Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes. European Heart Journal Acute Cardiovascular Care 2021, 10: 843-851. PMID: 34389855, PMCID: PMC8557439, DOI: 10.1093/ehjacc/zuab063.Peer-Reviewed Original ResearchConceptsHeart transplantationMechanical ventilationSingle-organ heart transplantationMedian waitlist timeOrgan Sharing databaseTime of transplantationMultivariable logistic regressionMultivariable adjustmentWaitlist timeClinical outcomesSharing databasePoor outcomeVentilated patientsUnited NetworkTemporary mechanical supportClinical acuityTransplantationPatientsPrevious dialysisLogistic regressionMortalityStrong associationReasonable outcomesOutcomesAssociationThe association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality
Nandiwada S, Islam S, Jentzer JC, Miller PE, Fordyce CB, Lawler P, Alviar CL, Sun LY, Dover DC, Lopes RD, Kaul P, van Diepen S. The association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality. European Heart Journal Acute Cardiovascular Care 2021, 10: 797-805. PMID: 34318875, PMCID: PMC9067446, DOI: 10.1093/ehjacc/zuab055.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitMechanical ventilationHospital mortalityRespiratory failureCICU LOSNon-invasive mechanical ventilationNational population-based dataInvasive mechanical ventilationVolume-mortality relationshipProlonged mechanical ventilationProportion of patientsHigh-volume hospitalsPercutaneous coronary interventionLow-volume centersHigh-volume centersIntensive care unitPopulation-based dataOutcomes of interestCICU lengthCICU admissionCoronary interventionSurgical ICUCare unitVolume centersLower incidenceAssociation between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials
Miller PE, Van Diepen S, Metkus TS, Alviar CL, Rayner-Hartley E, Rathwell S, Katz JN, Ezekowitz J, Desai NR, Ahmad T. Association between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials. Journal Of Cardiac Failure 2021, 27: 602-606. PMID: 33556546, PMCID: PMC8527461, DOI: 10.1016/j.cardfail.2021.01.018.Peer-Reviewed Original ResearchConceptsAcute heart failureBaseline ejection fractionMechanical ventilationRespiratory failureHeart failureClinical trialsClinical outcomesHF etiologyHF rehospitalizationEjection fractionAcute HF admissionBaseline diabetes mellitusHF clinical trialsMechanical ventilation groupMechanical ventilation useProportion of patientsChronic lung diseaseMultivariable logistic regressionOriginal clinical trialsCause mortalityHF admissionsIndex hospitalizationMultivariable adjustmentSmoking historyVentilation groupTransition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes
Miller PE, Chouairi F, Thomas A, Kunitomo Y, Aslam F, Canavan ME, Murphy C, Daggula K, Metkus T, Vallabhajosyula S, Carnicelli A, Katz JN, Desai NR, Ahmad T, Velazquez EJ, Brennan J. Transition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes. Journal Of The American Heart Association 2021, 10: e018182. PMID: 33412899, PMCID: PMC7955420, DOI: 10.1161/jaha.120.018182.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitIntensive care unitHospital mortalityCare unitCICU mortalityClinical outcomesModern cardiac intensive care unitSurgical intensive care unitTotal hospital chargesSeverity of illnessMultivariable logistic regressionCICU lengthMultivariable adjustmentRespiratory insufficiencyPrimary outcomeUnique admissionsHospital chargesCardiac arrestSubgroup analysisImproved outcomesMortalityLogistic regressionAdmissionClosed unitStaffing models
2020
Prevalence of Noncardiac Multimorbidity in Patients Admitted to Two Cardiac Intensive Care Units and Their Association with Mortality
Miller PE, Thomas A, Breen TJ, Chouairi F, Kunitomo Y, Aslam F, Damluji AA, Anavekar NS, Murphy JG, van Diepen S, Barsness GW, Brennan J, Jentzer J. Prevalence of Noncardiac Multimorbidity in Patients Admitted to Two Cardiac Intensive Care Units and Their Association with Mortality. The American Journal Of Medicine 2020, 134: 653-661.e5. PMID: 33129785, PMCID: PMC8079541, DOI: 10.1016/j.amjmed.2020.09.035.Peer-Reviewed Original ResearchConceptsCritical care therapiesNoncardiac comorbiditiesCICU populationCare therapyLong-term adverse clinical outcomesCardiac intensive care unitIntensive care unit practiceBetter care pathwaysIncreased hospital mortalityNoncardiac organ failureUnique patient admissionsAdverse clinical outcomesIntensive care unitMultivariable logistic regressionLength of stayAcute cardiac illnessCICU patientsHospital mortalityNoncardiac indicationsICU admissionMultivariable adjustmentOrgan failureCare unitClinical outcomesCardiac illness