2023
High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways
Mendes H, Neelakantan U, Liu Y, Fitzpatrick S, Chen T, Wu W, Pruitt A, Jin D, Jamadagni P, Carlson M, Lacadie C, Enriquez K, Li N, Zhao D, Ijaz S, Sakai C, Szi C, Rooney B, Ghosh M, Nwabudike I, Gorodezky A, Chowdhury S, Zaheer M, McLaughlin S, Fernandez J, Wu J, Eilbott J, Vander Wyk B, Rihel J, Papademetris X, Wang Z, Hoffman E. High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports 2023, 42: 112243. PMID: 36933215, PMCID: PMC10277173, DOI: 10.1016/j.celrep.2023.112243.Peer-Reviewed Original ResearchConceptsGene lossFunctional analysisHigh-throughput functional analysisZebrafish mutantsGene discoverySelect mutantsASD genesAutism genesKey pathwaysASD biologyBrain size differencesMutantsGenesSize differencesPathwayGlobal increaseRelevant mechanismsBiologyCentral challengeNeuroimmune dysfunctionRegionFunctionDiscoveryAutism spectrum disorder
2020
Chapter 26 Modeling autism spectrum disorders in zebrafish
Dreosti E, Hoffman E, Rihel J. Chapter 26 Modeling autism spectrum disorders in zebrafish. 2020, 451-480. DOI: 10.1016/b978-0-12-817528-6.00026-7.ChaptersZebrafish modelGenetics of ASDGenome-wide association studiesHundreds of genesNervous system formComplex behavioral repertoireHuman neurodevelopmental disordersWhole-genome sequencingExcellent systemGenetic informationGenome sequencingAssociation studiesGenerate mutationsZebrafishUnique human traitsHuman traitsHuman biologyNeurodevelopmental disordersASD biologyGenetic alterationsRapid discoveryGenesBiologyBehavioral repertoireNeuronal processes